PMID- 32218326
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240328
IS  - 1999-4923 (Print)
IS  - 1999-4923 (Electronic)
IS  - 1999-4923 (Linking)
VI  - 12
IP  - 4
DP  - 2020 Mar 25
TI  - Polymeric Nanocarriers of Drug Delivery Systems in Cancer Therapy.
LID - 10.3390/pharmaceutics12040298 [doi]
LID - 298
AB  - Conventional chemotherapy is the most common therapeutic method for treating 
      cancer by the application of small toxic molecules thatinteract with DNA and 
      causecell death. Unfortunately, these chemotherapeutic agents are non-selective 
      and can damage both cancer and healthy tissues,producing diverse side effects, 
      andthey can have a short circulation half-life and limited targeting. Many 
      synthetic polymers have found application as nanocarriers of intelligent drug 
      delivery systems (DDSs). Their unique physicochemical properties allow them to 
      carry drugs with high efficiency,specificallytarget cancer tissue and control 
      drug release. In recent years, considerable efforts have been made to design 
      smart nanoplatforms, including amphiphilic block copolymers, polymer-drug 
      conjugates and in particular pH- and redox-stimuli-responsive nanoparticles 
      (NPs). This review is focused on a new generation of polymer-based DDSs with 
      specific chemical functionalities that improve their hydrophilicity, drug loading 
      and cellular interactions.Recentlydesigned multifunctional DDSs used in cancer 
      therapy are highlighted in this review.
FAU - Avramovic, Natasa
AU  - Avramovic N
AD  - Institute of Medical Chemistry, Faculty of Medicine, University of Belgrade, 
      11000 Belgrade, Serbia.
FAU - Mandic, Boris
AU  - Mandic B
AD  - Faculty of Chemistry, University of Belgrade, Studentski trg 12-16, 11000 
      Belgrade, Serbia.
FAU - Savic-Radojevic, Ana
AU  - Savic-Radojevic A
AD  - Institute of Medical and Clinical Biochemistry, Faculty of Medicine, University 
      of Belgrade, 11000 Belgrade, Serbia.
FAU - Simic, Tatjana
AU  - Simic T
AD  - Institute of Medical and Clinical Biochemistry, Faculty of Medicine, University 
      of Belgrade, 11000 Belgrade, Serbia.
AD  - Serbian Academy of Sciences and Arts, 11000 Belgrade, Serbia.
LA  - eng
GR  - 172023 and III 46010/Ministarstvo Prosvete, Nauke i Tehnoloskog Razvoja/
PT  - Journal Article
PT  - Review
DEP - 20200325
PL  - Switzerland
TA  - Pharmaceutics
JT  - Pharmaceutics
JID - 101534003
PMC - PMC7238125
OTO - NOTNLM
OT  - block copolymers
OT  - cancer therapy
OT  - polymer-drug conjugates
OT  - polymeric nanocarriers
COIS- The authors declare no con fl ict of interest.
EDAT- 2020/03/29 06:00
MHDA- 2020/03/29 06:01
PMCR- 2020/04/01
CRDT- 2020/03/29 06:00
PHST- 2020/02/15 00:00 [received]
PHST- 2020/03/20 00:00 [revised]
PHST- 2020/03/23 00:00 [accepted]
PHST- 2020/03/29 06:00 [entrez]
PHST- 2020/03/29 06:00 [pubmed]
PHST- 2020/03/29 06:01 [medline]
PHST- 2020/04/01 00:00 [pmc-release]
AID - pharmaceutics12040298 [pii]
AID - pharmaceutics-12-00298 [pii]
AID - 10.3390/pharmaceutics12040298 [doi]
PST - epublish
SO  - Pharmaceutics. 2020 Mar 25;12(4):298. doi: 10.3390/pharmaceutics12040298.