PMID- 32218955
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200928
IS  - 2054-5703 (Print)
IS  - 2054-5703 (Electronic)
IS  - 2054-5703 (Linking)
VI  - 7
IP  - 1
DP  - 2020 Jan
TI  - 3',4'-Dihydro-2'H-spiro[indoline-3,1'-isoquinolin]-2-ones as potential 
      anti-cancer agents: synthesis and preliminary screening.
PG  - 191316
LID - 10.1098/rsos.191316 [doi]
LID - 191316
AB  - Both tetrahydroisoquinolines (THIQs) and oxindoles (OXs) display a broad range of 
      biological activities including anti-cancer activity, and are therefore 
      recognized as two privileged scaffolds in drug discovery. In the present study, 
      24 3',4'-dihydro-2'H-spiro[indoline-3,1'-isoquinolin]-2-ones, designed as 
      molecular hybrids of THIQ and OX, were synthesized and screened in vitro against 
      59 cell lines in the NCI-60 screen. Twenty compounds displayed weak to moderate 
      inhibition of cell proliferation; among them, three compounds displayed at least 
      50% inhibition of cell proliferation. The compounds appeared to target primarily 
      renal cell cancer lines; however, leukaemia, melanoma, non-small cell lung 
      cancer, prostate, ovarian and even breast cancer cell lines were also affected. 
      Therefore, this class of spirooxindoles may provide useful leads in the search 
      for new anti-cancer agents.
CI  - (c) 2020 The Authors.
FAU - Lobe, Maloba M M
AU  - Lobe MMM
AD  - Department of Chemistry, University of Buea, PO Box 63, Buea, Cameroon.
FAU - Efange, Simon M N
AU  - Efange SMN
AD  - Department of Chemistry, University of Buea, PO Box 63, Buea, Cameroon.
LA  - eng
SI  - figshare/10.6084/m9.figshare.c.4776365
PT  - Journal Article
DEP - 20200108
PL  - England
TA  - R Soc Open Sci
JT  - Royal Society open science
JID - 101647528
PMC - PMC7029914
OTO - NOTNLM
OT  - cancer
OT  - molecular hybridization
OT  - spirooxindoles
OT  - tetrahydroisoquinolines
COIS- We declare we have no competing interests.
EDAT- 2020/03/29 06:00
MHDA- 2020/03/29 06:01
PMCR- 2020/01/08
CRDT- 2020/03/29 06:00
PHST- 2019/07/29 00:00 [received]
PHST- 2019/11/19 00:00 [accepted]
PHST- 2020/03/29 06:00 [entrez]
PHST- 2020/03/29 06:00 [pubmed]
PHST- 2020/03/29 06:01 [medline]
PHST- 2020/01/08 00:00 [pmc-release]
AID - rsos191316 [pii]
AID - 10.1098/rsos.191316 [doi]
PST - epublish
SO  - R Soc Open Sci. 2020 Jan 8;7(1):191316. doi: 10.1098/rsos.191316. eCollection 
      2020 Jan.