PMID- 32222633 OWN - NLM STAT- MEDLINE DCOM- 20201120 LR - 20230329 IS - 1096-0953 (Electronic) IS - 0013-9351 (Print) IS - 0013-9351 (Linking) VI - 185 DP - 2020 Jun TI - Maternal serum perfluoroalkyl substance mixtures and thyroid hormone concentrations in maternal and cord sera: The HOME Study. PG - 109395 LID - S0013-9351(20)30288-7 [pii] LID - 10.1016/j.envres.2020.109395 [doi] AB - BACKGROUND: Per- and polyfluoroalkyl substances (PFAS) are ubiquitous. Previous studies have found associations between PFAS and thyroid hormones in maternal and cord sera, but the results are inconsistent. To further address this research question, we used mixture modeling to assess the associations with individual PFAS, interactions among PFAS chemicals, and the overall mixture. METHODS: We collected data through the Health Outcomes and Measures of the Environment (HOME) Study, a prospective cohort study that between 2003 and 2006 enrolled 468 pregnant women and their children in the greater Cincinnati, Ohio region. We assessed the associations of maternal serum PFAS concentrations measured during pregnancy with maternal (n = 185) and cord (n = 256) sera thyroid stimulating hormone (TSH), total thyroxine (TT(4)), total triiodothyronine (TT(3)), free thyroxine (FT(4)), and free triiodothyronine (FT(3)) using two mixture modeling approaches (Bayesian kernel machine regression (BKMR) and quantile g-computation) and multivariable linear regression. Additional models considered thyroid autoantibodies, other non-PFAS chemicals, and iodine deficiency as potential confounders or effect measure modifiers. RESULTS: PFAS, considered individually or as mixtures, were generally not associated with any thyroid hormones. A doubling of perfluorooctanesulfonic acid (PFOS) had a positive association with cord serum TSH in BKMR models but the 95% Credible Interval included the null (beta = 0.09; 95% CrI: -0.08, 0.27). Using BKMR and multivariable models, we found that among children born to mothers with higher thyroid peroxidase antibody (TPOAb), perfluorooctanoic acid (PFOA), PFOS, and perfluorohexanesulfonic acid (PFHxS) were associated with decreased cord FT(4) suggesting modification by maternal TPOAb status. CONCLUSIONS: These findings suggest that maternal serum PFAS concentrations measured in the second trimester of pregnancy are not strongly associated with thyroid hormones in maternal and cord sera. Further analyses using robust mixture models in other cohorts are required to corroborate these findings. CI - Copyright (c) 2020 Elsevier Inc. All rights reserved. FAU - Lebeaux, Rebecca M AU - Lebeaux RM AD - Department of Epidemiology, Geisel School of Medicine at Dartmouth, Lebanon, NH, USA. FAU - Doherty, Brett T AU - Doherty BT AD - Department of Epidemiology, Geisel School of Medicine at Dartmouth, Lebanon, NH, USA. FAU - Gallagher, Lisa G AU - Gallagher LG AD - Independent Researcher, Walpole, MA, USA. FAU - Zoeller, R Thomas AU - Zoeller RT AD - Department of Biology, University of Massachusetts, Amherst, MA, USA. FAU - Hoofnagle, Andrew N AU - Hoofnagle AN AD - Department of Laboratory Medicine, University of Washington, Seattle, WA, USA. FAU - Calafat, Antonia M AU - Calafat AM AD - Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA, USA. FAU - Karagas, Margaret R AU - Karagas MR AD - Department of Epidemiology, Geisel School of Medicine at Dartmouth, Lebanon, NH, USA. FAU - Yolton, Kimberly AU - Yolton K AD - Division of General and Community Pediatrics, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA. FAU - Chen, Aimin AU - Chen A AD - Division of Epidemiology, Department of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, OH, USA. FAU - Lanphear, Bruce P AU - Lanphear BP AD - Child and Family Research Institute, BC Children's and Women's Hospital and Faculty of Health Sciences, Simon Fraser University, Vancouver, British Columbia, Canada. FAU - Braun, Joseph M AU - Braun JM AD - Department of Epidemiology, Brown University School of Public Health, Providence, RI, USA. FAU - Romano, Megan E AU - Romano ME AD - Department of Epidemiology, Geisel School of Medicine at Dartmouth, Lebanon, NH, USA. Electronic address: megan.e.romano@dartmouth.edu. LA - eng GR - T32 AI007519/AI/NIAID NIH HHS/United States GR - P01 ES011261/ES/NIEHS NIH HHS/United States GR - P30 ES006096/ES/NIEHS NIH HHS/United States GR - P01 ES022832/ES/NIEHS NIH HHS/United States GR - R01 ES028277/ES/NIEHS NIH HHS/United States GR - R01 ES024381/ES/NIEHS NIH HHS/United States GR - R25 CA134286/CA/NCI NIH HHS/United States GR - P20 GM104416/GM/NIGMS NIH HHS/United States GR - R01 ES014575/ES/NIEHS NIH HHS/United States GR - P30 ES013508/ES/NIEHS NIH HHS/United States GR - R01 ES025214/ES/NIEHS NIH HHS/United States GR - R01 ES020349/ES/NIEHS NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural PT - Research Support, U.S. Gov't, Non-P.H.S. DEP - 20200316 PL - Netherlands TA - Environ Res JT - Environmental research JID - 0147621 RN - 0 (Environmental Pollutants) RN - 0 (Fluorocarbons) RN - 0 (Thyroid Hormones) SB - IM MH - Bayes Theorem MH - Child MH - *Environmental Pollutants MH - Female MH - *Fluorocarbons MH - Humans MH - Ohio MH - Pregnancy MH - Prospective Studies MH - Thyroid Hormones PMC - PMC7657649 MID - NIHMS1579947 OTO - NOTNLM OT - Epidemiology OT - Mixture models OT - Perfluoroalkyl substances (PFAS) OT - Pregnancy OT - Thyroid hormones COIS- Competing Financial Interests: The authors have no competing financial interests. EDAT- 2020/03/31 06:00 MHDA- 2020/11/21 06:00 PMCR- 2021/06/01 CRDT- 2020/03/31 06:00 PHST- 2019/10/04 00:00 [received] PHST- 2020/03/12 00:00 [revised] PHST- 2020/03/13 00:00 [accepted] PHST- 2020/03/31 06:00 [pubmed] PHST- 2020/11/21 06:00 [medline] PHST- 2020/03/31 06:00 [entrez] PHST- 2021/06/01 00:00 [pmc-release] AID - S0013-9351(20)30288-7 [pii] AID - 10.1016/j.envres.2020.109395 [doi] PST - ppublish SO - Environ Res. 2020 Jun;185:109395. doi: 10.1016/j.envres.2020.109395. Epub 2020 Mar 16.