PMID- 32222773
OWN - NLM
STAT- MEDLINE
DCOM- 20210722
LR  - 20210722
IS  - 1758-535X (Electronic)
IS  - 1079-5006 (Linking)
VI  - 76
IP  - 3
DP  - 2021 Feb 25
TI  - Differential Responses of White Adipose Tissue and Brown Adipose Tissue to 
      Calorie Restriction During Aging.
PG  - 393-399
LID - 10.1093/gerona/glaa070 [doi]
AB  - Age-related adipose tissue dysfunction is potentially important in the 
      development of insulin resistance and metabolic disorder. Caloric restriction 
      (CR) is a robust intervention to reduce adiposity, improve metabolic health, and 
      extend healthy life span. Both white adipose tissue (WAT) and brown adipose 
      tissue (BAT) are involved in energy homeostasis. CR triggers the beiging of WAT 
      in young mice; however, the effects of CR on beiging of WAT and function of BAT 
      during aging are unclear. This study aimed to investigate how age and CR impact 
      the beiging of WAT, the function of BAT, and metabolic health in mice. C57BL/6 
      mice were fed CR diet (40% less than the ad libitum [AL] diet) for 3 months 
      initiated in young (3 months), middle-aged (12 months), and old (19 months) 
      stage. We found age-related changes in different types of adipose tissue, 
      including adipocyte enlargement, declined beiging of WAT, and declined 
      thermogenic and beta-oxidational function of BAT. Moreover, CR attenuated 
      age-associated adipocyte enlargement and prevented the age-related decline in 
      beiging potential of WAT. These protective effects on the beiging potential were 
      significant in inguinal WAT at all three ages, which were significant in 
      epididymal WAT at young and old age. In contrast, thermogenic and beta-oxidational 
      function of BAT further declined after CR in the young age group. In conclusion, 
      our findings reveal the contribution of WAT beiging decline to age-related 
      metabolic disorder and suggest nutritional intervention, specifically targeting 
      WAT beiging, as an effective approach to metabolic health during aging.
CI  - (c) The Author(s) 2020. Published by Oxford University Press on behalf of The 
      Gerontological Society of America. All rights reserved. For permissions, please 
      e-mail: journals.permissions@oup.com.
FAU - Sheng, Yunlu
AU  - Sheng Y
AD  - Division of Geriatric Endocrinology, the First Affiliated Hospital of Nanjing 
      Medical University, People's Republic of China.
FAU - Xia, Fan
AU  - Xia F
AD  - Division of Geriatric Endocrinology, the First Affiliated Hospital of Nanjing 
      Medical University, People's Republic of China.
FAU - Chen, Lei
AU  - Chen L
AD  - Division of Geriatric Respiratory, the First Affiliated Hospital of Nanjing 
      Medical University, People's Republic of China.
FAU - Lv, Yifan
AU  - Lv Y
AD  - Division of Geriatric Endocrinology, the First Affiliated Hospital of Nanjing 
      Medical University, People's Republic of China.
FAU - Lv, Shan
AU  - Lv S
AD  - Division of Geriatric Endocrinology, the First Affiliated Hospital of Nanjing 
      Medical University, People's Republic of China.
FAU - Yu, Jing
AU  - Yu J
AD  - Division of Geriatric Endocrinology, the First Affiliated Hospital of Nanjing 
      Medical University, People's Republic of China.
FAU - Liu, Juan
AU  - Liu J
AD  - Division of Geriatric Endocrinology, the First Affiliated Hospital of Nanjing 
      Medical University, People's Republic of China.
FAU - Ding, Guoxian
AU  - Ding G
AD  - Division of Geriatric Endocrinology, the First Affiliated Hospital of Nanjing 
      Medical University, People's Republic of China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Gerontol A Biol Sci Med Sci
JT  - The journals of gerontology. Series A, Biological sciences and medical sciences
JID - 9502837
SB  - IM
MH  - Adipocytes/pathology
MH  - Adipose Tissue, Brown/*metabolism/*pathology
MH  - Adipose Tissue, White/*metabolism/*pathology
MH  - Aging/*physiology
MH  - Animals
MH  - *Caloric Restriction
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Models, Animal
OTO - NOTNLM
OT  - BAT
OT  - Beiging
OT  - Calorie restriction
OT  - eWAT
OT  - iWAT
EDAT- 2020/03/31 06:00
MHDA- 2021/07/23 06:00
CRDT- 2020/03/31 06:00
PHST- 2019/06/12 00:00 [received]
PHST- 2020/03/31 06:00 [pubmed]
PHST- 2021/07/23 06:00 [medline]
PHST- 2020/03/31 06:00 [entrez]
AID - 5813438 [pii]
AID - 10.1093/gerona/glaa070 [doi]
PST - ppublish
SO  - J Gerontol A Biol Sci Med Sci. 2021 Feb 25;76(3):393-399. doi: 
      10.1093/gerona/glaa070.