PMID- 32222806
OWN - NLM
STAT- MEDLINE
DCOM- 20210511
LR  - 20210511
IS  - 1437-160X (Electronic)
IS  - 0172-8172 (Linking)
VI  - 40
IP  - 8
DP  - 2020 Aug
TI  - Association between statin use and incidence of relapse in anti-neutrophil 
      cytoplasmic antibody-associated vasculitis: a single-center retrospective cohort 
      study.
PG  - 1291-1299
LID - 10.1007/s00296-020-04562-z [doi]
AB  - Several studies have shown the efficacy of statins for some autoimmune disorders 
      caused by anti-inflammatory and immunomodulatory reactions. However, little 
      information is available about the impact of statins on relapse in antineutrophil 
      cytoplasmic antibody-associated vasculitis (AAV). We performed the first 
      investigation examining whether statin use has an effect on suppressing the first 
      relapse of AAV in Japanese patients with AAV. This single-center retrospective 
      cohort study included 98 consecutive patients with newly diagnosed AAV from Aichi 
      Medical University Hospital, Japan between March 2009 and December 2017. Time to 
      first relapse from the first remission was compared between 36 patients in the 
      statin group and 62 patients in the non-statin group using multivariate Cox 
      proportional hazard models, which were adjusted for clinically relevant factors. 
      During the follow-up period (median, 24 months; interquartile range, 
      9-50 months), 35 (97.2%) patients in the statin group achieved remission, whereas 
      56 (90.3%) patients achieved remission in the non-statin group (P = 0.201). After 
      achieving the first remission, 9 (25.7%) patients in the statin group and 29 
      (51.8%) patients in the non-statin group had at least one relapse. Multivariate 
      Cox proportional hazard models revealed that statin use was significantly 
      associated with a lower incidence of relapse compared with non-statin use 
      (multivariate-adjusted hazard ratio = 0.41, 95% confidence interval: 0.18-0.92; 
      P = 0.031). Patients with statin use were associated with a lower incidence of 
      relapse in AAV. Our results should be assessed in well-designed randomized 
      controlled trials.
FAU - Yamaguchi, Makoto
AU  - Yamaguchi M
AUID- ORCID: 0000-0001-7403-9344
AD  - Department of Nephrology and Rheumatology, Aichi Medical University, 1-1 
      Karimata, Yazako, Nagakute, 480-1195, Japan.
FAU - Katsuno, Takayuki
AU  - Katsuno T
AUID- ORCID: 0000-0003-1555-392X
AD  - Department of Nephrology and Rheumatology, Aichi Medical University, 1-1 
      Karimata, Yazako, Nagakute, 480-1195, Japan.
FAU - Iwagaitsu, Shiho
AU  - Iwagaitsu S
AUID- ORCID: 0000-0002-7187-0463
AD  - Department of Nephrology and Rheumatology, Aichi Medical University, 1-1 
      Karimata, Yazako, Nagakute, 480-1195, Japan.
FAU - Nobata, Hironobu
AU  - Nobata H
AUID- ORCID: 0000-0003-1075-1177
AD  - Department of Nephrology and Rheumatology, Aichi Medical University, 1-1 
      Karimata, Yazako, Nagakute, 480-1195, Japan.
FAU - Kinashi, Hiroshi
AU  - Kinashi H
AUID- ORCID: 0000-0002-8657-2389
AD  - Department of Nephrology and Rheumatology, Aichi Medical University, 1-1 
      Karimata, Yazako, Nagakute, 480-1195, Japan.
FAU - Banno, Shogo
AU  - Banno S
AUID- ORCID: 0000-0002-4376-5770
AD  - Department of Nephrology and Rheumatology, Aichi Medical University, 1-1 
      Karimata, Yazako, Nagakute, 480-1195, Japan.
FAU - Ito, Yasuhiko
AU  - Ito Y
AUID- ORCID: 0000-0002-9676-6961
AD  - Department of Nephrology and Rheumatology, Aichi Medical University, 1-1 
      Karimata, Yazako, Nagakute, 480-1195, Japan. yasuito@aichi-med-u.ac.jp.
LA  - eng
PT  - Journal Article
PT  - Observational Study
DEP - 20200328
PL  - Germany
TA  - Rheumatol Int
JT  - Rheumatology international
JID - 8206885
RN  - 0 (Hydroxymethylglutaryl-CoA Reductase Inhibitors)
SB  - IM
MH  - Aged
MH  - Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis/*drug 
      therapy/immunology
MH  - Case-Control Studies
MH  - Female
MH  - Humans
MH  - Hydroxymethylglutaryl-CoA Reductase Inhibitors/*therapeutic use
MH  - Japan
MH  - Male
MH  - Middle Aged
MH  - Proportional Hazards Models
MH  - Recurrence
MH  - Remission Induction/*methods
MH  - Retrospective Studies
MH  - Time Factors
OTO - NOTNLM
OT  - Anti-neutrophil cytoplasmic autoantibody
OT  - Antineutrophil cytoplasmic antibody
OT  - Antineutrophil cytoplasmic antibody-associated vasculitis
OT  - Relapse
OT  - Statin
EDAT- 2020/03/31 06:00
MHDA- 2021/05/12 06:00
CRDT- 2020/03/31 06:00
PHST- 2019/10/30 00:00 [received]
PHST- 2020/03/21 00:00 [accepted]
PHST- 2020/03/31 06:00 [pubmed]
PHST- 2021/05/12 06:00 [medline]
PHST- 2020/03/31 06:00 [entrez]
AID - 10.1007/s00296-020-04562-z [pii]
AID - 10.1007/s00296-020-04562-z [doi]
PST - ppublish
SO  - Rheumatol Int. 2020 Aug;40(8):1291-1299. doi: 10.1007/s00296-020-04562-z. Epub 
      2020 Mar 28.