PMID- 32224340
OWN - NLM
STAT- MEDLINE
DCOM- 20201120
LR  - 20201120
IS  - 1096-0953 (Electronic)
IS  - 0013-9351 (Linking)
VI  - 185
DP  - 2020 Jun
TI  - Historical exposure to non-persistent environmental pollutants and risk of type 2 
      diabetes in a Spanish sub-cohort from the European Prospective Investigation into 
      Cancer and Nutrition study.
PG  - 109383
LID - S0013-9351(20)30276-0 [pii]
LID - 10.1016/j.envres.2020.109383 [doi]
AB  - BACKGROUND: Environmental factors are believed to account for a substantial 
      burden of type 2 diabetes mellitus (T2DM). Non-persistent environmental 
      pollutants (npEPs) are a group of widely-used chemicals identified as 
      endocrine/metabolic disrupting chemicals and obesogens. The aim of this study was 
      to analyse the potential associations of serum levels of three groups of npEPs 
      with the risk of incident T2DM. METHODS: This is a longitudinal study within a 
      sub-sample of Granada EPIC-Spain cohort (n = 670). We quantified serum 
      concentrations of 7 npEPs: four parabens (Methylparaben (MP) ethylparaben (EP), 
      propylparaben (PP) and butilparaben (BP); two benzophenones: Benzophenone 1 
      (BP1), Benzophenone 3 (BP3); and Bisphenol A (BPA). Exposure was assessed by 
      means of chemical analyses of serum samples collected at recruitment, and 
      information on potential confounders was gathered by using validated 
      questionnaires at baseline. Follow-up was performed by review of patients' 
      clinical records. Cox Proportional Hazards Models were used for the statistical 
      analyses. RESULTS: Median follow-up time was 23 years. There were 182 (27%) 
      incident T2DM diagnoses in our sub-cohort. MP was the most frequently detected 
      npEP, 88.42% samples above the limit of detection, and BP showed the lowest 
      percentage of detection (19.21%). Those individuals within the fourth PP quartile 
      (0.53-9.24 ng/ml) showed a statistically significant increased risk of T2DM 
      (HR = 1.668 p = 0.012), while BP1 concentrations showed an inverse 
      non-significant trend with the risk. CONCLUSIONS: We evidenced a potential 
      contribution of npEP exposure on T2DM, but no clear trend was observed. However, 
      limitations in relation to exposure estimation might influence our findings and 
      further research is warranted to confirm our results.
CI  - Copyright (c) 2020 Elsevier Inc. All rights reserved.
FAU - Salamanca-Fernandez, E
AU  - Salamanca-Fernandez E
AD  - Andalusian School of Public Health (EASP), Granada, Spain; Instituto de 
      Investigacion Biosanitaria Ibs.GRANADA, Granada, Spain.
FAU - Iribarne-Duran, L M
AU  - Iribarne-Duran LM
AD  - Instituto de Investigacion Biosanitaria Ibs.GRANADA, Granada, Spain.
FAU - Rodriguez-Barranco, M
AU  - Rodriguez-Barranco M
AD  - Andalusian School of Public Health (EASP), Granada, Spain; Instituto de 
      Investigacion Biosanitaria Ibs.GRANADA, Granada, Spain; CIBER of Epidemiology and 
      Public Health (CIBERESP), Madrid, Spain.
FAU - Vela-Soria, F
AU  - Vela-Soria F
AD  - Instituto de Investigacion Biosanitaria Ibs.GRANADA, Granada, Spain.
FAU - Olea, N
AU  - Olea N
AD  - Instituto de Investigacion Biosanitaria Ibs.GRANADA, Granada, Spain; CIBER of 
      Epidemiology and Public Health (CIBERESP), Madrid, Spain; Department of 
      Radiology, School of Medicine, University of Granada, Granada, Spain.
FAU - Sanchez-Perez, M J
AU  - Sanchez-Perez MJ
AD  - Andalusian School of Public Health (EASP), Granada, Spain; Instituto de 
      Investigacion Biosanitaria Ibs.GRANADA, Granada, Spain; CIBER of Epidemiology and 
      Public Health (CIBERESP), Madrid, Spain.
FAU - Arrebola, J P
AU  - Arrebola JP
AD  - Instituto de Investigacion Biosanitaria Ibs.GRANADA, Granada, Spain; CIBER of 
      Epidemiology and Public Health (CIBERESP), Madrid, Spain; Department of 
      Preventive Medicine and Public Health, University of Granada, Granada, Spain. 
      Electronic address: jparrebola@ugr.es.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20200312
PL  - Netherlands
TA  - Environ Res
JT  - Environmental research
JID - 0147621
RN  - 0 (Environmental Pollutants)
RN  - 0 (Parabens)
SB  - IM
MH  - *Diabetes Mellitus, Type 2/chemically induced/epidemiology
MH  - Environmental Exposure/analysis
MH  - *Environmental Pollutants
MH  - Humans
MH  - Longitudinal Studies
MH  - *Neoplasms
MH  - Parabens/analysis
MH  - Prospective Studies
MH  - Spain/epidemiology
OTO - NOTNLM
OT  - Benzophenones
OT  - Bisphenol A
OT  - Diabetes
OT  - Non-persistent environmental pollutants
OT  - Parabens
COIS- Declaration of competing interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2020/04/01 06:00
MHDA- 2020/11/21 06:00
CRDT- 2020/04/01 06:00
PHST- 2019/12/12 00:00 [received]
PHST- 2020/03/03 00:00 [revised]
PHST- 2020/03/10 00:00 [accepted]
PHST- 2020/04/01 06:00 [pubmed]
PHST- 2020/11/21 06:00 [medline]
PHST- 2020/04/01 06:00 [entrez]
AID - S0013-9351(20)30276-0 [pii]
AID - 10.1016/j.envres.2020.109383 [doi]
PST - ppublish
SO  - Environ Res. 2020 Jun;185:109383. doi: 10.1016/j.envres.2020.109383. Epub 2020 
      Mar 12.