PMID- 32224590
OWN - NLM
STAT- MEDLINE
DCOM- 20200512
LR  - 20200512
IS  - 0485-1439 (Print)
IS  - 0485-1439 (Linking)
VI  - 61
IP  - 3
DP  - 2020
TI  - [Recurrent episodes of hypothermia as a sequela of human herpesvirus 6 
      encephalitis following cord blood transplantation for acute myeloid leukemia].
PG  - 274-279
LID - 10.11406/rinketsu.61.274 [doi]
AB  - A 46-year-old female patient underwent a cord blood transplantation (conditioning 
      regimen: fludarabine/busulfan4/melphalan80; graft-versus-host disease (GVHD) 
      prophylaxis: tacrolimus + mycophenolate mofetil) for acute myeloid leukemia (AML) 
      with her 1st hematological complete response to induction therapy (idarubicin 3 
      days+cytarabine 7 days). She lost her consciousness due to human herpesvirus 6 
      (HHV-6) encephalitis on day 31, and therefore, we increased the foscarnet dosage 
      (from 120 mg/kg to 180 mg/kg). Her consciousness level improved after treatment. 
      However, 8 hours of sudden hypothermia occurred with hyperhidrosis, hypertension, 
      and subsequent hyperglycemia on day 34. Her condition did not improve even after 
      administration of anticonvulsant, steroid pulse, or intravenous immunoglobulin. A 
      total of 75 attacks were observed until she was discharged on day 471. She has 
      not shown chronic GVHD or relapsed AML since then. However, HHV-6 caused 
      prolonged damage to her hypothalamus as observed through magnetic resonance 
      imaging (MRI) and single-photon emission computed tomography (SPECT) using 
      (99m)Tc ethyl cysteinate dimer even when the virus was not detected from her 
      cerebrospinal fluid. This damage can be responsible for the hypothermia attacks. 
      This is the first case report of prolonged series of hypothermia attacks for over 
      a year as a sequela of HHV-6 encephalitis after a cord blood transplantation for 
      AML.
FAU - Sakoh, Takashi
AU  - Sakoh T
AD  - Department of Hematology, Toranomon Hospital Kajigaya.
FAU - Taya, Yuki
AU  - Taya Y
AD  - Department of Hematology, Toranomon Hospital Kajigaya.
FAU - Hirayama, Takehisa
AU  - Hirayama T
AD  - Department of Neurology, Mishuku Hospital.
FAU - Oba, Yuki
AU  - Oba Y
AD  - Department of Diabetes and Metabolism, Toranomon Hospital Kajigaya.
FAU - Mitsuki, Takashi
AU  - Mitsuki T
AD  - Department of Hematology, Toranomon Hospital Kajigaya.
FAU - Nishida, Aya
AU  - Nishida A
AD  - Department of Hematology, Toranomon Hospital Kajigaya.
FAU - Ishiwata, Kazuya
AU  - Ishiwata K
AD  - Department of Hematology, Toranomon Hospital Kajigaya.
FAU - Watanabe, Chizuru
AU  - Watanabe C
AD  - Department of Diabetes and Metabolism, Toranomon Hospital Kajigaya.
FAU - Wake, Atsushi
AU  - Wake A
AD  - Department of Hematology, Toranomon Hospital Kajigaya.
LA  - jpn
PT  - Case Reports
PT  - Journal Article
PL  - Japan
TA  - Rinsho Ketsueki
JT  - [Rinsho ketsueki] The Japanese journal of clinical hematology
JID - 2984782R
RN  - Human Herpesvirus 6 encephalitis
SB  - IM
MH  - *Cord Blood Stem Cell Transplantation
MH  - Encephalitis, Viral
MH  - Female
MH  - *Graft vs Host Disease
MH  - *Hematopoietic Stem Cell Transplantation
MH  - *Herpesvirus 6, Human
MH  - Humans
MH  - *Hypothermia
MH  - *Leukemia, Myeloid, Acute/therapy
MH  - Middle Aged
MH  - Roseolovirus Infections
MH  - Transplantation Conditioning
MH  - Transplantation, Homologous
OTO - NOTNLM
OT  - Cord blood transplantation
OT  - Human herpesvirus 6 (HHV-6) encephalitis
OT  - Hypothalamus
OT  - Hypothermia
EDAT- 2020/04/01 06:00
MHDA- 2020/05/13 06:00
CRDT- 2020/04/01 06:00
PHST- 2020/04/01 06:00 [entrez]
PHST- 2020/04/01 06:00 [pubmed]
PHST- 2020/05/13 06:00 [medline]
AID - 10.11406/rinketsu.61.274 [doi]
PST - ppublish
SO  - Rinsho Ketsueki. 2020;61(3):274-279. doi: 10.11406/rinketsu.61.274.