PMID- 32226344
OWN - NLM
STAT- MEDLINE
DCOM- 20210423
LR  - 20210423
IS  - 1551-4056 (Electronic)
IS  - 0044-0086 (Print)
IS  - 0044-0086 (Linking)
VI  - 93
IP  - 1
DP  - 2020 Mar
TI  - Extracorporeal Photochemotherapy: Mechanistic Insights Driving Recent Advances 
      and Future Directions.
PG  - 145-159
AB  - Dendritic cells (DCs) are professional antigen-presenting cells, necessary for 
      the initiation and maintenance of antigen-specific immunity and tolerance. 
      Decades of research have been driven by hopes to harness the immunological 
      capabilities of DCs and achieve physiological partnership with the immune system 
      for therapeutic ends. Potential applications for DC-based immunotherapy include 
      treatments for cancer, autoimmune disorders, and infectious diseases. However, 
      DCs have poor availability in peripheral and lymphoid tissues and have poor 
      survivability in culture, leading to the development of multiple strategies to 
      generate and manipulate large numbers of DCs ex vivo. Among these is 
      Extracorporeal Photopheresis (ECP), a widely used cancer immunotherapy. Recent 
      advancements have uncovered that stimulation of monocyte-to-DC maturation via 
      physiologic inflammatory signaling lies at the mechanistic core of ECP. Here, we 
      describe the landscape of DC-based immunotherapy, the historical context of ECP, 
      the current mechanistic understanding of ex vivo monocyte-to-DC maturation in 
      ECP, and the implications of this understanding on making scientifically driven 
      improvements to modern ECP protocols and devices.
CI  - Copyright (c)2020, Yale Journal of Biology and Medicine.
FAU - Wei, Brian M
AU  - Wei BM
AD  - Department of Dermatology, Yale School of Medicine, New Haven, CT.
FAU - Hanlon, Douglas
AU  - Hanlon D
AD  - Department of Dermatology, Yale School of Medicine, New Haven, CT.
FAU - Khalil, David
AU  - Khalil D
AD  - Department of Dermatology, Yale School of Medicine, New Haven, CT.
FAU - Han, Patrick
AU  - Han P
AD  - Department of Chemical and Environmental Engineering, School of Engineering and 
      Applied Science, Yale University, New Haven, CT.
FAU - Tatsuno, Kazuki
AU  - Tatsuno K
AD  - Department of Dermatology, Yale School of Medicine, New Haven, CT.
FAU - Sobolev, Olga
AU  - Sobolev O
AD  - Department of Dermatology, Yale School of Medicine, New Haven, CT.
FAU - Edelson, Richard L
AU  - Edelson RL
AD  - Department of Dermatology, Yale School of Medicine, New Haven, CT.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20200327
PL  - United States
TA  - Yale J Biol Med
JT  - The Yale journal of biology and medicine
JID - 0417414
SB  - IM
MH  - Dendritic Cells/*physiology
MH  - Humans
MH  - Immunotherapy/*methods
MH  - *Neoplasms/immunology/therapy
MH  - *Photopheresis/instrumentation/methods
PMC - PMC7087063
OTO - NOTNLM
OT  - Dendritic cell
OT  - Extracorporeal photopheresis
OT  - Immunotherapy
OT  - Platelets
EDAT- 2020/04/01 06:00
MHDA- 2021/04/24 06:00
PMCR- 2020/03/27
CRDT- 2020/04/01 06:00
PHST- 2020/04/01 06:00 [entrez]
PHST- 2020/04/01 06:00 [pubmed]
PHST- 2021/04/24 06:00 [medline]
PHST- 2020/03/27 00:00 [pmc-release]
AID - yjbm931145 [pii]
PST - epublish
SO  - Yale J Biol Med. 2020 Mar 27;93(1):145-159. eCollection 2020 Mar.