PMID- 32226373
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200928
IS  - 1663-4365 (Print)
IS  - 1663-4365 (Electronic)
IS  - 1663-4365 (Linking)
VI  - 11
DP  - 2019
TI  - The Specific Impact of Apolipoprotein E Epsilon 2 on Cognition and Brain Function 
      in Cognitively Normal Elders and Mild Cognitive Impairment Patients.
PG  - 374
LID - 10.3389/fnagi.2019.00374 [doi]
LID - 374
AB  - Variants in the apolipoprotein E (APOE) gene play an important role in the 
      development of Alzheimer's disease (AD). Specifically, the APOE epsilon4 allele is an 
      established genetic risk factor for AD, while the APOE epsilon2 allele is a protective 
      factor against AD. However, the mechanism underlying this impact of APOE genotype 
      on the pathogenesis of AD remain unclear. This study sought to investigate the 
      influence of APOE genotype on cognition and neuroimaging features in cognitively 
      normal (CN) elderly individuals and patients with mild cognitive impairment 
      (MCI). A total of 177 participants were selected from the Alzheimer's Disease 
      Neuroimaging Initiative (ADNI) database, including 101 MCI patients and 76 CN 
      individuals. A 2 x 3 (consisting of two groups and three APOE genotypes) analysis 
      of covariance was carried out to measure the influences of diagnosis and APOE 
      genotype on cognition and brain features, assessed based on global functional 
      connectivity density (gFCD) and hippocampal volume. In addition, a mediation 
      analysis was carried out to investigate the indirect influence of neuroimaging 
      features on the relationship between APOE genotype and cognitive performance in 
      the MCI group. This analysis revealed that APOE genotype had an influence on 
      brain function in the bilateral precentral gyrus, right thalamus, and posterior 
      cingulate cortex (PCC). In addition, an interactive influence between diagnosis 
      and APOE genotype was found on general cognition, immediate memory, executive 
      function, hippocampal volume, and gFCD in the right dorsolateral prefrontal 
      cortex and medial prefrontal cortex (MPFC). Finally, this mediation analysis 
      revealed that hippocampal volume and gFCD in the thalamus may mediate the 
      relationship between APOE genotype and cognitive performance in the MCI group. 
      Taken together, our findings provide novel insights into the neural mechanisms 
      underlying the genetically guided pathogenic mechanisms of AD.
CI  - Copyright (c) 2020 Gong, Xu, Liu, Lan, Zhang and Zhang.
FAU - Gong, Liang
AU  - Gong L
AD  - Department of Neurology, Chengdu Second People's Hospital, Chengdu, China.
FAU - Xu, Ronghua
AU  - Xu R
AD  - Department of Neurology, Chengdu Second People's Hospital, Chengdu, China.
FAU - Liu, Duan
AU  - Liu D
AD  - Department of Neurology, Chengdu Second People's Hospital, Chengdu, China.
FAU - Lan, Lin
AU  - Lan L
AD  - Department of Neurology, Chengdu Second People's Hospital, Chengdu, China.
FAU - Zhang, Bei
AU  - Zhang B
AD  - Department of Neurology, Chengdu Second People's Hospital, Chengdu, China.
FAU - Zhang, Chuantao
AU  - Zhang C
AD  - Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China.
LA  - eng
PT  - Journal Article
DEP - 20200128
PL  - Switzerland
TA  - Front Aging Neurosci
JT  - Frontiers in aging neuroscience
JID - 101525824
PMC - PMC7081769
OTO - NOTNLM
OT  - Alzheimer's disease
OT  - apolipoprotein E
OT  - functional connectivity density
OT  - hippocampus
OT  - imaging genetics
EDAT- 2020/04/01 06:00
MHDA- 2020/04/01 06:01
PMCR- 2019/01/01
CRDT- 2020/04/01 06:00
PHST- 2019/06/07 00:00 [received]
PHST- 2019/12/19 00:00 [accepted]
PHST- 2020/04/01 06:00 [entrez]
PHST- 2020/04/01 06:00 [pubmed]
PHST- 2020/04/01 06:01 [medline]
PHST- 2019/01/01 00:00 [pmc-release]
AID - 10.3389/fnagi.2019.00374 [doi]
PST - epublish
SO  - Front Aging Neurosci. 2020 Jan 28;11:374. doi: 10.3389/fnagi.2019.00374. 
      eCollection 2019.