PMID- 32226609
OWN - NLM
STAT- MEDLINE
DCOM- 20200818
LR  - 20220826
IS  - 2046-1402 (Electronic)
IS  - 2046-1402 (Linking)
VI  - 9
DP  - 2020
TI  - Recent advances in mast cell activation and regulation.
LID - F1000 Faculty Rev-196 [pii]
LID - 10.12688/f1000research.22037.1 [doi]
AB  - Mast cells are innate immune cells that intersect with the adaptive immunity and 
      play a crucial role in the initiation of allergic reactions and the host defense 
      against certain parasites and venoms. When activated in an allergen- and 
      immunoglobulin E (IgE)-dependent manner, these cells secrete a large variety of 
      allergenic mediators that are pre-stored in secretory granules or de 
      novo-synthesized. Traditionally, studies have predominantly focused on 
      understanding this mechanism of mast cell activation and regulation. Along this 
      line of study, recent studies have shed light on what structural features are 
      required for allergens and how IgE, particularly anaphylactic IgE, is produced. 
      However, the last few years have seen a flurry of new studies on IgE-independent 
      mast cell activation, particularly via Mrgprb2 (mouse) and MRGPRX2 (human). These 
      studies have greatly advanced our understanding of how mast cells exert 
      non-histaminergic itch, pain, and drug-induced pseudoallergy by interacting with 
      sensory neurons. Recent studies have also characterized mast cell activation and 
      regulation by interleukin-33 (IL-33) and other cytokines and by non-coding RNAs. 
      These newly identified mechanisms for mast cell activation and regulation will 
      further stimulate the allergy/immunology community to develop novel therapeutic 
      strategies for treatment of allergic and non-allergic diseases.
CI  - Copyright: (c) 2020 Kim HS et al.
FAU - Kim, Hwan Soo
AU  - Kim HS
AUID- ORCID: 0000-0002-5952-7849
AD  - Division of Cell Biology, La Jolla Institute for Immunology, La Jolla, 
      California, 92037, USA.
AD  - Department of Pediatrics, College of Medicine, The Catholic University of Korea, 
      Seoul, South Korea.
FAU - Kawakami, Yu
AU  - Kawakami Y
AD  - Division of Cell Biology, La Jolla Institute for Immunology, La Jolla, 
      California, 92037, USA.
FAU - Kasakura, Kazumi
AU  - Kasakura K
AD  - Division of Cell Biology, La Jolla Institute for Immunology, La Jolla, 
      California, 92037, USA.
FAU - Kawakami, Toshiaki
AU  - Kawakami T
AUID- ORCID: 0000-0002-0427-1217
AD  - Division of Cell Biology, La Jolla Institute for Immunology, La Jolla, 
      California, 92037, USA.
AD  - Department of Dermatlogy, University of California San Diego, School of Medicine, 
      La Jolla, CA, 92093, USA.
LA  - eng
GR  - R01 AI146042/AI/NIAID NIH HHS/United States
GR  - R21 AI153867/AI/NIAID NIH HHS/United States
GR  - T32 AI125179/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20200319
PL  - England
TA  - F1000Res
JT  - F1000Research
JID - 101594320
RN  - 0 (Allergens)
RN  - 0 (Cytokines)
RN  - 0 (MRGPRX2 protein, human)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Receptors, G-Protein-Coupled)
RN  - 0 (Receptors, Neuropeptide)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Allergens
MH  - Animals
MH  - Cytokines
MH  - Humans
MH  - Immunoglobulin E
MH  - *Mast Cells
MH  - Nerve Tissue Proteins
MH  - Receptors, G-Protein-Coupled
MH  - Receptors, Neuropeptide
PMC - PMC7096214
OTO - NOTNLM
OT  - Allergy
OT  - FcepsilonRI
OT  - IL-33
OT  - IgE
OT  - MRGPRX2
OT  - allergen
OT  - mast cells
OT  - miRNA
COIS- No competing interests were disclosed.No competing interests were disclosed.No 
      competing interests were disclosed.
EDAT- 2020/04/01 06:00
MHDA- 2020/08/19 06:00
PMCR- 2020/03/19
CRDT- 2020/04/01 06:00
PHST- 2020/03/06 00:00 [accepted]
PHST- 2020/04/01 06:00 [entrez]
PHST- 2020/04/01 06:00 [pubmed]
PHST- 2020/08/19 06:00 [medline]
PHST- 2020/03/19 00:00 [pmc-release]
AID - F1000 Faculty Rev-196 [pii]
AID - 10.12688/f1000research.22037.1 [doi]
PST - epublish
SO  - F1000Res. 2020 Mar 19;9:F1000 Faculty Rev-196. doi: 
      10.12688/f1000research.22037.1. eCollection 2020.