PMID- 32227291
OWN - NLM
STAT- MEDLINE
DCOM- 20210101
LR  - 20210101
IS  - 1432-119X (Electronic)
IS  - 0948-6143 (Linking)
VI  - 154
IP  - 2
DP  - 2020 Aug
TI  - Nano-curcumin versus curcumin in amelioration of deltamethrin-induced hippocampal 
      damage.
PG  - 157-175
LID - 10.1007/s00418-020-01871-z [doi]
AB  - We aimed to prove that oxidative stress is the main mechanism responsible for 
      hippocampal neurotoxicity induced by deltamethrin (DLM). The protective role of 
      curcumin (CMN) and nano-curcumin (NCMN) over this toxicity was studied. The rats 
      were categorized into four groups: control, DLM, CMN and NCMN. The study 
      continued for 30 days. Hippocampus was processed for histological, biochemical 
      and immunohistochemical studies. Caspase-3, glial fibrillar acidic protein 
      (GFAP), acetylcholinesterase (AChE), malondialdehyde (MDA), glutathione (GSH), 
      catalase (CAT) and superoxide dismutase (SOD) were measured for DLM-induced 
      oxidative stress (increased MDA by 354%/decreased GSH by 61%, SOD by 61%, CAT 
      57%). Oxidative stress induced apoptosis of hippocampal neurons through 
      increasing Nrf2, gamma-glutamyl cysteine synthetase heavy subunit (GCS-HS) and 
      light subunit (GCS-LS) and decreasing AChE. It increases the activity of 
      astrocytes through increasing GFAP. Finally, oxidative stress has a bad impaction 
      on cognitive function. Improvement of oxidative stress was observed with use of 
      CMN and NCMN (decrease of MDA/increase of GSH, SOD, CAT). The level of Nrf2, 
      GCS-HS and GCS-LS decreased, while AChE, GFAP increased. Improvement of cognitive 
      function was observed in both groups. In conclusion, oxidative stress is the 
      common mechanism responsible for DLM-induced hippocampal neurotoxicity. It exerts 
      apoptosis of hippocampal neurons through increasing Nrf2, HS-GCS, LS-GCS and 
      decreasing AChE. In addition, it activates astrocytes through increasing 
      expression of GFAP. The protective role of CMN and CMMN is related to their 
      potent antioxidant effect. Much improvement has been detected with NCMN as 
      compared to CMN.
FAU - Zaki, Sherif Mohamed
AU  - Zaki SM
AD  - Department of Anatomy and Embryology, Faculty of Medicine, Cairo University, 
      Giza, Egypt. zakysherif1@gmail.com.
AD  - Fakeeh College for Medical Sciences, Jeddah, Saudi Arabia. zakysherif1@gmail.com.
FAU - Algaleel, Waleed Ahmed Abd
AU  - Algaleel WAA
AD  - Department of Anatomy and Embryology, Faculty of Medicine, Cairo University, 
      Giza, Egypt.
AD  - Faculty of Medicine, Cairo University, Giza, Egypt.
FAU - Imam, Reda Abdelnasser
AU  - Imam RA
AD  - Department of Anatomy and Embryology, Faculty of Medicine, Cairo University, 
      Giza, Egypt.
AD  - Faculty of Medicine, Cairo University, Giza, Egypt.
FAU - Soliman, Ghada F
AU  - Soliman GF
AD  - Department of Pharmacology, Faculty of Medicine, Cairo University, Giza, Egypt.
AD  - Faculty of Medicine, Cairo University, Giza, Egypt.
FAU - Ghoneim, Fatma M
AU  - Ghoneim FM
AD  - Department of Histology and Cell Biology, Faculty of Medicine, Mansoura 
      University, Mansoura, Egypt.
AD  - Faculty of Medicine, Mansoura University, Mansoura, Egypt.
LA  - eng
PT  - Journal Article
DEP - 20200329
PL  - Germany
TA  - Histochem Cell Biol
JT  - Histochemistry and cell biology
JID - 9506663
RN  - 0 (Antioxidants)
RN  - 0 (Insecticides)
RN  - 0 (Nitriles)
RN  - 0 (Protective Agents)
RN  - 0 (Pyrethrins)
RN  - 2JTS8R821G (decamethrin)
RN  - IT942ZTH98 (Curcumin)
SB  - IM
MH  - Animals
MH  - Antioxidants/chemistry/*pharmacology
MH  - Apoptosis/drug effects
MH  - Curcumin/chemistry/*pharmacology
MH  - Hippocampus/*drug effects/metabolism/pathology
MH  - Insecticides/antagonists & inhibitors/pharmacology
MH  - Maze Learning/drug effects
MH  - Nanoparticles/*chemistry
MH  - Neurons/drug effects/metabolism/pathology
MH  - Nitriles/antagonists & inhibitors/pharmacology
MH  - Oxidative Stress/drug effects
MH  - Protective Agents/chemistry/*pharmacology
MH  - Pyrethrins/antagonists & inhibitors/pharmacology
MH  - Rats
MH  - Rats, Wistar
OTO - NOTNLM
OT  - Curcumin
OT  - Deltamethrin
OT  - Hippocampus
OT  - Nano-curcumin
EDAT- 2020/04/01 06:00
MHDA- 2021/01/02 06:00
CRDT- 2020/04/01 06:00
PHST- 2020/03/10 00:00 [accepted]
PHST- 2020/04/01 06:00 [pubmed]
PHST- 2021/01/02 06:00 [medline]
PHST- 2020/04/01 06:00 [entrez]
AID - 10.1007/s00418-020-01871-z [pii]
AID - 10.1007/s00418-020-01871-z [doi]
PST - ppublish
SO  - Histochem Cell Biol. 2020 Aug;154(2):157-175. doi: 10.1007/s00418-020-01871-z. 
      Epub 2020 Mar 29.