PMID- 32228975
OWN - NLM
STAT- MEDLINE
DCOM- 20201224
LR  - 20201224
IS  - 1873-0191 (Electronic)
IS  - 0928-4931 (Linking)
VI  - 109
DP  - 2020 Apr
TI  - Study on the release behaviors of berberine hydrochloride based on sandwich 
      nanostructure and shape memory effect.
PG  - 110541
LID - S0928-4931(19)32872-3 [pii]
LID - 10.1016/j.msec.2019.110541 [doi]
AB  - Nanofibrous drug delivery systems (DDSs) recently have attracted remarkable 
      interest, especially their potential to program dosage of the encased drug 
      intelligently. Despite this, the exploration of efficient strategy to precisely 
      program drug release from nanofibrous DDS still remains a significant challenge. 
      In this study, we electrospun a near-body temperature (T(trans)  approximately  42  degrees C) 
      sensitive shape memory polyurethane in three stages through sequential 
      electrospinning technology, and prepared a sort of sandwich structural membrane, 
      comprising of top, inner and bottom layers, wherein a natural antibacterial 
      agent, berberine hydrochloride (BCH), was imbedded inside the middle layer. As 
      demonstrated by the results obtained from tensile testing and morphology 
      characterization, the prepared sandwich structural membrane and the nanofibrous 
      membrane with homogenous structure exhibited not only desirable mechanical 
      properties but also surface morphologies. In addition, the release period can be 
      significantly prolonged in virtue of the sandwich structure. As revealed by the 
      experiment of in vitro drug release, it took nearly 144 h to release 80 wt% BCH 
      from sandwich structural membrane, while as little as 72 h was observed to 
      release the same amount of BCH from that with homogenous structure. More 
      interestingly, the encapsulated BCH is capable to be released in a controlled 
      manner owning to the thermo-sensitive shape memory effect, and the release rate 
      of BCH can be accelerated by stretching and fixing the nanofibrous membranes into 
      certain ratios prior to release. Collectively, this study provides a facile 
      strategy to design and prepare a reliable and smart DDS, i.e. sandwich structural 
      membrane, which may enhance the availability of BCH and also intelligently avoid 
      the bacterial infection.
CI  - Copyright (c) 2019 Elsevier B.V. All rights reserved.
FAU - Yin, Xueqian
AU  - Yin X
AD  - College of Biomass Science and Engineering, Sichuan University, Cheng Du 610065, 
      China.
FAU - Tan, Pengfei
AU  - Tan P
AD  - College of Biomass Science and Engineering, Sichuan University, Cheng Du 610065, 
      China.
FAU - Luo, Hao
AU  - Luo H
AD  - College of Biomass Science and Engineering, Sichuan University, Cheng Du 610065, 
      China.
FAU - Lan, Jianwu
AU  - Lan J
AD  - College of Biomass Science and Engineering, Sichuan University, Cheng Du 610065, 
      China.
FAU - Shi, Yidong
AU  - Shi Y
AD  - College of Biomass Science and Engineering, Sichuan University, Cheng Du 610065, 
      China.
FAU - Zhang, Yong
AU  - Zhang Y
AD  - College of Biomass Science and Engineering, Sichuan University, Cheng Du 610065, 
      China.
FAU - Fan, Haojun
AU  - Fan H
AD  - College of Biomass Science and Engineering, Sichuan University, Cheng Du 610065, 
      China; Key Laboratory of Leather Chemistry and Engineering of Ministry of 
      Education, Sichuan University, Chengdu 610065, China.
FAU - Tan, Lin
AU  - Tan L
AD  - College of Biomass Science and Engineering, Sichuan University, Cheng Du 610065, 
      China; Key Laboratory of Leather Chemistry and Engineering of Ministry of 
      Education, Sichuan University, Chengdu 610065, China. Electronic address: 
      tanlinou@scu.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20191212
PL  - Netherlands
TA  - Mater Sci Eng C Mater Biol Appl
JT  - Materials science & engineering. C, Materials for biological applications
JID - 101484109
RN  - 0 (Delayed-Action Preparations)
RN  - 0 (Smart Materials)
RN  - 0I8Y3P32UF (Berberine)
SB  - IM
MH  - *Berberine/chemistry/pharmacokinetics
MH  - Delayed-Action Preparations/chemistry/pharmacokinetics
MH  - Nanostructures/*chemistry
MH  - *Smart Materials/chemistry/pharmacokinetics
OTO - NOTNLM
OT  - Antibacterial performance
OT  - Multilayer nanostructure
OT  - Programmable release
OT  - Shape memory effect
COIS- Declaration of competing interest We declare that we have no financial and 
      personal relationships with other people or organizations that can 
      inappropriately influence our work, there is no professional or other personal 
      interest of any nature or kind in any product, service/and/or company that could 
      be construed as influencing the position presented in, or the review of the 
      manuscript entitled.
EDAT- 2020/04/02 06:00
MHDA- 2020/12/29 06:00
CRDT- 2020/04/02 06:00
PHST- 2019/08/05 00:00 [received]
PHST- 2019/12/02 00:00 [revised]
PHST- 2019/12/10 00:00 [accepted]
PHST- 2020/04/02 06:00 [entrez]
PHST- 2020/04/02 06:00 [pubmed]
PHST- 2020/12/29 06:00 [medline]
AID - S0928-4931(19)32872-3 [pii]
AID - 10.1016/j.msec.2019.110541 [doi]
PST - ppublish
SO  - Mater Sci Eng C Mater Biol Appl. 2020 Apr;109:110541. doi: 
      10.1016/j.msec.2019.110541. Epub 2019 Dec 12.