PMID- 32229213
OWN - NLM
STAT- MEDLINE
DCOM- 20210219
LR  - 20210219
IS  - 1879-0003 (Electronic)
IS  - 0141-8130 (Linking)
VI  - 155
DP  - 2020 Jul 15
TI  - Development and characterization of a photo-cross-linked functionalized type-I 
      collagen (Oreochromis niloticus) and polyethylene glycol diacrylate hydrogel.
PG  - 163-173
LID - S0141-8130(20)32796-3 [pii]
LID - 10.1016/j.ijbiomac.2020.03.210 [doi]
AB  - Collagen hydrogels have been widely investigated as scaffolds for tissue 
      engineering due to their biocompatibility and capacity to promote cell adhesion. 
      However, insufficient mechanical strength and rapid degradation properties remain 
      the major obstacles for their applications. In the present study, type-I tilapia 
      collagen (TC) was functionalized to form methacrylated tilapia collagen (MATC) by 
      introducing methacrylic acid, developing a photo-cross-linked PEGDA-MATC 
      hydrogel. The mechanical strength of PEGDA-MATC hydrogel could be tuned by 
      adjusting the pH of the precursor solutions, which was decreased with the pH 
      increased. At a pH 5 condition, PEGDA-MATC showed the highest compressive 
      fracture stress (1.31 MPa). Compared to the PEGDA-TC hydrogel, PEGDA-MATC 
      hydrogel exhibited similar swelling behavior to PEGDA-TC hydrogel in PBS 
      solutions, but higher residual mass ratio (PEGDA-MATC, 213.2 +/- 2.8%) than 
      PEGDA-TC hydrogel (199.4 +/- 3.8%) when cultured with type-I collagenase. 
      PEGDA-MATC hydrogel showed sustained BSA release capacity for 6 days, and the BSA 
      release ratio was significantly (p < 0.05) decreased with increasing 
      concentration of loaded-BSA (68.6% at 4 mg mL(-1), 42.2% at 8 mg mL(-1)). The 
      PEGDA-MATC hydrogel allowed cell adhesion and proliferation in vitro. These 
      results demonstrated that PEGDA-MATC hydrogel might be a potential scaffold for 
      tissue engineering applications.
CI  - Copyright (c) 2020 Elsevier B.V. All rights reserved.
FAU - Bao, Zixian
AU  - Bao Z
AD  - CAS Key Laboratory of Biobased Materials, Qingdao Institute of Bioenergy and 
      Bioprocess Technology, Chinese Academy of Sciences, No. 189 Songling Road, 
      Qingdao 266101, China.
FAU - Gao, Minghong
AU  - Gao M
AD  - CAS Key Laboratory of Biobased Materials, Qingdao Institute of Bioenergy and 
      Bioprocess Technology, Chinese Academy of Sciences, No. 189 Songling Road, 
      Qingdao 266101, China.
FAU - Fan, Xiying
AU  - Fan X
AD  - CAS Key Laboratory of Biobased Materials, Qingdao Institute of Bioenergy and 
      Bioprocess Technology, Chinese Academy of Sciences, No. 189 Songling Road, 
      Qingdao 266101, China; University of Chinese Academy of Sciences, No. 19(A) 
      Yuquan Road, Beijing 100049, China.
FAU - Cui, Yuting
AU  - Cui Y
AD  - CAS Key Laboratory of Biobased Materials, Qingdao Institute of Bioenergy and 
      Bioprocess Technology, Chinese Academy of Sciences, No. 189 Songling Road, 
      Qingdao 266101, China.
FAU - Yang, Junqing
AU  - Yang J
AD  - CAS Key Laboratory of Biobased Materials, Qingdao Institute of Bioenergy and 
      Bioprocess Technology, Chinese Academy of Sciences, No. 189 Songling Road, 
      Qingdao 266101, China.
FAU - Peng, Xinying
AU  - Peng X
AD  - CAS Key Laboratory of Biobased Materials, Qingdao Institute of Bioenergy and 
      Bioprocess Technology, Chinese Academy of Sciences, No. 189 Songling Road, 
      Qingdao 266101, China; University of Chinese Academy of Sciences, No. 19(A) 
      Yuquan Road, Beijing 100049, China.
FAU - Xian, Mo
AU  - Xian M
AD  - CAS Key Laboratory of Biobased Materials, Qingdao Institute of Bioenergy and 
      Bioprocess Technology, Chinese Academy of Sciences, No. 189 Songling Road, 
      Qingdao 266101, China.
FAU - Sun, Yue
AU  - Sun Y
AD  - CAS Key Laboratory of Biobased Materials, Qingdao Institute of Bioenergy and 
      Bioprocess Technology, Chinese Academy of Sciences, No. 189 Songling Road, 
      Qingdao 266101, China. Electronic address: sunyue@qibebt.ac.cn.
FAU - Nian, Rui
AU  - Nian R
AD  - CAS Key Laboratory of Biobased Materials, Qingdao Institute of Bioenergy and 
      Bioprocess Technology, Chinese Academy of Sciences, No. 189 Songling Road, 
      Qingdao 266101, China. Electronic address: nianrui@qibebt.ac.cn.
LA  - eng
PT  - Journal Article
DEP - 20200327
PL  - Netherlands
TA  - Int J Biol Macromol
JT  - International journal of biological macromolecules
JID - 7909578
RN  - 0 (Biocompatible Materials)
RN  - 0 (Collagen Type I)
RN  - 0 (Hydrogels)
RN  - 0 (poly(ethylene glycol)diacrylate)
RN  - 3WJQ0SDW1A (Polyethylene Glycols)
SB  - IM
MH  - Animals
MH  - Biocompatible Materials/*chemistry
MH  - Cell Adhesion
MH  - Cell Line
MH  - Cichlids
MH  - Collagen Type I/*chemistry
MH  - Hydrogels/*chemistry
MH  - Mice
MH  - Polyethylene Glycols/*chemistry
MH  - Tissue Engineering
MH  - Tissue Scaffolds/*chemistry
OTO - NOTNLM
OT  - Cell adhesion
OT  - Mechanical strength
OT  - Methacrylated collagen
OT  - Photo-cross-linking
OT  - Polyethylene glycol diacrylate
EDAT- 2020/04/02 06:00
MHDA- 2021/02/20 06:00
CRDT- 2020/04/02 06:00
PHST- 2019/12/20 00:00 [received]
PHST- 2020/03/24 00:00 [revised]
PHST- 2020/03/24 00:00 [accepted]
PHST- 2020/04/02 06:00 [pubmed]
PHST- 2021/02/20 06:00 [medline]
PHST- 2020/04/02 06:00 [entrez]
AID - S0141-8130(20)32796-3 [pii]
AID - 10.1016/j.ijbiomac.2020.03.210 [doi]
PST - ppublish
SO  - Int J Biol Macromol. 2020 Jul 15;155:163-173. doi: 
      10.1016/j.ijbiomac.2020.03.210. Epub 2020 Mar 27.