PMID- 32231383
OWN - NLM
STAT- MEDLINE
DCOM- 20200629
LR  - 20240328
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 15
IP  - 3
DP  - 2020
TI  - Undernutrition combined with dietary mineral oil hastens depuration of stored 
      dioxin and polychlorinated biphenyls in ewes. 2. Tissue distribution, mass 
      balance and body burden.
PG  - e0230628
LID - 10.1371/journal.pone.0230628 [doi]
LID - e0230628
AB  - Food safety crises involving persistent organic pollutants (POPs) lead to 
      systematic slaughter of livestock to prevent contaminants from entering the food 
      chain. Therefore, there is a need to develop strategies to depurate livestock 
      moderately contaminated with POPs to reduce economic and social damage. This 
      study aimed to test undernutrition (37% of energy requirements) combined with 
      mineral oil (10% in total dry matter intake) in nine non-lactating ewes 
      contaminated with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and polychlorinated 
      biphenyls (PCBs) 126 and 153 as a strategy to enhance the depuration of POPs 
      through faecal excretion. To better understand the underlying mechanisms of the 
      depuration process, lipophilic POPs and lipid fluxes were co-monitored in various 
      body and excretion compartments. Body compartments (adipose tissues, muscle, 
      liver and blood) and the total empty body were analyzed for lipids and POPs 
      concentrations and burdens at slaughter, as well as excretion compartments 
      (faeces and wool) collected during the depuration period. Decreases in empty body 
      total and lipid weights were 6-fold higher in underfed and supplemented ewes 
      compared to control ewes. In addition, over the depuration period undernutrition 
      and supplementation treatment increased faecal TCDD, PCBs 126 and 153 excretions 
      by 1.4- to 2.1-fold but tended to decrease wool PCB 153 excretion by 1.4-fold. 
      This induced 2- to 3-fold higher decreases in the empty body POPs burdens for 
      underfed and supplemented ewes. Nonetheless, when expressed relative to the 
      calculated initial empty body burdens, burdens at slaughter decreased only 
      slightly from 97%, 103% and 98% for control ewes to 92%, 97% and 94% for underfed 
      and supplemented ones, for TCDD, PCBs 126 and 153, respectively. Fine 
      descriptions at once of POPs kinetic (companion paper 1) and mass balance 
      (companion paper 2), and of body lipid dynamics were very useful in improving our 
      understanding of the fate of POPs in the ruminants.
FAU - Lerch, Sylvain
AU  - Lerch S
AUID- ORCID: 0000-0003-0957-8012
AD  - UR AFPA, Universite de Lorraine, INRAE, Nancy, France.
AD  - Ruminant Research Unit, Agroscope, Posieux, Switzerland.
FAU - Rey-Cadilhac, Lucille
AU  - Rey-Cadilhac L
AD  - UR AFPA, Universite de Lorraine, INRAE, Nancy, France.
AD  - UMR Herbivores, Universite Clermont Auvergne, INRAE, VetAgro Sup, 
      Saint-Genes-Champanelle, France.
FAU - Cariou, Ronan
AU  - Cariou R
AUID- ORCID: 0000-0002-4669-1834
AD  - LABERCA, Oniris, INRAE, Nantes, France.
FAU - Faulconnier, Yannick
AU  - Faulconnier Y
AD  - UMR Herbivores, Universite Clermont Auvergne, INRAE, VetAgro Sup, 
      Saint-Genes-Champanelle, France.
FAU - Jondreville, Catherine
AU  - Jondreville C
AD  - UR AFPA, Universite de Lorraine, INRAE, Nancy, France.
FAU - Roux, Denis
AU  - Roux D
AD  - UE Herbipole, INRAE, Saint-Genes-Champanelle, France.
FAU - Dervilly-Pinel, Gaud
AU  - Dervilly-Pinel G
AD  - LABERCA, Oniris, INRAE, Nantes, France.
FAU - Le Bizec, Bruno
AU  - Le Bizec B
AD  - LABERCA, Oniris, INRAE, Nantes, France.
FAU - Jurjanz, Stefan
AU  - Jurjanz S
AD  - UR AFPA, Universite de Lorraine, INRAE, Nancy, France.
FAU - Ferlay, Anne
AU  - Ferlay A
AD  - UMR Herbivores, Universite Clermont Auvergne, INRAE, VetAgro Sup, 
      Saint-Genes-Champanelle, France.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20200331
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (Dietary Fats, Unsaturated)
RN  - 0 (Dioxins)
RN  - 0 (Environmental Pollutants)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
SB  - IM
CIN - Undernutrition combined with dietary mineral oil hastens depuration of stored 
      dioxin and polychlorinated biphenyls in ewes. 1. Kinetics in blood, adipose 
      tissue and faeces.
MH  - Adipose Tissue/*chemistry/metabolism
MH  - Animals
MH  - Body Burden
MH  - Body Weight
MH  - Dietary Fats, Unsaturated/*administration & dosage
MH  - Dioxins/*analysis
MH  - Environmental Pollutants/analysis
MH  - Feces/chemistry
MH  - Liver/*chemistry/metabolism
MH  - Malnutrition/*pathology
MH  - Polychlorinated Biphenyls/*analysis
MH  - Sheep
MH  - Wool/chemistry/metabolism
PMC - PMC7108722
COIS- The authors have declared that no competing interests exist.
EDAT- 2020/04/02 06:00
MHDA- 2020/07/01 06:00
PMCR- 2020/03/31
CRDT- 2020/04/02 06:00
PHST- 2019/10/30 00:00 [received]
PHST- 2020/03/04 00:00 [accepted]
PHST- 2020/04/02 06:00 [entrez]
PHST- 2020/04/02 06:00 [pubmed]
PHST- 2020/07/01 06:00 [medline]
PHST- 2020/03/31 00:00 [pmc-release]
AID - PONE-D-19-30218 [pii]
AID - 10.1371/journal.pone.0230628 [doi]
PST - epublish
SO  - PLoS One. 2020 Mar 31;15(3):e0230628. doi: 10.1371/journal.pone.0230628. 
      eCollection 2020.