PMID- 32231737
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200928
IS  - 1837-9664 (Print)
IS  - 1837-9664 (Electronic)
IS  - 1837-9664 (Linking)
VI  - 11
IP  - 11
DP  - 2020
TI  - Circular RNA MAN2B2 promotes cell proliferation of hepatocellular carcinoma cells 
      via the miRNA-217/MAPK1 axis.
PG  - 3318-3326
LID - 10.7150/jca.36500 [doi]
AB  - The increasing incidence of hepatocellular carcinoma (HCC) is a major challenge 
      worldwide. In the past few years, an increasing number of studies have suggested 
      that circular RNAs (circRNAs) play an important role in the development of human 
      tumors, including HCC, but our understanding of their function is still limited. 
      In this study, we investigated differences in the expression of circRNA MAN2B2 
      (circMAN2B2) in hepatocellular tissues and paired normal tissues. We found that 
      knockdown of circMAN2B2 expression in the HCC cell lines Hep-G2 and Huh-7 
      significantly inhibited cell proliferation by sponging (miRNA) miR-217 and 
      inhibiting its function. Through a series of experiments, we also demonstrated 
      that miR-217 functioned as a tumor suppressor molecule in HCC cells and regulated 
      the expression of mitogen-activated protein kinase 1 (MAPK1). Restoration of 
      MAPK1 rescued repression of cell proliferation induced by circMAN2B2 knockdown. 
      In summary, our study indicated that circMAN2B2 acted as an onco-miRNA in HCC by 
      sponging miRNA-217 to promote MAPK1 expression.
CI  - (c) The author(s).
FAU - Fu, Xiaoying
AU  - Fu X
AD  - Shenzhen Third People's Hospital, Second Affiliated Hospital of Southern 
      University of Science and Technology.
AD  - Shenzhen University.
FAU - Zhang, Juanjuan
AU  - Zhang J
AD  - Shenzhen Third People's Hospital, Second Affiliated Hospital of Southern 
      University of Science and Technology.
FAU - He, Xing
AU  - He X
AD  - Shenzhen Third People's Hospital, Second Affiliated Hospital of Southern 
      University of Science and Technology.
FAU - Yan, Xu
AU  - Yan X
AD  - Shenzhen Third People's Hospital, Second Affiliated Hospital of Southern 
      University of Science and Technology.
FAU - Wei, Jian
AU  - Wei J
AD  - Shenzhen Third People's Hospital, Second Affiliated Hospital of Southern 
      University of Science and Technology.
FAU - Huang, Min
AU  - Huang M
AD  - Shenzhen Third People's Hospital, Second Affiliated Hospital of Southern 
      University of Science and Technology.
FAU - Liu, Yaya
AU  - Liu Y
AD  - Shenzhen Third People's Hospital, Second Affiliated Hospital of Southern 
      University of Science and Technology.
FAU - Lin, Jianwei
AU  - Lin J
AD  - Shenzhen People's Hospital. Shenzhen 518039, China.
FAU - Hu, Hongxing
AU  - Hu H
AD  - Shenzhen Third People's Hospital, Second Affiliated Hospital of Southern 
      University of Science and Technology.
FAU - Liu, Lei
AU  - Liu L
AD  - Shenzhen Third People's Hospital, Second Affiliated Hospital of Southern 
      University of Science and Technology.
LA  - eng
PT  - Journal Article
DEP - 20200305
PL  - Australia
TA  - J Cancer
JT  - Journal of Cancer
JID - 101535920
PMC - PMC7097945
OTO - NOTNLM
OT  - MAPK1
OT  - circMAN2B2
OT  - circular RNA
OT  - hepatocellular carcinoma
OT  - miR-217
COIS- Competing Interests: The authors have declared that no competing interest exists.
EDAT- 2020/04/02 06:00
MHDA- 2020/04/02 06:01
PMCR- 2020/01/01
CRDT- 2020/04/02 06:00
PHST- 2019/05/08 00:00 [received]
PHST- 2020/01/19 00:00 [accepted]
PHST- 2020/04/02 06:00 [entrez]
PHST- 2020/04/02 06:00 [pubmed]
PHST- 2020/04/02 06:01 [medline]
PHST- 2020/01/01 00:00 [pmc-release]
AID - jcav11p3318 [pii]
AID - 10.7150/jca.36500 [doi]
PST - epublish
SO  - J Cancer. 2020 Mar 5;11(11):3318-3326. doi: 10.7150/jca.36500. eCollection 2020.