PMID- 32232954
OWN - NLM
STAT- MEDLINE
DCOM- 20211022
LR  - 20220402
IS  - 1751-7893 (Electronic)
IS  - 1751-7885 (Print)
IS  - 1751-7885 (Linking)
VI  - 15
IP  - 2
DP  - 2021 Apr
TI  - Depression, family interaction and family intervention in adolescents at 
      clinical-high risk for psychosis.
PG  - 360-366
LID - 10.1111/eip.12954 [doi]
AB  - AIM: The relationship between family behaviour and depression in adolescents at 
      clinical high risk (CHR) for psychosis remains understudied despite high rates of 
      depression in this population. This study examines the relationship between 
      family problem-solving behaviours and depression in CHR adolescents and the 
      impact of family interventions targeting subthreshold symptoms of psychosis on 
      reducing symptoms of depression over 2-years. METHODS: Participants were a subset 
      of the North American Prodrome Longitudinal Study who were randomized to 6-months 
      of family focused therapy for individuals at CHR or family psychoeducational 
      treatment. We evaluated the relationship between communication during family 
      conflict discussion and adolescents' symptoms of depression before treatment. At 
      follow-up assessments the family treatment groups were compared on depression. 
      Finally, we compared those in family treatment with matched controls. RESULTS: 
      Adolescents' constructive communication was associated with less severe symptoms 
      of depression before treatment. Symptoms of depression improved for adolescents 
      in both family treatment groups. However, there were no significant group by 
      treatment interactions. When adolescents who participated in either type of 
      family intervention were compared to CHR adolescent controls, symptoms of 
      depression improved for adolescents in treatment and control groups, but there 
      were no significant time by treatment interactions. CONCLUSIONS: The 
      communication skills of CHR adolescents are related to both depression and their 
      parents' communication skills pre-treatment. However, reductions in depression 
      over the course of the treatment trial cannot be attributed to family treatment. 
      It is imperative to incorporate interventions that directly target depression 
      into future family treatment studies.
CI  - (c) 2020 John Wiley & Sons Australia, Ltd.
FAU - Rinne, Gabrielle R
AU  - Rinne GR
AUID- ORCID: 0000-0001-6433-3988
AD  - Department of Psychology, Yale University, New Haven, Connecticut, USA.
FAU - O'Brien, Mary P
AU  - O'Brien MP
AD  - Department of Psychology, Yale University, New Haven, Connecticut, USA.
FAU - Miklowitz, David J
AU  - Miklowitz DJ
AD  - Semel Institute, University of California, Los Angeles, California, USA.
FAU - Addington, Jean M
AU  - Addington JM
AD  - Department of Psychiatry, University of Calgary, Calgary, Canada.
FAU - Cannon, Tyrone D
AU  - Cannon TD
AD  - Department of Psychology, Yale University, New Haven, Connecticut, USA.
AD  - Department of Psychiatry, Yale University, New Haven, Connecticut, USA.
LA  - eng
GR  - UL1 TR001863/TR/NCATS NIH HHS/United States
GR  - RC1 MH088546/MH/NIMH NIH HHS/United States
GR  - R21 MH097007/MH/NIMH NIH HHS/United States
GR  - R01 MH123575/MH/NIMH NIH HHS/United States
GR  - R34 MH117200/MH/NIMH NIH HHS/United States
GR  - R01 MH093676/MH/NIMH NIH HHS/United States
GR  - R33 MH097007/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20200330
PL  - Australia
TA  - Early Interv Psychiatry
JT  - Early intervention in psychiatry
JID - 101320027
SB  - IM
MH  - Adolescent
MH  - *Depression/therapy
MH  - Family Therapy
MH  - Humans
MH  - Longitudinal Studies
MH  - Parents
MH  - *Psychotic Disorders/therapy
PMC - PMC8175016
MID - NIHMS1703327
OTO - NOTNLM
OT  - adolescence
OT  - clinical high risk
OT  - depression
OT  - family interaction
OT  - psychosis
COIS- CONFLICT OF INTEREST Dr. Miklowitz receives grant funding from the National 
      Institute of Mental Health (NIMH), the Danny Alberts Foundation, the Attias 
      Family Foundation, the Carl and Roberta Deutsch Foundation, the Kayne Family 
      Foundation, AIM for Mental Health, American Foundation for Suicide Prevention and 
      the Max Gray Fund; and book royalties from Guilford Press and John Wiley and 
      Sons.
EDAT- 2020/04/02 06:00
MHDA- 2022/04/03 06:00
PMCR- 2022/04/01
CRDT- 2020/04/02 06:00
PHST- 2019/09/25 00:00 [received]
PHST- 2020/01/21 00:00 [revised]
PHST- 2020/03/15 00:00 [accepted]
PHST- 2020/04/02 06:00 [pubmed]
PHST- 2022/04/03 06:00 [medline]
PHST- 2020/04/02 06:00 [entrez]
PHST- 2022/04/01 00:00 [pmc-release]
AID - 10.1111/eip.12954 [doi]
PST - ppublish
SO  - Early Interv Psychiatry. 2021 Apr;15(2):360-366. doi: 10.1111/eip.12954. Epub 
      2020 Mar 30.