PMID- 32234177 OWN - NLM STAT- MEDLINE DCOM- 20200406 LR - 20200408 IS - 0253-3758 (Print) IS - 0253-3758 (Linking) VI - 48 IP - 3 DP - 2020 Mar 24 TI - [Value of absolute quantification of myocardial perfusion by PET in detecting coronary microvascular disease in patients with non-obstructive coronaries]. PG - 205-210 LID - 10.3760/cma.j.cn112148-20191024-00652 [doi] AB - Objective: To compare the incidence of coronary microvascular disease (CMVD) between patients with non-obstructive and obstructive coronary arteries. Methods: We retrospectively analyzed 97 patients with angina pectoris, who underwent the absolute quantitative PET examination of myocardial perfusion and coronary anatomy examination within 90 days. All patients were divided into two groups: non-obstructive group (72 cases, no stenosis >/=50% in all three coronary arteries) and obstructive group (25 cases, at least one coronary stenosis >/=50%; and at least one coronary stenosis<50%). Quantitative parameters derived from PET including rest myocardial blood flow (RMBF), stress myocardial blood flow (SMBF), coronary flow reserve (CFR) and cardiovascular risk factors were compared between the two groups. CMVD was defined as CFR<2.90 and SMBF<2.17 ml.min(-1).g(-1). Results: Incidence of CMVD was significant higher in the non-obstructive coronary arteries of the obstructive group than in the non-obstructive coronary arteries of non-obstructive group (47.1% (16/34) vs. 25.5% (55/216), chi(2)=6.738, P=0.009) while incidence of CMVD was similar between non-obstructive and obstructive patients ((44% (11/25) vs. 33.3% (24/72), chi(2)=0.915, P=0.339). RMBF ((0.83+/-0.14) ml.min(-1).g(-1) vs. (0.82+/-0.17) ml.min(-1).g(-1)), SMBF ((2.13+/-0.60) ml.min(-1).g(-1) vs. (1.91+/-0.50) ml.min(-1).g(-1)) and CFR (2.59+/-0.66 vs. 2.36+/-0.47) were similar between the two groups (all P>0.05). Conclusions: CMVD can occur in non-obstructive coronary arteries in both patients with non-occlusive coronary arteries and patients with obstructive coronary arteries. Prevalence of CMVD is significantly higher in patients with obstructive coronary arteries than in patients with non-obstructive coronary arteries. The CMVD severity is similar between the two groups. FAU - Wu, P AU - Wu P AD - Department of Nuclear Medicine, First Hospital of Shanxi Medical University, Shanxi Key Laboratory of Molecular Imaging, Taiyuan 030001, China. FAU - Guo, X S AU - Guo XS AD - Department of Nuclear Medicine, First Hospital of Shanxi Medical University, Shanxi Key Laboratory of Molecular Imaging, Taiyuan 030001, China. FAU - Zhang, X AU - Zhang X AD - Province-Ministry Co-construction Collaborative Innovation Center for Molecular Imaging of Precision Medicine, Taiyuan 030001, China. FAU - Wu, Z F AU - Wu ZF AD - Department of Nuclear Medicine, First Hospital of Shanxi Medical University, Shanxi Key Laboratory of Molecular Imaging, Taiyuan 030001, China. FAU - Wang, R N AU - Wang RN AD - Province-Ministry Co-construction Collaborative Innovation Center for Molecular Imaging of Precision Medicine, Taiyuan 030001, China. FAU - Li, L AU - Li L AD - Department of Nuclear Medicine, First Hospital of Shanxi Medical University, Shanxi Key Laboratory of Molecular Imaging, Taiyuan 030001, China. FAU - Liang, M AU - Liang M AD - Department of Nuclear Medicine, First Hospital of Shanxi Medical University, Shanxi Key Laboratory of Molecular Imaging, Taiyuan 030001, China. FAU - Wang, H L AU - Wang HL AD - Province-Ministry Co-construction Collaborative Innovation Center for Molecular Imaging of Precision Medicine, Taiyuan 030001, China. FAU - Yan, M AU - Yan M AD - Department of Nuclear Medicine, First Hospital of Shanxi Medical University, Shanxi Key Laboratory of Molecular Imaging, Taiyuan 030001, China. FAU - Qin, Z X AU - Qin ZX AD - Department of Nuclear Medicine, First Hospital of Shanxi Medical University, Shanxi Key Laboratory of Molecular Imaging, Taiyuan 030001, China. FAU - Cheng, P L AU - Cheng PL AD - Department of Nuclear Medicine, First Hospital of Shanxi Medical University, Shanxi Key Laboratory of Molecular Imaging, Taiyuan 030001, China. FAU - Jin, C R AU - Jin CR AD - Department of cardiology, First Hospital of Shanxi Medical University, Taiyuan 030001, China. FAU - Yang, M F AU - Yang MF AD - Department of Nuclear Medicine, Beijing Chaoyang hospital, Capital Medical University, Beijing 100043, China. FAU - Wang, Y T AU - Wang YT AD - Department of Nuclear Medicine, Third Affiliated Hospital of Soochow University (First People's Hospital of Changzhou), Changzhou 213003, China. FAU - Li, S J AU - Li SJ AD - Department of Nuclear Medicine, First Hospital of Shanxi Medical University, Shanxi Key Laboratory of Molecular Imaging, Taiyuan 030001, China. LA - chi GR - 81671724/National Natural Science Foundation of China/ GR - 201801D211004/Program for the Innovative Talents of Higher Learning Institutions and Applied Basic Research Project of Shanxi Province/ PT - Journal Article PL - China TA - Zhonghua Xin Xue Guan Bing Za Zhi JT - Zhonghua xin xue guan bing za zhi JID - 7910682 SB - IM MH - Coronary Angiography MH - *Coronary Artery Disease MH - Coronary Circulation MH - Coronary Stenosis MH - Humans MH - *Myocardial Perfusion Imaging MH - Positron-Emission Tomography MH - Retrospective Studies OTO - NOTNLM OT - Coronary artery disease OT - Coronary flow reserve OT - Microcirculation OT - Positron-emission tomography EDAT- 2020/04/03 06:00 MHDA- 2020/04/09 06:00 CRDT- 2020/04/03 06:00 PHST- 2020/04/03 06:00 [entrez] PHST- 2020/04/03 06:00 [pubmed] PHST- 2020/04/09 06:00 [medline] AID - 10.3760/cma.j.cn112148-20191024-00652 [doi] PST - ppublish SO - Zhonghua Xin Xue Guan Bing Za Zhi. 2020 Mar 24;48(3):205-210. doi: 10.3760/cma.j.cn112148-20191024-00652.