PMID- 32234435
OWN - NLM
STAT- MEDLINE
DCOM- 20210308
LR  - 20210308
IS  - 1879-0003 (Electronic)
IS  - 0141-8130 (Linking)
VI  - 155
DP  - 2020 Jul 15
TI  - A sodium alginate/feather keratin composite fiber with skin-core structure as the 
      carrier for sustained drug release.
PG  - 386-392
LID - S0141-8130(20)32811-7 [pii]
LID - 10.1016/j.ijbiomac.2020.03.224 [doi]
AB  - To alleviate the serious gastrointestinal side reaction of indomethacin (IDM), 
      sodium alginate/feather keratin (SA/FK) fiber with skin-core structure was 
      prepared via wet spinning as the carrier for sustained release of IDM. Fourier 
      translation infrared (FT-IR) spectroscopy was adopted to investigate the reaction 
      mechanism among SA, FK and IDM, and Ultraviolet-visible (UV-Vis) spectroscopy was 
      used to systematically evaluate the sustained release capacity of SA/FK fiber in 
      three simulated fluids. Scanning electron microscope (SEM) was employed to 
      observe the apparent morphology of SA/FK fiber. The results indicate that, 
      release amount of IDM exhibits an increase trend along with time; the release 
      amount of IDM reaches 80% after 12 h in colon fluid and small intestinal fluid, 
      and is less than 20% in digestive fluid. Simultaneously, FK can effectively 
      control the release of IDM, and with the increase of FK content, IDM release time 
      of the carrier fiber extends.
CI  - Copyright (c) 2020 Elsevier B.V. All rights reserved.
FAU - Gong, Xueyong
AU  - Gong X
AD  - Dalian Polytechnic University, Liaoning 116034, PR China; Shandong First Medical 
      University, Taian, 271016, PR China.
FAU - Dang, Guangyao
AU  - Dang G
AD  - Shandong First Medical University, Taian, 271016, PR China.
FAU - Guo, Jing
AU  - Guo J
AD  - Dalian Polytechnic University, Liaoning 116034, PR China; Liaoning Engineering 
      Technology Research Center of Function Fiber and Its Composites, Dalian 
      Polytechnic University, Dalian 116034, PR China. Electronic address: 
      guojing8161@163.com.
FAU - Liu, Yuanfa
AU  - Liu Y
AD  - Dalian Polytechnic University, Liaoning 116034, PR China; Liaoning Engineering 
      Technology Research Center of Function Fiber and Its Composites, Dalian 
      Polytechnic University, Dalian 116034, PR China. Electronic address: 
      Liuyf@dlpu.edu.cn.
FAU - Gong, Yumei
AU  - Gong Y
AD  - Dalian Polytechnic University, Liaoning 116034, PR China; Liaoning Engineering 
      Technology Research Center of Function Fiber and Its Composites, Dalian 
      Polytechnic University, Dalian 116034, PR China.
LA  - eng
PT  - Journal Article
DEP - 20200328
PL  - Netherlands
TA  - Int J Biol Macromol
JT  - International journal of biological macromolecules
JID - 7909578
RN  - 0 (Alginates)
RN  - 0 (Delayed-Action Preparations)
RN  - 0 (Drug Carriers)
RN  - 68238-35-7 (Keratins)
RN  - XXE1CET956 (Indomethacin)
SB  - IM
MH  - Alginates/*chemistry
MH  - Animals
MH  - Delayed-Action Preparations
MH  - Drug Carriers/*chemistry
MH  - Drug Liberation
MH  - Ducks
MH  - Feathers/chemistry
MH  - Gastrointestinal Tract/drug effects
MH  - Indomethacin/adverse effects/chemistry/*pharmacokinetics
MH  - Keratins/*chemistry
MH  - Spectroscopy, Fourier Transform Infrared
OTO - NOTNLM
OT  - Feather keratin
OT  - Indomethacin
OT  - Sodium alginate
OT  - Sustained drug release
EDAT- 2020/04/03 06:00
MHDA- 2021/03/09 06:00
CRDT- 2020/04/03 06:00
PHST- 2019/12/23 00:00 [received]
PHST- 2020/03/10 00:00 [revised]
PHST- 2020/03/25 00:00 [accepted]
PHST- 2020/04/03 06:00 [pubmed]
PHST- 2021/03/09 06:00 [medline]
PHST- 2020/04/03 06:00 [entrez]
AID - S0141-8130(20)32811-7 [pii]
AID - 10.1016/j.ijbiomac.2020.03.224 [doi]
PST - ppublish
SO  - Int J Biol Macromol. 2020 Jul 15;155:386-392. doi: 
      10.1016/j.ijbiomac.2020.03.224. Epub 2020 Mar 28.