PMID- 32234510
OWN - NLM
STAT- MEDLINE
DCOM- 20210219
LR  - 20210219
IS  - 1873-6351 (Electronic)
IS  - 0278-6915 (Linking)
VI  - 140
DP  - 2020 Jun
TI  - Multigenerational and transgenerational effects of 
      2,3,7,8-tetrachlorodibenzo-p-dioxin exposure on ovarian reserve and follicular 
      development through AMH/AMHR2 pathway in adult female rats.
PG  - 111309
LID - S0278-6915(20)30197-6 [pii]
LID - 10.1016/j.fct.2020.111309 [doi]
AB  - 2,3,7,8-Tetrachlorobenzo-p-dioxin (TCDD), one of the key endocrine disruptors, 
      has been shown to cause reproductive and developmental disorders. Our previous 
      studies have primarily focused on TCDD induced impairment of ovarian follicular 
      development in female F1 rats. It is unknown whether TCDD exposure will interfere 
      with follicular development by altering mRNA expression of anti-Mullerian hormone 
      (AMH) and AMH receptor type II (AMHR2) in the ovary. In the present study, 
      pregnant Sprague Dawley rats were treated with TCDD (100 or 500 ng/kg body 
      weight) dissolved in a corn oil vehicle by gavage from gavage from gestational 
      days (GD) 8-14, while the control group received solely corn oil. The F1 rats 
      were mated with unexposed males for the F2 generation, while another portion of 
      the female offspring (F2) were mated for the F3 generation. Serum AMH levels and 
      ovarian AMH/AMHR2 mRNA expression in the adult female offspring (F1, F2 and F3 
      generations) were measured. Follicle count and granulosa cell apoptosis were 
      evaluated in the F2 and F3 generations. The results showed that in the F2 
      generation, TCDD exposure affected the number of primordial follicles, secondary 
      follicles, and corpora lutea. It also increased serum AMH concentration and the 
      apoptosis rate of granulosa cells. These results might be associated with the 
      upregulation of AMH/AMHR2 mRNA expression in the ovary. In conclusion, TCDD 
      exposure reduced the ovarian reserve in rats and inhibited follicular development 
      in adult female offspring, an effect that persisted for multiple generations. The 
      altered AMH and AMHR2 mRNA expression may contribute to the observed adverse 
      effects.
CI  - Copyright (c) 2020 Elsevier Ltd. All rights reserved.
FAU - Yu, Kailun
AU  - Yu K
AD  - Department of Nutrition and Food Hygiene, Public Health College of Zhengzhou 
      University, Zhengzhou, 450001, China.
FAU - Zhang, Xiuli
AU  - Zhang X
AD  - Department of Surgery, The First Affiliated Hospital of Zhengzhou University, 
      Zhengzhou, 450052, China.
FAU - Tan, Xuemei
AU  - Tan X
AD  - Department of Nutrition and Food Hygiene, Public Health College of Zhengzhou 
      University, Zhengzhou, 450001, China.
FAU - Ji, Mengmeng
AU  - Ji M
AD  - Department of Epidemiology, Public Health College of Southeast University, 
      Nanjing, 210009, China.
FAU - Chen, Yao
AU  - Chen Y
AD  - Department of Nutrition and Food Hygiene, Public Health College of Zhengzhou 
      University, Zhengzhou, 450001, China.
FAU - Wan, Zhongxiao
AU  - Wan Z
AD  - Department of Nutrition and Food Hygiene, Public Health College of Zhengzhou 
      University, Zhengzhou, 450001, China. Electronic address: zhxwan@suda.edu.cn.
FAU - Yu, Zengli
AU  - Yu Z
AD  - Department of Nutrition and Food Hygiene, Public Health College of Zhengzhou 
      University, Zhengzhou, 450001, China. Electronic address: zly@zzu.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20200329
PL  - England
TA  - Food Chem Toxicol
JT  - Food and chemical toxicology : an international journal published for the British 
      Industrial Biological Research Association
JID - 8207483
RN  - 0 (Polychlorinated Dibenzodioxins)
RN  - 0 (RNA, Messenger)
RN  - 0 (Receptors, Peptide)
RN  - 0 (Receptors, Transforming Growth Factor beta)
RN  - 0 (anti-Mullerian hormone receptor)
RN  - 80497-65-0 (Anti-Mullerian Hormone)
SB  - IM
MH  - Animals
MH  - Anti-Mullerian Hormone/genetics/*metabolism
MH  - Female
MH  - Male
MH  - Ovarian Follicle/*drug effects/growth & development
MH  - Ovarian Reserve/*drug effects
MH  - Polychlorinated Dibenzodioxins/*toxicity
MH  - Pregnancy
MH  - RNA, Messenger/genetics
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptors, Peptide/genetics/*metabolism
MH  - Receptors, Transforming Growth Factor beta/genetics/*metabolism
OTO - NOTNLM
OT  - 2,3,7,8-Tetrachlorodibenzo-p-dioxin
OT  - Anti-Mullerian hormone
OT  - Multigenerational
OT  - Ovarian impairment
OT  - Transgenerational
COIS- Declaration of competing interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2020/04/03 06:00
MHDA- 2021/02/20 06:00
CRDT- 2020/04/03 06:00
PHST- 2019/09/11 00:00 [received]
PHST- 2020/03/20 00:00 [revised]
PHST- 2020/03/25 00:00 [accepted]
PHST- 2020/04/03 06:00 [pubmed]
PHST- 2021/02/20 06:00 [medline]
PHST- 2020/04/03 06:00 [entrez]
AID - S0278-6915(20)30197-6 [pii]
AID - 10.1016/j.fct.2020.111309 [doi]
PST - ppublish
SO  - Food Chem Toxicol. 2020 Jun;140:111309. doi: 10.1016/j.fct.2020.111309. Epub 2020 
      Mar 29.