PMID- 32234890
OWN - NLM
STAT- MEDLINE
DCOM- 20200410
LR  - 20200410
IS  - 1791-7530 (Electronic)
IS  - 0250-7005 (Linking)
VI  - 40
IP  - 4
DP  - 2020 Apr
TI  - Association Between MMP8 Gene Polymorphisms and Laryngeal Squamous Cell 
      Carcinoma.
PG  - 2003-2009
LID - 10.21873/anticanres.14156 [doi]
AB  - BACKGROUND/AIM: Matrix metalloproteinases (MMPs) are a family of proteins which 
      are involved in breakdown of the extracellular matrix in embryonic development, 
      tissue remodeling and in some diseases. MMP8 has both cancer-promoting and 
      anticancer properties. However, the contribution of MMP8 to laryngeal squamous 
      cell carcinoma (LSCC) has not been elucidated. In this study we aimed to test the 
      contribution of two MMP8 polymorphisms, located in the gene promoter region, to 
      the development of LSCC. MATERIALS AND METHODS: This case-control study involved 
      569 DNA samples which were genotyped for two single nucleotide polymorphisms 
      using real-time polymerase chain reaction method. Statistical analysis was 
      performed with SPSS Statistics 20 software. RESULTS: Regression analysis adjusted 
      by age showed that for MMP8 rs11225395 each minor A allele copy significantly 
      reduced the odds for LSCC development (odds ratio=0.49, 95% confidence 
      intervaI=0.04-2.19, p=0.048). MMP8 rs11225395 AA genotype was associated with 
      smaller laryngeal tumour size (p=0.023). Smoking habit also correlated with 
      laryngeal tumor size. CONCLUSION: MMP8 rs11225395 and smoking habits have a 
      prominent interface with LSCC tumour size.
CI  - Copyright(c) 2020, International Institute of Anticancer Research (Dr. George J. 
      Delinasios), All rights reserved.
FAU - Insodaite, Ruta
AU  - Insodaite R
AD  - Institute of Biology Systems and Genetic Research, Veterinary Academy, Lithuanian 
      University of Health Sciences, Kaunas, Lithuania ruta.insodaite@lsmuni.lt.
FAU - Liutkevicius, Vykintas
AU  - Liutkevicius V
AD  - Department of Otorhinolaryngology, Lithuanian University of Health Sciences, 
      Kaunas, Lithuania.
FAU - Uloza, Virgilijus
AU  - Uloza V
AD  - Department of Otorhinolaryngology, Lithuanian University of Health Sciences, 
      Kaunas, Lithuania.
FAU - Solovejute, Rosita
AU  - Solovejute R
AD  - Lithuanian University of Health Sciences, Kaunas, Lithuania.
FAU - Smalinskiene, Alina
AU  - Smalinskiene A
AD  - Institute of Biology Systems and Genetic Research, Veterinary Academy, Lithuanian 
      University of Health Sciences, Kaunas, Lithuania.
AD  - Laboratory of Molecular Cardiology, Institute of Cardiology, Medical Academy, 
      Lithuanian University of Health Sciences, Kaunas, Lithuania.
LA  - eng
PT  - Journal Article
PL  - Greece
TA  - Anticancer Res
JT  - Anticancer research
JID - 8102988
RN  - EC 3.4.24.34 (MMP8 protein, human)
RN  - EC 3.4.24.34 (Matrix Metalloproteinase 8)
SB  - IM
MH  - Alleles
MH  - Carcinoma, Squamous Cell/*genetics/pathology
MH  - Female
MH  - Genetic Association Studies
MH  - *Genetic Predisposition to Disease
MH  - Genotype
MH  - Humans
MH  - Laryngeal Neoplasms/*genetics/pathology
MH  - Male
MH  - Matrix Metalloproteinase 8/*genetics
MH  - Middle Aged
MH  - Polymorphism, Single Nucleotide
OTO - NOTNLM
OT  - Laryngeal squamous cell carcinoma
OT  - MMR8
OT  - matrix metalloproteinase 8
OT  - matrix metalloproteinases
OT  - rs11225395
OT  - rs2155052
OT  - single nucleotide polymorphism
EDAT- 2020/04/03 06:00
MHDA- 2020/04/11 06:00
CRDT- 2020/04/03 06:00
PHST- 2020/02/11 00:00 [received]
PHST- 2020/02/21 00:00 [revised]
PHST- 2020/02/25 00:00 [accepted]
PHST- 2020/04/03 06:00 [entrez]
PHST- 2020/04/03 06:00 [pubmed]
PHST- 2020/04/11 06:00 [medline]
AID - 40/4/2003 [pii]
AID - 10.21873/anticanres.14156 [doi]
PST - ppublish
SO  - Anticancer Res. 2020 Apr;40(4):2003-2009. doi: 10.21873/anticanres.14156.