PMID- 32234895
OWN - NLM
STAT- MEDLINE
DCOM- 20200410
LR  - 20200410
IS  - 1791-7530 (Electronic)
IS  - 0250-7005 (Linking)
VI  - 40
IP  - 4
DP  - 2020 Apr
TI  - B-cell Receptor Recombinations in Lung Adenocarcinoma Exome Files Correlate With 
      a Higher Overall Survival Rate.
PG  - 2043-2051
LID - 10.21873/anticanres.14161 [doi]
AB  - BACKGROUND/AIM: While there has been a rapid development in genomic data mining 
      approaches for T-cell receptor recombinations (TcR), less emphasis has been 
      placed on B-cell receptor (BcR) recombinations. MATERIALS AND METHODS: We 
      obtained lung cancer exome files from the cancer genome atlas (TCGA) and mined 
      the files for TcR and BcR recombination reads. RESULTS: There was a robust 
      detection of BcR light chain recombination reads in lung adenocarcinoma 
      (TCGA-LUAD) samples, and there was a correlation between the detection of light 
      chain recombination reads and a more favorable outcome. This result was supported 
      by analyses of the expression of B-cell markers as indicated by LUAD RNASeq 
      files. CONCLUSION: BcR and TcR recombination reads recovered from LUAD WXS files, 
      either alone or in combination with the human leukocyte antigen (HLA) type, are 
      likely to have prognostic value.
CI  - Copyright(c) 2020, International Institute of Anticancer Research (Dr. George J. 
      Delinasios), All rights reserved.
FAU - Tu, Yaping N
AU  - Tu YN
AD  - Department of Molecular Medicine, Morsani College of Medicine, University of 
      South Florida, Tampa, FL, U.S.A.
FAU - Tong, Wei Lue
AU  - Tong WL
AD  - Department of Molecular Medicine, Morsani College of Medicine, University of 
      South Florida, Tampa, FL, U.S.A.
FAU - Callahan, Blake M
AU  - Callahan BM
AD  - Department of Molecular Medicine, Morsani College of Medicine, University of 
      South Florida, Tampa, FL, U.S.A.
FAU - Chobrutskiy, Boris I
AU  - Chobrutskiy BI
AD  - Department of Molecular Medicine, Morsani College of Medicine, University of 
      South Florida, Tampa, FL, U.S.A.
FAU - Blanck, George
AU  - Blanck G
AD  - Department of Molecular Medicine, Morsani College of Medicine, University of 
      South Florida, Tampa, FL, U.S.A. gblanck@usf.edu.
AD  - Department of Immunology, H. Lee Moffitt Cancer Center and Research Institute, 
      Tampa, FL, U.S.A.
LA  - eng
PT  - Journal Article
PL  - Greece
TA  - Anticancer Res
JT  - Anticancer research
JID - 8102988
RN  - 0 (HLA Antigens)
RN  - 0 (Receptors, Antigen, T-Cell)
RN  - 0 (Receptors, Antigen, T-Cell, alpha-beta)
SB  - IM
MH  - Adenocarcinoma of Lung/*genetics/immunology/pathology
MH  - Disease-Free Survival
MH  - Exome/genetics
MH  - Female
MH  - HLA Antigens/genetics/immunology
MH  - Humans
MH  - Kaplan-Meier Estimate
MH  - Male
MH  - Prognosis
MH  - RNA Interference
MH  - Receptors, Antigen, T-Cell/*genetics/immunology
MH  - Receptors, Antigen, T-Cell, alpha-beta/*genetics/immunology
MH  - Recombination, Genetic/*genetics/immunology
OTO - NOTNLM
OT  - BcR gene recombinations
OT  - CD19
OT  - CD20
OT  - CD79 B-cell markers
OT  - IGK
OT  - lung adenocarcinoma
OT  - survival rates
OT  - tumor specimen exomes
EDAT- 2020/04/03 06:00
MHDA- 2020/04/11 06:00
CRDT- 2020/04/03 06:00
PHST- 2020/01/27 00:00 [received]
PHST- 2020/02/24 00:00 [revised]
PHST- 2020/03/04 00:00 [accepted]
PHST- 2020/04/03 06:00 [entrez]
PHST- 2020/04/03 06:00 [pubmed]
PHST- 2020/04/11 06:00 [medline]
AID - 40/4/2043 [pii]
AID - 10.21873/anticanres.14161 [doi]
PST - ppublish
SO  - Anticancer Res. 2020 Apr;40(4):2043-2051. doi: 10.21873/anticanres.14161.