PMID- 32237208
OWN - NLM
STAT- MEDLINE
DCOM- 20211022
LR  - 20220716
IS  - 1751-7893 (Electronic)
IS  - 1751-7885 (Print)
IS  - 1751-7885 (Linking)
VI  - 15
IP  - 3
DP  - 2021 Jun
TI  - Computer-aided learning for managing stress: A feasibility trial with clinical 
      high risk adolescents and young adults.
PG  - 471-479
LID - 10.1111/eip.12958 [doi]
AB  - AIM: The peak onset of psychotic disorders occurs during adolescence and early 
      adulthood, yet treatments for youth at clinical high risk (CHR) for psychosis are 
      generally designed for adults. CHR youth, despite poor academic and social 
      engagement, spend hours each day playing complicated videogames. The aim of this 
      study was to test the feasibility of integrating biofeedback and cooperative 
      videogame play within family therapy as a means of engaging and enhancing this 
      population's resilience. METHODS: We conducted a feasibility trial of an 
      innovative 12-week family therapy for CHR ages 12-30 (clinicaltrials.gov 
      NCT02531243). We report feasibility outcomes and preliminary effect sizes for 
      pre-post changes and youth-parent differences. RESULTS: Of 88 individuals 
      referred to the centre who met age and CHR criteria, 11 (13%) youth-parent pairs 
      met full criteria and engaged in treatment. Ten (91%) completed at least six 
      sessions. Youth found CALMS initially credible, but parents tended to find it 
      more credible and to be more satisfied over time. Surprisingly, parents reported 
      a better game experience than youth. As a group, youth and parent participants 
      reported experiencing reduced stress and perceiving each other as less critical 
      by the end of treatment. Youth were rated as having significantly improved 
      social, but not role or global functioning by the end of treatment. CONCLUSIONS: 
      Multiuser videogames may have a role to play in engaging youth at risk for 
      psychosis in therapy and reducing stress and familial risk factors. A number of 
      key developments are needed to enhance the appeal, effectiveness and practicality 
      of this approach.
CI  - (c) 2020 John Wiley & Sons Australia, Ltd.
FAU - Woodberry, Kristen A
AU  - Woodberry KA
AUID- ORCID: 0000-0001-8282-1803
AD  - Public Psychiatry Division, Beth Israel Deaconess Medical Center, Boston, 
      Massachusetts, USA.
AD  - Psychiatry Department, Harvard Medical School, Boston, Massachusetts, USA.
AD  - Psychiatry Department, Maine Medical Center, Portland, Maine, USA.
FAU - Chokran, Cole
AU  - Chokran C
AD  - Public Psychiatry Division, Beth Israel Deaconess Medical Center, Boston, 
      Massachusetts, USA.
FAU - Johnson, Kelsey A
AU  - Johnson KA
AD  - Public Psychiatry Division, Beth Israel Deaconess Medical Center, Boston, 
      Massachusetts, USA.
FAU - Nuechterlein, Keith H
AU  - Nuechterlein KH
AD  - Departments of Psychiatry and Psychology, University of California, Los Angeles, 
      California, USA.
FAU - Miklowitz, David J
AU  - Miklowitz DJ
AD  - Departments of Psychiatry and Psychology, University of California, Los Angeles, 
      California, USA.
AD  - Department of Psychiatry and Biobehavioral Sciences, University of California, 
      Los Angeles, California, USA.
FAU - Faraone, Stephen V
AU  - Faraone SV
AD  - Departments of Psychiatry and of Neuroscience and Physiology, SUNY Upstate 
      Medical University, Syracuse, New York, USA.
FAU - Seidman, Larry J
AU  - Seidman LJ
AD  - Public Psychiatry Division, Beth Israel Deaconess Medical Center, Boston, 
      Massachusetts, USA.
LA  - eng
SI  - ClinicalTrials.gov/NCT02531243
GR  - K23 MH102358/MH/NIMH NIH HHS/United States
GR  - R01 MH123575/MH/NIMH NIH HHS/United States
GR  - R34 MH117200/MH/NIMH NIH HHS/United States
GR  - R01 MH093676/MH/NIMH NIH HHS/United States
GR  - R33 MH097007/MH/NIMH NIH HHS/United States
PT  - Clinical Trial
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20200401
PL  - Australia
TA  - Early Interv Psychiatry
JT  - Early intervention in psychiatry
JID - 101320027
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Child
MH  - Computers
MH  - Family Therapy
MH  - Feasibility Studies
MH  - Humans
MH  - Parents
MH  - *Psychotic Disorders/therapy
MH  - Young Adult
PMC - PMC8175018
MID - NIHMS1703322
OTO - NOTNLM
OT  - biofeedback
OT  - family therapy
OT  - multiuser
OT  - psychosis
OT  - stress
OT  - videogame
COIS- CONFLICT OF INTEREST The authors have no conflicts of interest to declare. The 
      game technology is owned by Boston Children's Hospital.
EDAT- 2020/04/03 06:00
MHDA- 2021/10/26 06:00
PMCR- 2022/06/01
CRDT- 2020/04/03 06:00
PHST- 2020/03/03 00:00 [revised]
PHST- 2019/12/03 00:00 [received]
PHST- 2020/03/15 00:00 [accepted]
PHST- 2020/04/03 06:00 [pubmed]
PHST- 2021/10/26 06:00 [medline]
PHST- 2020/04/03 06:00 [entrez]
PHST- 2022/06/01 00:00 [pmc-release]
AID - 10.1111/eip.12958 [doi]
PST - ppublish
SO  - Early Interv Psychiatry. 2021 Jun;15(3):471-479. doi: 10.1111/eip.12958. Epub 
      2020 Apr 1.