PMID- 32237405
OWN - NLM
STAT- MEDLINE
DCOM- 20200625
LR  - 20200625
IS  - 1001-5302 (Print)
IS  - 1001-5302 (Linking)
VI  - 45
IP  - 1
DP  - 2020 Jan
TI  - [Molecular regulative mechanisms of NLRP3 inflammasome activation in diabetic 
      nephropathy and interventional effects of Chinese herbal medicine].
PG  - 7-13
LID - 10.19540/j.cnki.cjcmm.20190618.402 [doi]
AB  - The progression of renal damage in diabetic nephropathy(DN)is closely related to 
      Nod-like receptor protein3(NLRP3)inflammasome activation. The characteristics of 
      NLRP3 inflammasome activation include the changed expression and combination 
      levels of NLRP3, apoptosis-associated speck-like protein(ASC)and pro-caspase-1, 
      the increased expression levels of caspase-1, interleukin(IL)-1beta and IL-18 and 
      the excessive release levels of the relative inflammatory mediators. Its 
      molecular regulative mechanisms involve the activation of multiple signaling 
      pathways including reactive oxygen species(ROS)/thioredoxin-interacting 
      protein(TXNIP)pathway, nuclear factor(NF)-kappaB pathway, nuclear factor 
      erythroid-related factor 2(Nrf2)pathway, long non-coding RNA(lncRNA)pathway and 
      mitogen-activated protein kinases(MAPKs)pathway. In addition, more importantly, 
      never in mitosis aspergillus-related kinase 7(Nek7), as a kinase regulator, could 
      target-combine with NLRP3 at upstream to activate NLRP3 inflammasome. Some 
      extracts of Chinese herbal medicines(CHMs)such as quercetin, curcumin, 
      cepharanthine, piperine and salidroside, as well as Chinese herbal compound 
      prescriptions such as Wumei Pills both could treat NLRP3 inflammasome to 
      ameliorate inflammatory renal damage in DN. Therefore, accurately clarifying the 
      targets of anti-inflammatory CHMs and Chinese herbal compound prescriptions 
      delaying DN progression by targeting the molecular regulative mechanisms of NLRP3 
      inflammasome activation will be one of the development directions in the future.
FAU - Wang, Wen-Wen
AU  - Wang WW
AD  - Department of Traditional Chinese Medicine, Nanjing Drum Tower Hospital Clinical 
      College of Traditional Chinese and Western Medicine, Nanjing University of 
      Chinese Medicine Nanjing 210008, China Department of Nephrology,Wenzhou Hospital 
      of Integrated Traditional Chinese and Western Medicine Wenzhou 325000, China.
FAU - Han, Wen-Bei
AU  - Han WB
AD  - Department of Traditional Chinese Medicine, Nanjing Drum Tower Hospital Clinical 
      College of Traditional Chinese and Western Medicine, Nanjing University of 
      Chinese Medicine Nanjing 210008, China.
FAU - Wan, Yi-Gang
AU  - Wan YG
AD  - Department of Traditional Chinese Medicine, Nanjing Drum Tower Hospital, the 
      Affiliated Hospital of Nanjing University Medical School Nanjing 210008, China.
FAU - Tu, Yue
AU  - Tu Y
AD  - Department of Traditional Chinese Medicine Health Preservation, Acupuncture and 
      Moxibustion and Massage College.Health Preservation and Rehabilitation College, 
      Nanjing University of Chinese Medicine Nanjing 210023, China.
FAU - Liu, Bu-Hui
AU  - Liu BH
AD  - Department of Nephrology, the Affiliated Hospital of Nanjing University of 
      Chinese Medicine Nanjing 210029, China.
FAU - Liu, Ying-Lu
AU  - Liu YL
AD  - Department of Traditional Chinese Medicine, Nanjing Drum Tower Hospital Clinical 
      College of Traditional Chinese and Western Medicine, Nanjing University of 
      Chinese Medicine Nanjing 210008, China.
FAU - Wu, Wei
AU  - Wu W
AD  - Department of Traditional Chinese Medicine, Nanjing Drum Tower Hospital, the 
      Affiliated Hospital of Nanjing University Medical School Nanjing 210008, China.
FAU - Yee, Hong-Yun
AU  - Yee HY
AD  - Department of Traditional Chinese Medicine, Nanjing Drum Tower Hospital Clinical 
      College of Traditional Chinese and Western Medicine, Nanjing University of 
      Chinese Medicine Nanjing 210008, China.
FAU - Fang, Qi-Jun
AU  - Fang QJ
AD  - Department of Traditional Chinese Medicine, Nanjing Drum Tower Hospital, the 
      Affiliated Hospital of Nanjing University Medical School Nanjing 210008, China.
FAU - Yao, Jian
AU  - Yao J
AD  - Division of Molecular Signaling, Department of Advanced Biomedical Research, 
      Interdisciplinary Graduate School of Medicine and Engineering, University of 
      Yamanashi Yamanashi 409-3898, Japan.
LA  - chi
PT  - Journal Article
PL  - China
TA  - Zhongguo Zhong Yao Za Zhi
JT  - Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese 
      materia medica
JID - 8913656
RN  - 0 (Drugs, Chinese Herbal)
RN  - 0 (IL1B protein, human)
RN  - 0 (Inflammasomes)
RN  - 0 (Interleukin-18)
RN  - 0 (Interleukin-1beta)
RN  - 0 (NLR Family, Pyrin Domain-Containing 3 Protein)
RN  - 0 (NLRP3 protein, human)
RN  - EC 2.7.11.1 (NEK7 protein, human)
RN  - EC 2.7.11.1 (NIMA-Related Kinases)
RN  - EC 3.4.22.36 (Caspase 1)
SB  - IM
MH  - Caspase 1/immunology
MH  - Diabetes Mellitus/*drug therapy
MH  - Diabetic Nephropathies/*drug therapy/*immunology
MH  - Drugs, Chinese Herbal/*therapeutic use
MH  - Humans
MH  - Inflammasomes/*immunology
MH  - Interleukin-18/immunology
MH  - Interleukin-1beta/immunology
MH  - NIMA-Related Kinases
MH  - NLR Family, Pyrin Domain-Containing 3 Protein/*immunology
OTO - NOTNLM
OT  - Chinese herbal medicines
OT  - NLRP3 inflammasome
OT  - diabetic nephropathy
OT  - molecular mechanism
OT  - signaling pathway
EDAT- 2020/04/03 06:00
MHDA- 2020/06/26 06:00
CRDT- 2020/04/03 06:00
PHST- 2020/04/03 06:00 [entrez]
PHST- 2020/04/03 06:00 [pubmed]
PHST- 2020/06/26 06:00 [medline]
AID - 10.19540/j.cnki.cjcmm.20190618.402 [doi]
PST - ppublish
SO  - Zhongguo Zhong Yao Za Zhi. 2020 Jan;45(1):7-13. doi: 
      10.19540/j.cnki.cjcmm.20190618.402.