PMID- 32239860
OWN - NLM
STAT- MEDLINE
DCOM- 20200414
LR  - 20200414
IS  - 1000-6834 (Print)
IS  - 1000-6834 (Linking)
VI  - 35
IP  - 6
DP  - 2019 Nov
TI  - [Effects of Salvia przewalskii Maxim. on high-altitude pulmonary hypertension in 
      rats and its mechanism].
PG  - 533-536
LID - 10.12047/j.cjap.5854.2019.117 [doi]
AB  - OBJECTIVE: To investigate the interventive effects of Salvia przewalskii 
      Maxim.(SPM)on high-altitude pulmonary hypertension(HAPH)in rats and possible 
      mechanism. METHODS: The male SD rats were randomly divided into the control 
      group, the hypoxia group and SPM(0.5 g/kg,1 g/kg and 2 g/kg) group. There were 14 
      rats in each group. The rats in control group were feed in Xining(with an 
      altitude about 2 260 m), and the other group rats were all feed in Maduo county 
      people's hospital(with an altitude about 4 260 m). The rats in SPM groups were 
      treated with SPM at the doses of 0.5 g/kg,1 g/kg and 2 g/kg by gavage 
      respectively (100 g/ml). The rats in control and the hypoxia groups were received 
      equal volume of distilled water, once a day. After 4 weeks, the mean pulmonary 
      artery pressure (mPAP) of rats was measured and the same part of lung tissue of 
      each rat was collected and stored in liquid nitrogen. Then the relative mRNA 
      expression levels of the proliferation cell nuclear antigen(PCNA), the cell cycle 
      dependent kinase 4(CDK4), CyclinD1, RhoA, ROCK1, ROCK2 in lung tissues of each 
      group rats were all tested by RT-PCR. RESULTS: Compared with the control group, 
      the mPAP and the relative mRNA expression levels of PCNA, CDK4, CyclinD1, RhoA, 
      ROCK1 and ROCK2 were increased significantly in the hypoxia group(P＜0.01). 
      Compared with the hypoxia group, the mPAP and the relative mRNA expression levels 
      of PCNA, CDK4, CyclinD1, RhoA, ROCK1 and ROCK2 in the lung tissues of the SPM 
      group rats were all decreased significantly(P＜ 0.05 or P＜0.01). CONCLUSION: SPM 
      can prevent the HAPH in rats, and the mechanisms may be related to the inhibition 
      of the excessive proliferation of smooth muscle cells in pulmonary artery and the 
      excessive activation of the RhoA/Rho kinase(ROCK) signaling pathway.
FAU - Wang, Ya-Feng
AU  - Wang YF
AD  - PIVAS of QingHai Provincial People's Hospital, Xining 810007, China.
FAU - Wang, Ai-Xia
AU  - Wang AX
AD  - PIVAS of QingHai Provincial People's Hospital, Xining 810007, China.
FAU - Wang, Sheng-Biao
AU  - Wang SB
AD  - PIVAS of QingHai Provincial People's Hospital, Xining 810007, China.
FAU - Duo, De-Long
AU  - Duo DL
AD  - PIVAS of QingHai Provincial People's Hospital, Xining 810007, China.
FAU - Li, Qian
AU  - Li Q
AD  - PIVAS of QingHai Provincial People's Hospital, Xining 810007, China.
FAU - Yan, Ying-Jun
AU  - Yan YJ
AD  - PIVAS of QingHai Provincial People's Hospital, Xining 810007, China.
LA  - chi
PT  - Journal Article
PL  - China
TA  - Zhongguo Ying Yong Sheng Li Xue Za Zhi
JT  - Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = 
      Chinese journal of applied physiology
JID - 9426407
RN  - 0 (Drugs, Chinese Herbal)
SB  - IM
MH  - Altitude Sickness/*drug therapy
MH  - Animals
MH  - Drugs, Chinese Herbal/*pharmacology
MH  - Hypertension, Pulmonary/*drug therapy
MH  - Hypoxia/*drug therapy
MH  - Male
MH  - Pulmonary Artery
MH  - Random Allocation
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Salvia/*chemistry
EDAT- 2020/04/03 06:00
MHDA- 2020/04/15 06:00
CRDT- 2020/04/03 06:00
PHST- 2020/04/03 06:00 [entrez]
PHST- 2020/04/03 06:00 [pubmed]
PHST- 2020/04/15 06:00 [medline]
AID - 10.12047/j.cjap.5854.2019.117 [doi]
PST - ppublish
SO  - Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2019 Nov;35(6):533-536. doi: 
      10.12047/j.cjap.5854.2019.117.