PMID- 32240433
OWN - NLM
STAT- MEDLINE
DCOM- 20210514
LR  - 20210514
IS  - 1434-9949 (Electronic)
IS  - 0770-3198 (Linking)
VI  - 39
IP  - 10
DP  - 2020 Oct
TI  - Patients with psoriatic arthritis have higher levels of FeNO than those with only 
      psoriasis, which may reflect a higher prevalence of a subclinical respiratory 
      involvement.
PG  - 2981-2988
LID - 10.1007/s10067-020-05050-2 [doi]
AB  - BACKGROUND: Psoriatic arthritis (PsA) patients are often affected by numerous 
      comorbidities. However, contrasting results have been reported with regard to the 
      respiratory involvement in PsA patients. The aim of this study was to evaluate 
      the presence of subclinical airway inflammation in non-smoking PsA patients 
      compared to patients with only psoriasis using the fraction of exhaled nitric 
      oxide (FeNO) as an indirect marker of airway inflammation. METHODS: The study 
      included 164 non-smoking psoriatic patients (Psoriasis Area of Severity Index or 
      PASI score > 10): 82 with and 82 without PsA, who underwent FeNO tests at 
      different flow rates (30, 50, 100, 200 mL/s). PsA patients were evaluated with 
      Disease Activity in PSoriatic Arthritis Score (DAPSA). Both study groups were 
      compared in terms of FeNO values and its association with the PASI score. The 
      correlations between the variables were evaluated by means of Pearson's 
      coefficient. RESULTS: Patient with PsA had higher levels of FeNO than those with 
      psoriasis but without arthritis (at 30 mL/s, 71.09 +/- 18.40 ppb vs 
      66.88 +/- 19.12 ppb (NS); at 50 mL/s, 36.61 +/- 9.30 ppb vs 30.88 +/- 9.73 ppb 
      (p < 0.001); at 100 mL/s, 19.09 +/- 4.66 ppb vs 16.63 +/- 4.90 ppb (p < 0.001); and 
      at 200 mL/s, 10.88 +/- 2.53 ppb vs 9.43 +/- 2.55 ppb (p < 0.001), respectively). PASI 
      score correlated to FeNO only in psoriatic patients without arthritis. However, 
      CASPAR index correlated with FeNO (FeNO30: r = 0.81, p < 0.001; FeNO50: r = 0.84, 
      p < 0.001; FeNO100: r = 0.71, p < 0.001; FeNO200: r = 0.58, p < 0.001). DAPSA was 
      also correlated with FeNO to all flows (FeNO30: r = 0.43, p < 0.001; FeNO50: 
      r = 0.33, p < 0.001; FeNO100: r = 0.34, p < 0.001; FeNO200: r = 0.25, p < 0.001). 
      CONCLUSIONS: PsA patients seem to have more commonly subclinical airway 
      inflammation than those with only psoriasis. Further studies are needed to 
      replicate these findings. Key Points * Fraction of exhaled nitric oxide (FeNO) is 
      a useful device to detect and monitor airway inflammation not only in asthma but 
      also in systemic inflammatory diseases such as psoriatic arthritis and psoriasis. 
      * Clinicians should be aware to check respiratory diseases in patients with 
      psoriatic arthritis.
FAU - Damiani, Giovanni
AU  - Damiani G
AD  - Clinical Dermatology, IRCCS Galeazzi Orthopedic Institute, Milan, Italy. 
      dr.giovanni.damiani@gmail.com.
AD  - Department of Biomedical, Surgical and Dental Sciences, University of Milan, 
      Milan, Italy. dr.giovanni.damiani@gmail.com.
FAU - Pacifico, Alessia
AU  - Pacifico A
AD  - Phototherapy Unit, San Gallicano Dermatological Hospital, Rome, Italy.
FAU - Rizzi, Maurizio
AU  - Rizzi M
AD  - Respiratory Unit, Center for Sleep and Respiratory Disorders, "Luigi Sacco" 
      University Hospital, Milan, Italy.
FAU - Santus, Pierachille
AU  - Santus P
AD  - Respiratory Unit, Center for Sleep and Respiratory Disorders, "Luigi Sacco" 
      University Hospital, Milan, Italy.
AD  - Department of Biomedical Sciences L. Sacco, University of Milan, Milan, Italy.
FAU - Bridgewood, Charlie
AU  - Bridgewood C
AD  - Section of Musculoskeletal Disease, Leeds Institute of Molecular Medicine, 
      University of Leeds, NIHR Leeds Musculoskeletal Biomedical Research Unit, Chapel 
      Allerton Hospital, Leeds, UK.
FAU - Bragazzi, Nicola Luigi
AU  - Bragazzi NL
AD  - Laboratory for Industrial and Applied Mathematics (LIAM), Department of 
      Mathematics and Statistics, York University, Toronto, Canada.
FAU - Adawi, Mohammed
AU  - Adawi M
AD  - Padeh and Ziv Hospitals, Azrieli Faculty of Medicine, Bar-Ilan University, Ramat 
      Gan, Israel.
FAU - Watad, Abdulla
AU  - Watad A
AD  - Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
AD  - Department of Medicine B, Sheba Medical Center, Tel Hashomer, Israel.
LA  - eng
PT  - Journal Article
DEP - 20200402
PL  - Germany
TA  - Clin Rheumatol
JT  - Clinical rheumatology
JID - 8211469
RN  - 31C4KY9ESH (Nitric Oxide)
SB  - IM
MH  - *Arthritis, Psoriatic/diagnosis/epidemiology
MH  - Exhalation
MH  - Humans
MH  - Nitric Oxide
MH  - Prevalence
MH  - *Psoriasis
OTO - NOTNLM
OT  - Airway inflammation
OT  - CASPAR
OT  - FeNO
OT  - PASI
OT  - Psoriasis
OT  - Psoriatic arthritis
EDAT- 2020/04/03 06:00
MHDA- 2021/05/15 06:00
CRDT- 2020/04/03 06:00
PHST- 2019/09/19 00:00 [received]
PHST- 2020/03/20 00:00 [accepted]
PHST- 2020/03/12 00:00 [revised]
PHST- 2020/04/03 06:00 [pubmed]
PHST- 2021/05/15 06:00 [medline]
PHST- 2020/04/03 06:00 [entrez]
AID - 10.1007/s10067-020-05050-2 [pii]
AID - 10.1007/s10067-020-05050-2 [doi]
PST - ppublish
SO  - Clin Rheumatol. 2020 Oct;39(10):2981-2988. doi: 10.1007/s10067-020-05050-2. Epub 
      2020 Apr 2.