PMID- 32240524
OWN - NLM
STAT- MEDLINE
DCOM- 20211022
LR  - 20211022
IS  - 1868-601X (Electronic)
IS  - 1868-4483 (Linking)
VI  - 12
IP  - 1
DP  - 2021 Feb
TI  - Endogenous Regulatory T Cells Promote M2 Macrophage Phenotype in Diabetic Stroke 
      as Visualized by Optical Imaging.
PG  - 136-146
LID - 10.1007/s12975-020-00808-x [doi]
AB  - Regulatory T cells (Tregs) play an immunosuppressive role in various diseases, 
      yet their function remains controversial in stroke and obscure in diabetic 
      stroke. In the present study, Tregs were found downregulated in the peripheral 
      blood of type 2 diabetes mellitus (T2DM) stroke models and patients compared with 
      controls. In ischemic stroke mice (both T2DM and wild type), endogenous Tregs 
      boosted by CD28SA increased CD206+ M2 macrophage/microglia cells, decreased 
      infarct volumes, and improved neurological recovery. Our results demonstrated the 
      potential of boosting Tregs for treating T2DM stroke. Furthermore, we utilized an 
      optical imaging probe (IRD-alphaCD206) to target M2 macrophage/microglia cells and 
      demonstrated its effect in visualizing M2 macrophage/microglia cells in vivo in 
      ischemic brain tissue.
FAU - Cai, Yu
AU  - Cai Y
AD  - Jiangsu Key Laboratory of Molecular and Functional Imaging, Department of 
      Radiology, Zhongda Hospital, Medical School of Southeast University, 87 Ding Jia 
      Qiao Road, Nanjing, 210009, China.
FAU - Xu, Ting-Ting
AU  - Xu TT
AD  - Jiangsu Key Laboratory of Molecular and Functional Imaging, Department of 
      Radiology, Zhongda Hospital, Medical School of Southeast University, 87 Ding Jia 
      Qiao Road, Nanjing, 210009, China.
FAU - Lu, Chun-Qiang
AU  - Lu CQ
AD  - Jiangsu Key Laboratory of Molecular and Functional Imaging, Department of 
      Radiology, Zhongda Hospital, Medical School of Southeast University, 87 Ding Jia 
      Qiao Road, Nanjing, 210009, China.
FAU - Ma, Yuan-Yuan
AU  - Ma YY
AD  - Jiangsu Key Laboratory of Molecular and Functional Imaging, Department of 
      Radiology, Zhongda Hospital, Medical School of Southeast University, 87 Ding Jia 
      Qiao Road, Nanjing, 210009, China.
FAU - Chang, Di
AU  - Chang D
AD  - Jiangsu Key Laboratory of Molecular and Functional Imaging, Department of 
      Radiology, Zhongda Hospital, Medical School of Southeast University, 87 Ding Jia 
      Qiao Road, Nanjing, 210009, China.
FAU - Zhang, Yi
AU  - Zhang Y
AD  - Jiangsu Key Laboratory of Molecular and Functional Imaging, Department of 
      Radiology, Zhongda Hospital, Medical School of Southeast University, 87 Ding Jia 
      Qiao Road, Nanjing, 210009, China.
FAU - Gu, Xiao-Chun
AU  - Gu XC
AD  - Jiangsu Key Laboratory of Molecular and Functional Imaging, Department of 
      Radiology, Zhongda Hospital, Medical School of Southeast University, 87 Ding Jia 
      Qiao Road, Nanjing, 210009, China.
FAU - Ju, Shenghong
AU  - Ju S
AD  - Jiangsu Key Laboratory of Molecular and Functional Imaging, Department of 
      Radiology, Zhongda Hospital, Medical School of Southeast University, 87 Ding Jia 
      Qiao Road, Nanjing, 210009, China. jsh0836@hotmail.com.
LA  - eng
GR  - No.81525014/National Nature Science Foundation of China/International
GR  - BL2103029/Jiangsu Provincial Special Program of Medical Science/International
GR  - BE2016782/Key Research and Development Program of Jiangsu Province/International
GR  - NSFC, 81830053/National Natural Science Foundation of China (CN)/International
GR  - NSFC, 81901809/National Nature Science Foundation of China/International
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20200402
PL  - United States
TA  - Transl Stroke Res
JT  - Translational stroke research
JID - 101517297
SB  - IM
MH  - Animals
MH  - Brain Ischemia/diagnostic imaging/immunology
MH  - Diabetes Mellitus, Type 2/*diagnostic imaging/immunology
MH  - Humans
MH  - Macrophages/*physiology
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Optical Imaging/*methods
MH  - *Phenotype
MH  - Stroke/*diagnostic imaging/immunology
MH  - T-Lymphocytes, Regulatory/*physiology
OTO - NOTNLM
OT  - Ischemic stroke
OT  - M2 macrophages/microglia
OT  - Optical imaging
OT  - Regulatory T cells
OT  - Type 2 diabetes mellitus
EDAT- 2020/04/03 06:00
MHDA- 2023/02/25 06:00
CRDT- 2020/04/03 06:00
PHST- 2019/06/02 00:00 [received]
PHST- 2020/03/12 00:00 [accepted]
PHST- 2020/03/10 00:00 [revised]
PHST- 2020/04/03 06:00 [pubmed]
PHST- 2023/02/25 06:00 [medline]
PHST- 2020/04/03 06:00 [entrez]
AID - 10.1007/s12975-020-00808-x [pii]
AID - 10.1007/s12975-020-00808-x [doi]
PST - ppublish
SO  - Transl Stroke Res. 2021 Feb;12(1):136-146. doi: 10.1007/s12975-020-00808-x. Epub 
      2020 Apr 2.