PMID- 32242463
OWN - NLM
STAT- MEDLINE
DCOM- 20210426
LR  - 20230426
IS  - 1360-0451 (Electronic)
IS  - 0954-0121 (Print)
IS  - 0954-0121 (Linking)
VI  - 33
IP  - 4
DP  - 2021 Apr
TI  - Predictors of pain-related functional impairment among people living with HIV on 
      long-term opioid therapy.
PG  - 507-515
LID - 10.1080/09540121.2020.1748866 [doi]
AB  - People living with HIV (PLWH) have high levels of functional impairment due to 
      pain, also called pain interference. Long-term opioid therapy (LTOT) is commonly 
      prescribed for chronic pain among PLWH. We sought to better understand the 
      predictors of pain interference, measured with the Brief Pain Inventory 
      Interference subscale (BPI-I), among PLWH with chronic pain on LTOT. Using a 
      prospective cohort of PLWH on LTOT we developed a model to identify predictors of 
      increased pain interference over 1 year of follow up. Participants (n = 166) were 
      34% female, 72% African American with a median age of 55 years, and 40% had 
      severe pain interference (BPI-I >/= 7). In multivariable models, substance use 
      disorder, depressive symptoms, PTSD symptoms, financial instability, and higher 
      opioid doses were associated with increased pain interference. Measures of 
      behavioral health and socioeconomic status had the most consistent association 
      with pain interference. In contrast, the biomedical aspects of chronic pain and 
      LTOT - comorbidities, duration of pain - were not predictive of pain 
      interference. PLWH with chronic pain on LTOT with lower socioeconomic status and 
      behavioral health symptoms have higher risk of pain interference. Addressing the 
      social determinants of health and providing access to behavioral health services 
      could improve patients' pain-related functional status.
FAU - Serota, David P
AU  - Serota DP
AUID- ORCID: 0000-0001-8505-6617
AD  - Division of Infectious Diseases, Department of Medicine, Emory University, 
      Atlanta, Georgia.
AD  - Division of Infectious Diseases, Department of Medicine, University of Miami 
      Miller School of Medicine, Miami, FL, USA.
FAU - Capozzi, Christine
AU  - Capozzi C
AD  - Clinical Addiction Research and Education (CARE) Unit, Section of General 
      Internal Medicine, Department of Medicine, Boston Medical Center, Boston, MA, 
      USA.
FAU - Lodi, Sara
AU  - Lodi S
AD  - Department of Biostatistics, Boston University School of Public Health, Boston, 
      MA, USA.
FAU - Colasanti, Jonathan A
AU  - Colasanti JA
AD  - Division of Infectious Diseases, Department of Medicine, Emory University, 
      Atlanta, Georgia.
FAU - Forman, Leah S
AU  - Forman LS
AD  - Biostatistics and Epidemiology Data Analytics Center (BEDAC), Boston University 
      School of Public Health, Boston, MA, USA.
FAU - Tsui, Judith I
AU  - Tsui JI
AD  - Department of Medicine, University of Washington, Seattle, WA, USA.
FAU - Walley, Alexander Y
AU  - Walley AY
AD  - Clinical Addiction Research and Education (CARE) Unit, Section of General 
      Internal Medicine, Department of Medicine, Boston Medical Center, Boston, MA, 
      USA.
AD  - Department of Community Health Sciences, Boston University School of Public 
      Health, Boston, MA, USA.
FAU - Lira, Marlene C
AU  - Lira MC
AD  - Clinical Addiction Research and Education (CARE) Unit, Section of General 
      Internal Medicine, Department of Medicine, Boston Medical Center, Boston, MA, 
      USA.
FAU - Samet, Jeffrey
AU  - Samet J
AD  - Clinical Addiction Research and Education (CARE) Unit, Section of General 
      Internal Medicine, Department of Medicine, Boston Medical Center, Boston, MA, 
      USA.
AD  - Department of Community Health Sciences, Boston University School of Public 
      Health, Boston, MA, USA.
FAU - Del Rio, Carlos
AU  - Del Rio C
AUID- ORCID: 0000-0002-0153-3517
AD  - Division of Infectious Diseases, Department of Medicine, Emory University, 
      Atlanta, Georgia.
FAU - Merlin, Jessica S
AU  - Merlin JS
AD  - Division of General Internal Medicine, Center for Research on Healthcare, 
      Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, 
      PA, USA.
LA  - eng
GR  - P30 AI050409/AI/NIAID NIH HHS/United States
GR  - TL1 TR002382/TR/NCATS NIH HHS/United States
GR  - R01 DA037768/DA/NIDA NIH HHS/United States
GR  - UL1 TR002378/TR/NCATS NIH HHS/United States
GR  - P30 AI027757/AI/NIAID NIH HHS/United States
GR  - P30 AI042853/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20200403
PL  - England
TA  - AIDS Care
JT  - AIDS care
JID - 8915313
RN  - 0 (Analgesics, Opioid)
SB  - IM
MH  - Analgesics, Opioid/*therapeutic use
MH  - Chronic Pain/*drug therapy
MH  - Cohort Studies
MH  - Female
MH  - HIV Infections/*complications/drug therapy
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - *Social Determinants of Health
PMC - PMC7541400
MID - NIHMS1588734
OTO - NOTNLM
OT  - Chronic pain
OT  - opioid use
OT  - social determinants of health
COIS- Conflict of Interest The authors report no conflicts of interest
EDAT- 2020/04/04 06:00
MHDA- 2021/04/27 06:00
PMCR- 2022/04/01
CRDT- 2020/04/04 06:00
PHST- 2020/04/04 06:00 [pubmed]
PHST- 2021/04/27 06:00 [medline]
PHST- 2020/04/04 06:00 [entrez]
PHST- 2022/04/01 00:00 [pmc-release]
AID - 10.1080/09540121.2020.1748866 [doi]
PST - ppublish
SO  - AIDS Care. 2021 Apr;33(4):507-515. doi: 10.1080/09540121.2020.1748866. Epub 2020 
      Apr 3.