PMID- 32244100 OWN - NLM STAT- MEDLINE DCOM- 20201120 LR - 20201120 IS - 1873-6750 (Electronic) IS - 0160-4120 (Linking) VI - 139 DP - 2020 Jun TI - Essential trace elements in placental tissue and risk for fetal neural tube defects. PG - 105688 LID - S0160-4120(19)34044-9 [pii] LID - 10.1016/j.envint.2020.105688 [doi] AB - This study examined the associations between concentrations of cobalt (Co), iron (Fe), manganese (Mn), molybdenum (Mo), selenium (Se), and zinc (Zn) in placental tissue and risks for NTDs with a case-control design consisting of 408 fetuses or newborns with neural tube defects (NTDs) and 593 non-malformed fetuses or newborns. The concentrations of Zn and Fe were determined by inductively coupled plasma-emission spectrometer and the other four elements by inductively coupled plasma-mass spectrometer. Element concentrations were presented in ng/g or microg/g dry weight of placental tissue. The associations between the levels of each of the six ETEs and risk for NTDs were evaluated using multivariable logistic regression, and the associations between overall levels of all six ETEs and risk for NTDs were examined using Bayesian kernel machine regression (BKMR). Concentrations above the median concentration of all participants for an individual element were associated with increased risk for NTDs: Mn, 3.17-fold (95% CI 2.35-4.28); Mo, 3.73-fold (95% CI 2.74-5.07); Se, 3.28-fold (95% CI 2.44-4.42); and Zn, 2.85-fold (95% CI 2.13-3.83), and a decreased risk for Co [OR, 0.18 (95% CI 0.14-0.25)]. The risk for NTDs increased with the increase in the concentrations of Mn, Mo, Se, and Zn, but decreased for Co, in the second, third, and fourth quartiles, respectively, compared to their lowest quartile (all Ps(trend) < 0.01). In BKMR model, the risk for NTDs increased constantly when the overall exposure levels were higher than the median of the six ETEs as a co-exposure mixture, and the associations between Co, Mn, Se, and Zn and NTD risk remained when the remaining five elements were taken into consideration simultaneously. Taken together, when evaluated individually, higher levels of Mn, Se, and Zn in placental tissue are associated with increased risk for NTDs, while higher levels of Co are associated with decreased risk for NTDs; when examined collectively, the risk of NTDs increases continuously when exposure levels are higher than the median of the six ETE mixture. CI - Copyright (c) 2020 The Authors. Published by Elsevier Ltd.. All rights reserved. FAU - Yin, Shengju AU - Yin S AD - Institute of Reproductive and Child Health/National Health Commission Key Laboratory of Reproductive Health, Peking University, Beijing 100191, China; Department of Pharmacology, School of Basic Medical Sciences, Peking University, Beijing 100191, China. FAU - Wang, Chengrong AU - Wang C AD - Institute of Reproductive and Child Health/National Health Commission Key Laboratory of Reproductive Health, Peking University, Beijing 100191, China; Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing 100026, China; Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China. FAU - Wei, Jing AU - Wei J AD - Institute of Reproductive and Child Health/National Health Commission Key Laboratory of Reproductive Health, Peking University, Beijing 100191, China; Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China. FAU - Wang, Di AU - Wang D AD - Institute of Reproductive and Child Health/National Health Commission Key Laboratory of Reproductive Health, Peking University, Beijing 100191, China; Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China. FAU - Jin, Lei AU - Jin L AD - Institute of Reproductive and Child Health/National Health Commission Key Laboratory of Reproductive Health, Peking University, Beijing 100191, China; Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China. FAU - Liu, Jufen AU - Liu J AD - Institute of Reproductive and Child Health/National Health Commission Key Laboratory of Reproductive Health, Peking University, Beijing 100191, China; Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China. FAU - Wang, Linlin AU - Wang L AD - Institute of Reproductive and Child Health/National Health Commission Key Laboratory of Reproductive Health, Peking University, Beijing 100191, China; Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China. FAU - Li, Zhiwen AU - Li Z AD - Institute of Reproductive and Child Health/National Health Commission Key Laboratory of Reproductive Health, Peking University, Beijing 100191, China; Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China. FAU - Ren, Aiguo AU - Ren A AD - Institute of Reproductive and Child Health/National Health Commission Key Laboratory of Reproductive Health, Peking University, Beijing 100191, China; Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing 100026, China; Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China. Electronic address: renag@bjmu.edu.cn. FAU - Yin, Chenghong AU - Yin C AD - Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing 100026, China. Electronic address: yinchh@ccmu.edu.cn. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20200331 PL - Netherlands TA - Environ Int JT - Environment international JID - 7807270 RN - 0 (Trace Elements) RN - H6241UJ22B (Selenium) SB - IM MH - Bayes Theorem MH - Female MH - Fetus MH - Humans MH - Infant, Newborn MH - *Neural Tube Defects/epidemiology MH - Pregnancy MH - *Selenium MH - *Trace Elements OTO - NOTNLM OT - Essential trace element OT - Fetus OT - Gestation OT - Neural tube defects OT - Placental tissue COIS- Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2020/04/04 06:00 MHDA- 2020/11/21 06:00 CRDT- 2020/04/04 06:00 PHST- 2019/11/05 00:00 [received] PHST- 2020/03/21 00:00 [revised] PHST- 2020/03/23 00:00 [accepted] PHST- 2020/04/04 06:00 [pubmed] PHST- 2020/11/21 06:00 [medline] PHST- 2020/04/04 06:00 [entrez] AID - S0160-4120(19)34044-9 [pii] AID - 10.1016/j.envint.2020.105688 [doi] PST - ppublish SO - Environ Int. 2020 Jun;139:105688. doi: 10.1016/j.envint.2020.105688. Epub 2020 Mar 31.