PMID- 32244712
OWN - NLM
STAT- MEDLINE
DCOM- 20201228
LR  - 20240328
IS  - 2072-6643 (Electronic)
IS  - 2072-6643 (Linking)
VI  - 12
IP  - 4
DP  - 2020 Apr 1
TI  - Erythropoiesis and Red Cell Indices Undergo Adjustments during Pregnancy in 
      Response to Maternal Body Size but not Inflammation.
LID - 10.3390/nu12040975 [doi]
LID - 975
AB  - During human pregnancy, iron requirements gradually increase, leading to higher 
      amounts of erythropoietin (EPO) and reticulocytes, and changes in erythrocyte 
      size and density. Women with pregestational obesity experience "obesity 
      hypoferremia" during pregnancy, which alters iron homeostasis. In this study we 
      aimed to describe the relationship between EPO and iron nutrition status during 
      nonanemic pregnancy, and to explore whether obesity and inflammation influence 
      erythropoiesis and red cell indices. We conducted a secondary analysis of a 
      cohort followed throughout pregnancy. Participants were nonanemic women assigned 
      to two study groups based on pregestational body mass index (pgBMI): adequate 
      weight (AW, n = 53) or obesity (Ob, n = 40). All received a multivitamin 
      supplement. At gestational ages (GA) 13, 21, 28 and 34, we measured hemoglobin 
      and red cell indices with an ACT-5DIFF hematology counter, and reticulocyte 
      percentage by manual cell counting. EPO, interleukin (IL-6) and markers of iron 
      status, i.e., hepcidin, serum transferrin receptor (sTfr) and ferritin, were 
      measured by ELISA. Bivariate correlations showed that EPO was positively 
      associated with pgBMI, GA, sTfr and IL-6, but negatively associated with 
      hepcidin, ferritin and hemoglobin, and unrelated to iron intake. Generalized 
      linear models adjusted for confounding factors showed that EPO and erythrocyte 
      concentrations were significantly higher in women in the Ob group, while mean 
      corpuscular volume (MCV), mean corpuscular hemoglobin (MCH) and red cell 
      distribution width (RDW) were lower; reticulocytes and mean corpuscular 
      hemoglobin concentration (MCHC) were not different. Differences were not altered 
      when controlling for inflammation (IL-6). These changes suggest that, in addition 
      to altering iron metabolism, a larger maternal body size during pregnancy results 
      in higher erythropoiesis without increasing hemoglobin, which is exhibited in the 
      latter being distributed among more and smaller erythrocytes.
FAU - Vega-Sanchez, Rodrigo
AU  - Vega-Sanchez R
AD  - Departamento de Nutricion y Bioprogramacion, Instituto Nacional de Perinatologia 
      Isidro Espinosa de los Reyes, Ciudad de Mexico CP. 11000, Mexico.
FAU - Tolentino-Dolores, Mari Cruz
AU  - Tolentino-Dolores MC
AD  - Departamento de Nutricion y Bioprogramacion, Instituto Nacional de Perinatologia 
      Isidro Espinosa de los Reyes, Ciudad de Mexico CP. 11000, Mexico.
FAU - Cerezo-Rodriguez, Blanca
AU  - Cerezo-Rodriguez B
AD  - Departamento de Ciencias de la Salud, Universidad del Valle de Mexico, Coyoacan, 
      Ciudad de Mexico CP. 04910, Mexico.
FAU - Chehaibar-Besil, Georgette
AU  - Chehaibar-Besil G
AD  - Departamento de Salud, Universidad Iberoamericana, Lomas de Santa Fe, Ciudad de 
      Mexico CP.01219, Mexico.
FAU - Flores-Quijano, Maria Eugenia
AU  - Flores-Quijano ME
AD  - Departamento de Nutricion y Bioprogramacion, Instituto Nacional de Perinatologia 
      Isidro Espinosa de los Reyes, Ciudad de Mexico CP. 11000, Mexico.
LA  - eng
GR  - 87397/Consejo Nacional de Ciencia y Tecnologia/
GR  - 212250-49531/Instituto Nacional de Perinatologia/
PT  - Journal Article
DEP - 20200401
PL  - Switzerland
TA  - Nutrients
JT  - Nutrients
JID - 101521595
RN  - 0 (Inflammation Mediators)
RN  - 0 (Interleukin-6)
RN  - 11096-26-7 (Erythropoietin)
RN  - E1UOL152H7 (Iron)
SB  - IM
MH  - Adult
MH  - *Body Size
MH  - *Erythrocyte Indices
MH  - Erythrocytes/pathology
MH  - Erythropoiesis/*physiology
MH  - Erythropoietin/blood
MH  - Female
MH  - Humans
MH  - Inflammation/blood
MH  - Inflammation Mediators/blood
MH  - Interleukin-6/blood
MH  - Iron/metabolism
MH  - *Maternal Nutritional Physiological Phenomena
MH  - Obesity, Maternal/*blood
MH  - Pregnancy/*blood/*physiology
MH  - Young Adult
PMC - PMC7230988
OTO - NOTNLM
OT  - erythropoietin
OT  - hemoglobin
OT  - hepcidin
OT  - inflammation
OT  - maternal obesity
OT  - pregnancy
OT  - red cell indices
COIS- The authors declare no conflict of interest.
EDAT- 2020/04/05 06:00
MHDA- 2020/12/29 06:00
PMCR- 2020/04/01
CRDT- 2020/04/05 06:00
PHST- 2020/02/19 00:00 [received]
PHST- 2020/03/24 00:00 [revised]
PHST- 2020/03/26 00:00 [accepted]
PHST- 2020/04/05 06:00 [entrez]
PHST- 2020/04/05 06:00 [pubmed]
PHST- 2020/12/29 06:00 [medline]
PHST- 2020/04/01 00:00 [pmc-release]
AID - nu12040975 [pii]
AID - nutrients-12-00975 [pii]
AID - 10.3390/nu12040975 [doi]
PST - epublish
SO  - Nutrients. 2020 Apr 1;12(4):975. doi: 10.3390/nu12040975.