PMID- 32245055
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200928
IS  - 2077-0383 (Print)
IS  - 2077-0383 (Electronic)
IS  - 2077-0383 (Linking)
VI  - 9
IP  - 3
DP  - 2020 Mar 20
TI  - The Role of Bone Marrow Mesenchymal Stem Cell Derived Extracellular Vesicles 
      (MSC-EVs) in Normal and Abnormal Hematopoiesis and Their Therapeutic Potential.
LID - 10.3390/jcm9030856 [doi]
LID - 856
AB  - Mesenchymal stem cells (MSCs) represent a heterogeneous cellular population 
      responsible for the support, maintenance, and regulation of normal hematopoietic 
      stem cells (HSCs). In many hematological malignancies, however, MSCs are 
      deregulated and may create an inhibitory microenvironment able to induce the 
      disease initiation and/or progression. MSCs secrete soluble factors including 
      extracellular vesicles (EVs), which may influence the bone marrow (BM) 
      microenvironment via paracrine mechanisms. MSC-derived EVs (MSC-EVs) may even 
      mimic the effects of MSCs from which they originate. Therefore, MSC-EVs 
      contribute to the BM homeostasis but may also display multiple roles in the 
      induction and maintenance of abnormal hematopoiesis. Compared to MSCs, MSC-EVs 
      have been considered a more promising tool for therapeutic purposes including the 
      prevention and treatment of Graft Versus Host Disease (GVHD) following allogenic 
      HSC transplantation (HSCT). There are, however, still unanswered questions such 
      as the molecular and cellular mechanisms associated with the supportive effect of 
      MSC-EVs, the impact of the isolation, purification, large-scale production, 
      storage conditions, MSC source, and donor characteristics on MSC-EV biological 
      effects as well as the optimal dose and safety for clinical usage. This review 
      summarizes the role of MSC-EVs in normal and malignant hematopoiesis and their 
      potential contribution in treating GVHD.
FAU - Batsali, Aristea K
AU  - Batsali AK
AD  - Haemopoiesis Research Laboratory, School of Medicine, University of Crete, 71003 
      Heraklion, Greece.
FAU - Georgopoulou, Anthie
AU  - Georgopoulou A
AD  - Haemopoiesis Research Laboratory, School of Medicine, University of Crete, 71003 
      Heraklion, Greece.
FAU - Mavroudi, Irene
AU  - Mavroudi I
AD  - Haemopoiesis Research Laboratory, School of Medicine, University of Crete, 71003 
      Heraklion, Greece.
FAU - Matheakakis, Angelos
AU  - Matheakakis A
AD  - Haemopoiesis Research Laboratory, School of Medicine, University of Crete, 71003 
      Heraklion, Greece.
AD  - Department of Hematology, School of Medicine, University of Crete, 71003 
      Heraklion, Greece.
FAU - Pontikoglou, Charalampos G
AU  - Pontikoglou CG
AD  - Haemopoiesis Research Laboratory, School of Medicine, University of Crete, 71003 
      Heraklion, Greece.
AD  - Department of Hematology, School of Medicine, University of Crete, 71003 
      Heraklion, Greece.
FAU - Papadaki, Helen A
AU  - Papadaki HA
AD  - Haemopoiesis Research Laboratory, School of Medicine, University of Crete, 71003 
      Heraklion, Greece.
AD  - Department of Hematology, School of Medicine, University of Crete, 71003 
      Heraklion, Greece.
LA  - eng
GR  - Kappa.Alpha. 2018EP40200001/Region of Crete/
PT  - Journal Article
PT  - Review
DEP - 20200320
PL  - Switzerland
TA  - J Clin Med
JT  - Journal of clinical medicine
JID - 101606588
PMC - PMC7141498
OTO - NOTNLM
OT  - MSC-EVs
OT  - exosomes
OT  - extracellular vesicles (EVs)
OT  - hematological malignancies
OT  - hematopoietic stem cell transplantation (HSCT)
OT  - mesenchymal stem cells (MSCs)
OT  - micro-vesicles (MVs)
COIS- The authors declare no conflict of interest.
EDAT- 2020/04/05 06:00
MHDA- 2020/04/05 06:01
PMCR- 2020/03/20
CRDT- 2020/04/05 06:00
PHST- 2020/02/11 00:00 [received]
PHST- 2020/03/12 00:00 [revised]
PHST- 2020/03/17 00:00 [accepted]
PHST- 2020/04/05 06:00 [entrez]
PHST- 2020/04/05 06:00 [pubmed]
PHST- 2020/04/05 06:01 [medline]
PHST- 2020/03/20 00:00 [pmc-release]
AID - jcm9030856 [pii]
AID - jcm-09-00856 [pii]
AID - 10.3390/jcm9030856 [doi]
PST - epublish
SO  - J Clin Med. 2020 Mar 20;9(3):856. doi: 10.3390/jcm9030856.