PMID- 32245631
OWN - NLM
STAT- MEDLINE
DCOM- 20200812
LR  - 20200812
IS  - 1879-1913 (Electronic)
IS  - 0002-9149 (Linking)
VI  - 125
IP  - 10
DP  - 2020 May 15
TI  - Effect of Recruitment of Acute Coronary Collaterals on In-Hospital Mortality and 
      on Left Ventricular Function in Patients Presenting With ST Elevation Myocardial 
      Infarction.
PG  - 1455-1460
LID - S0002-9149(20)30193-4 [pii]
LID - 10.1016/j.amjcard.2020.02.023 [doi]
AB  - Recruitment of the coronary collateral circulation is frequently observed during 
      ST elevation myocardial infarction (STEMI) and is of uncertain significance. The 
      aim of this study was to identify and determine the predictors and prognostic 
      implications of the presence of robust collaterals during STEMI. All patients 
      presenting to a large tertiary centre with a STEMI undergoing percutaneous 
      coronary intervention from 2010 to 2018 were reviewed. Patients with poor 
      collateral recruitment were defined as those with Rentrop grade 0 or 1 
      collaterals, whilst patients with robust collateral recruitment were defined as 
      Rentrop grade 2 or 3. A total of 1,625 patients were included in the study, with 
      1,280 (78.8%) patients having poor collateral recruitment and 345 patients 
      (21.2%) having robust collateral recruitment. Patients with robust collaterals 
      were younger (63.1 vs 65.1 years, p < 0.05), had a longer ischemic time (628.5 
      minutes vs 433.1 minutes, p < 0.0001), and more likely to have a chronic total 
      occlusion of a noninfarct related artery (10.4% vs 5.3%, p < 0.001). The presence 
      of robust collaterals was associated with higher rates of normal or mildly 
      impaired left ventricular function (83.5% vs 63.2%, p < 0.0001) and lower 
      in-hospital mortality (2.1% vs 7.6%, p < 0.0001). After correcting for left 
      ventricular function, collateral recruitment was not an independent predictor of 
      mortality. In conclusion, in patients presenting with STEMI, the presence of 
      robust coronary collaterals appears to be associated with improved left 
      ventricular function. Further research is required to identify mechanisms of 
      collateral maturation and recruitment.
CI  - Copyright (c) 2020 Elsevier Inc. All rights reserved.
FAU - Allahwala, Usaid K
AU  - Allahwala UK
AD  - Department of Cardiology, Royal North Shore Hospital, Sydney, Australia; The 
      University of Sydney, Sydney, Australia. Electronic address: 
      usaid.allahwala@gmail.com.
FAU - Weaver, James C
AU  - Weaver JC
AD  - Department of Cardiology, Royal Prince Alfred Hospital, Sydney, Australia; The 
      University of New South Wales, New South Wales, Australia.
FAU - Nelson, Gregory I
AU  - Nelson GI
AD  - Department of Cardiology, Royal North Shore Hospital, Sydney, Australia.
FAU - Nour, Daniel
AU  - Nour D
AD  - Department of Cardiology, Royal North Shore Hospital, Sydney, Australia.
FAU - Ray, Max
AU  - Ray M
AD  - Department of Cardiology, Royal North Shore Hospital, Sydney, Australia.
FAU - Ciofani, Jonathan L
AU  - Ciofani JL
AD  - Department of Cardiology, Royal North Shore Hospital, Sydney, Australia.
FAU - Ward, Michael
AU  - Ward M
AD  - Department of Cardiology, Royal North Shore Hospital, Sydney, Australia.
FAU - Figtree, Gemma
AU  - Figtree G
AD  - Department of Cardiology, Royal North Shore Hospital, Sydney, Australia; The 
      University of Sydney, Sydney, Australia.
FAU - Hansen, Peter
AU  - Hansen P
AD  - Department of Cardiology, Royal North Shore Hospital, Sydney, Australia.
FAU - Bhindi, Ravinay
AU  - Bhindi R
AD  - Department of Cardiology, Royal North Shore Hospital, Sydney, Australia; The 
      University of Sydney, Sydney, Australia.
LA  - eng
PT  - Journal Article
DEP - 20200304
PL  - United States
TA  - Am J Cardiol
JT  - The American journal of cardiology
JID - 0207277
SB  - IM
MH  - Aged
MH  - Collateral Circulation/*physiology
MH  - Coronary Angiography
MH  - Coronary Circulation/*physiology
MH  - Female
MH  - *Hospital Mortality
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Percutaneous Coronary Intervention
MH  - Prognosis
MH  - ST Elevation Myocardial Infarction/*mortality/*physiopathology/surgery
MH  - Ventricular Function, Left/*physiology
EDAT- 2020/04/05 06:00
MHDA- 2020/08/13 06:00
CRDT- 2020/04/05 06:00
PHST- 2019/12/02 00:00 [received]
PHST- 2020/02/03 00:00 [revised]
PHST- 2020/02/06 00:00 [accepted]
PHST- 2020/04/05 06:00 [pubmed]
PHST- 2020/08/13 06:00 [medline]
PHST- 2020/04/05 06:00 [entrez]
AID - S0002-9149(20)30193-4 [pii]
AID - 10.1016/j.amjcard.2020.02.023 [doi]
PST - ppublish
SO  - Am J Cardiol. 2020 May 15;125(10):1455-1460. doi: 10.1016/j.amjcard.2020.02.023. 
      Epub 2020 Mar 4.