PMID- 32245993
OWN - NLM
STAT- MEDLINE
DCOM- 20201125
LR  - 20210403
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 10
IP  - 1
DP  - 2020 Apr 3
TI  - Gradual wiring of olfactory input to amygdala feedback circuits.
PG  - 5871
LID - 10.1038/s41598-020-62457-2 [doi]
LID - 5871
AB  - The amygdala facilitates odor driven behavioral responses by enhancing the 
      saliency of olfactory signals. Before this processing, olfactory input is refined 
      through the feedback provided by amygdala corticofugal projection (ACPs). 
      Although the saliency of odor signals is subject to developmental changes, the 
      stage at which this cortical feedback first occurs is not known. Using 
      optogenetically-assisted intracellular recordings of the mouse cortical amygdala, 
      we identified changes in the electrophysiological properties of ACPs at different 
      developmental stages. These were consistent with a decrease in neuronal 
      excitability and an increase in the amount of incoming accessory olfactory bulb 
      (AOB) inputs, as confirmed by estimates of release probability, quantal size and 
      contact number at the AOB-to-ACP synapse. Moreover, the proportion of ACPs 
      activated in response to odors was dependent on the stage of development as 
      revealed by c-Fos expression analysis. These results update standard accounts of 
      how the amygdala processes social signals by emphasizing the occurrence of 
      critical periods in the development of its sensory gating functions.
FAU - Oboti, Livio
AU  - Oboti L
AD  - Center for Neuroscience Research, Children's National Health System, Washington, 
      DC, 20010, USA. livio.oboti@hu-berlin.de.
AD  - Department of Behavioral Physiology, Humboldt Universitat zu Berlin, Berlin, 
      10115, Germany. livio.oboti@hu-berlin.de.
FAU - Sokolowski, Katie
AU  - Sokolowski K
AD  - Center for Neuroscience Research, Children's National Health System, Washington, 
      DC, 20010, USA.
LA  - eng
GR  - F32 DA035754/DA/NIDA NIH HHS/United States
GR  - U54 HD090257/HD/NICHD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20200403
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
SB  - IM
MH  - Amygdala/*physiology
MH  - Animals
MH  - Electrophysiological Phenomena
MH  - Feedback, Physiological/physiology
MH  - Female
MH  - Male
MH  - Mice
MH  - Neural Pathways/*physiology
MH  - Odorants
MH  - Olfactory Bulb/physiology
MH  - Optogenetics
MH  - Smell/*physiology
MH  - Synapses/physiology
PMC - PMC7125095
COIS- The authors declare no competing interests.
EDAT- 2020/04/05 06:00
MHDA- 2020/11/26 06:00
PMCR- 2020/04/03
CRDT- 2020/04/05 06:00
PHST- 2019/10/14 00:00 [received]
PHST- 2020/03/11 00:00 [accepted]
PHST- 2020/04/05 06:00 [entrez]
PHST- 2020/04/05 06:00 [pubmed]
PHST- 2020/11/26 06:00 [medline]
PHST- 2020/04/03 00:00 [pmc-release]
AID - 10.1038/s41598-020-62457-2 [pii]
AID - 62457 [pii]
AID - 10.1038/s41598-020-62457-2 [doi]
PST - epublish
SO  - Sci Rep. 2020 Apr 3;10(1):5871. doi: 10.1038/s41598-020-62457-2.