PMID- 32246301
OWN - NLM
STAT- MEDLINE
DCOM- 20210908
LR  - 20211204
IS  - 1573-6768 (Electronic)
IS  - 1389-5729 (Linking)
VI  - 21
IP  - 5
DP  - 2020 Oct
TI  - The roles of MTOR and miRNAs in endothelial cell senescence.
PG  - 517-530
LID - 10.1007/s10522-020-09876-w [doi]
AB  - Accumulation of senescent cells in vascular endothelium is known to contribute to 
      vascular aging and increases the risk of developing cardiovascular diseases. The 
      involvement of classical pathways such as p53/p21 and p16/pRB in cellular 
      senescence are well described but there are emerging evidence supporting the 
      increasingly important role of mammalian target of rapamycin (MTOR) as driver of 
      cellular senescence via these pathways or other effector molecules. MicroRNAs 
      (miRNAs) are a highly conserved group of small non-coding RNAs (18-25 
      nucleotides), instrumental in modulating the expression of target genes 
      associated with various biological and cellular processes including cellular 
      senescence. The inhibition of MTOR activity is predominantly linked to cellular 
      senescence blunting and prolonged lifespan in model organisms. To date, known 
      miRNAs regulating MTOR in endothelial cell senescence remain limited. Herein, 
      this review discusses the roles of MTOR and MTOR-associated miRNAs in regulating 
      endothelial cell senescence, including the crosstalk between MTOR Complex 1 
      (MTORC1) and cell cycle pathways and the emerging role of MTORC2 in cellular 
      senescence. New insights on how MTOR and miRNAs coordinate underlying molecular 
      mechanisms of endothelial senescence will provide deeper understanding and 
      clarity to the complexity of the regulation of cellular senescence.
FAU - Khor, Eng-Soon
AU  - Khor ES
AD  - Department of Pharmacology, Faculty of Medicine, University of Malaya, 50603, 
      Kuala Lumpur, Malaysia.
FAU - Wong, Pooi-Fong
AU  - Wong PF
AUID- ORCID: 0000-0002-6705-2521
AD  - Department of Pharmacology, Faculty of Medicine, University of Malaya, 50603, 
      Kuala Lumpur, Malaysia. wongpf@um.edu.my.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20200403
PL  - Netherlands
TA  - Biogerontology
JT  - Biogerontology
JID - 100930043
RN  - 0 (MicroRNAs)
RN  - EC 2.7.11.1 (Mechanistic Target of Rapamycin Complex 1)
RN  - EC 2.7.11.1 (Mechanistic Target of Rapamycin Complex 2)
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
SB  - IM
MH  - *Cellular Senescence
MH  - Endothelial Cells/*cytology
MH  - Humans
MH  - Mechanistic Target of Rapamycin Complex 1
MH  - Mechanistic Target of Rapamycin Complex 2
MH  - MicroRNAs/*physiology
MH  - TOR Serine-Threonine Kinases/*physiology
OTO - NOTNLM
OT  - Endothelium
OT  - MTOR
OT  - MicroRNAs
OT  - Senescence
OT  - Vascular aging
EDAT- 2020/04/05 06:00
MHDA- 2021/09/09 06:00
CRDT- 2020/04/05 06:00
PHST- 2020/01/21 00:00 [received]
PHST- 2020/03/30 00:00 [accepted]
PHST- 2020/04/05 06:00 [pubmed]
PHST- 2021/09/09 06:00 [medline]
PHST- 2020/04/05 06:00 [entrez]
AID - 10.1007/s10522-020-09876-w [pii]
AID - 10.1007/s10522-020-09876-w [doi]
PST - ppublish
SO  - Biogerontology. 2020 Oct;21(5):517-530. doi: 10.1007/s10522-020-09876-w. Epub 
      2020 Apr 3.