PMID- 32248862
OWN - NLM
STAT- MEDLINE
DCOM- 20221124
LR  - 20221218
IS  - 1469-8978 (Electronic)
IS  - 0033-2917 (Linking)
VI  - 51
IP  - 12
DP  - 2021 Sep
TI  - Conversion to psychosis in adolescents and adults: similar proportions, different 
      predictors.
PG  - 2003-2011
LID - 10.1017/S0033291720000756 [doi]
AB  - BACKGROUND: Age effects may be important for improving models for the prediction 
      of conversion to psychosis for individuals in the clinical high risk (CHR) state. 
      This study aimed to explore whether adolescent CHR individuals (ages 9-17 years) 
      differ significantly from adult CHR individuals (ages 18-45 years) in terms of 
      conversion rates and predictors. METHOD: Consecutive CHR individuals (N = 517) 
      were assessed for demographic and clinical characteristics and followed up for 3 
      years. Individuals with CHR were classified as adolescent (n = 244) or adult (n = 
      273) groups. Age-specific prediction models of psychosis were generated 
      separately using Cox regression. RESULTS: Similar conversion rates were found 
      between age groups; 52 out of 216 (24.1%) adolescent CHR individuals and 55 out 
      of 219 (25.1%) CHR adults converted to psychosis. The conversion outcome was best 
      predicted by negative symptoms compared to other clinical variables in CHR 
      adolescents (chi(2) = 7.410, p = 0.006). In contrast, positive symptoms better 
      predicted conversion in CHR adults (chi(2) = 6.585, p = 0.01). CONCLUSIONS: 
      Adolescent and adult CHR individuals may require a different approach to early 
      identification and prediction. These results can inform the development of more 
      precise prediction models based on age-specific approaches.
FAU - Zhang, TianHong
AU  - Zhang T
AD  - Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, 
      Shanghai Key Laboratory of Psychotic Disorders, Shanghai200030, PR China.
FAU - Xu, LiHua
AU  - Xu L
AD  - Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, 
      Shanghai Key Laboratory of Psychotic Disorders, Shanghai200030, PR China.
FAU - Chen, Ying
AU  - Chen Y
AD  - Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, 
      Shanghai Key Laboratory of Psychotic Disorders, Shanghai200030, PR China.
FAU - Wei, YanYan
AU  - Wei Y
AD  - Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, 
      Shanghai Key Laboratory of Psychotic Disorders, Shanghai200030, PR China.
FAU - Tang, XiaoChen
AU  - Tang X
AD  - Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, 
      Shanghai Key Laboratory of Psychotic Disorders, Shanghai200030, PR China.
FAU - Hu, YeGang
AU  - Hu Y
AD  - Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, 
      Shanghai Key Laboratory of Psychotic Disorders, Shanghai200030, PR China.
FAU - Li, ZhiXing
AU  - Li Z
AD  - Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, 
      Shanghai Key Laboratory of Psychotic Disorders, Shanghai200030, PR China.
FAU - Gan, RanPiao
AU  - Gan R
AD  - Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, 
      Shanghai Key Laboratory of Psychotic Disorders, Shanghai200030, PR China.
FAU - Wu, GuiSen
AU  - Wu G
AD  - Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, 
      Shanghai Key Laboratory of Psychotic Disorders, Shanghai200030, PR China.
FAU - Cui, HuiRu
AU  - Cui H
AD  - Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, 
      Shanghai Key Laboratory of Psychotic Disorders, Shanghai200030, PR China.
FAU - Tang, YingYing
AU  - Tang Y
AD  - Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, 
      Shanghai Key Laboratory of Psychotic Disorders, Shanghai200030, PR China.
FAU - Hui, Li
AU  - Hui L
AD  - Institute of Mental Health, The Affiliated Guangji Hospital of Soochow 
      University, Soochow University, Suzhou215137, Jiangsu, PR China.
FAU - Li, ChunBo
AU  - Li C
AD  - Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, 
      Shanghai Key Laboratory of Psychotic Disorders, Shanghai200030, PR China.
FAU - Wang, JiJun
AU  - Wang J
AD  - Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, 
      Shanghai Key Laboratory of Psychotic Disorders, Shanghai200030, PR China.
AD  - Bio-X Institutes, Key Laboratory for the Genetics of Developmental and 
      Neuropsychiatric Disorders (Ministry of Education), Shanghai, PR China.
AD  - Brain Science and Technology Research Center, Shanghai Jiao Tong University, 
      Shanghai, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20200406
PL  - England
TA  - Psychol Med
JT  - Psychological medicine
JID - 1254142
SB  - IM
MH  - Adult
MH  - Adolescent
MH  - Humans
MH  - Child
MH  - Young Adult
MH  - Middle Aged
MH  - Psychiatric Status Rating Scales
MH  - *Psychotic Disorders/epidemiology/diagnosis
MH  - Risk Assessment
OTO - NOTNLM
OT  - Cohort study
OT  - early onset
OT  - schizophrenia
OT  - transition
OT  - ultra high risk
EDAT- 2020/04/07 06:00
MHDA- 2022/11/25 06:00
CRDT- 2020/04/07 06:00
PHST- 2020/04/07 06:00 [pubmed]
PHST- 2022/11/25 06:00 [medline]
PHST- 2020/04/07 06:00 [entrez]
AID - S0033291720000756 [pii]
AID - 10.1017/S0033291720000756 [doi]
PST - ppublish
SO  - Psychol Med. 2021 Sep;51(12):2003-2011. doi: 10.1017/S0033291720000756. Epub 2020 
      Apr 6.