PMID- 32249067
OWN - NLM
STAT- MEDLINE
DCOM- 20210518
LR  - 20210518
IS  - 1916-7075 (Electronic)
IS  - 0828-282X (Linking)
VI  - 36
IP  - 7
DP  - 2020 Jul
TI  - A Novel Risk Stratification Score for Sudden Cardiac Death Prediction in 
      Middle-Aged, Nonischemic Dilated Cardiomyopathy Patients: The ESTIMATED Score.
PG  - 1121-1129
LID - S0828-282X(19)31433-3 [pii]
LID - 10.1016/j.cjca.2019.11.009 [doi]
AB  - BACKGROUND: We aimed to develop a risk score (LGE Based Prediction of SCD Risk in 
      Nonischemic Dilated Cardiomyopathy [ESTIMATED]) based on late gadolinium 
      enhancement (LGE) cardiac magnetic resonance to predict sudden cardiac death 
      (SCD) in patients with nonischemic dilated cardiomyopathy (NIDCM) and left 
      ventricular ejection fraction </= 35%. METHODS: We recruited 395 consecutive 
      middle-aged patients with NIDCM and performed 3-year follow-up for SCD events. 
      The score was developed and verified in 295 primary prevention patients, and the 
      predictive value was confirmed by comparing the SCD events between the high-risk 
      patients stratified by the score and 100 secondary prevention patients. RESULTS: 
      The ESTIMATED score (constructed by the LGE extent > 14%, syncope, atrial 
      flutter/fibrillation, nonsustained ventricular tachycardia, advanced 
      atrioventricular block, and age </= 20 or > 50 years) showed good calibrations for 
      SCD prediction in the derivation (C-statistic: 0.80, 95% confidence interval: 
      0.74-0.86) and validation set (C-statistic: 0.80, 95% confidence interval: 
      0.71-0.87). By the score, 20.3% of primary prevention patients were categorized 
      as high risk (>/= 3 points), 28.1% as intermediate risk (2 points), and 51.6% as 
      low risk (0-1 points) for 3-year SCD events (45.9% vs 20.1% vs 5.1%, P < 0.0001). 
      The 3-year SCD events were also well in agreement with the score stratification 
      in patients without implantable cardioverter-defibrillator. High-risk primary 
      prevention patients selected by the score in the derivation and validation sets 
      had 3-year SCD events comparable with that in secondary prevention patients 
      (47.6% vs 40.6% vs 38.7%, P = 0.81). CONCLUSIONS: Our study derived and validated 
      an LGE-based (ESTIMATED) risk score providing refined SCD prediction. The score 
      may help to identify candidates for primary prevention implantable 
      cardioverter-defibrillator in patients with NIDCM.
CI  - Copyright (c) 2020 Canadian Cardiovascular Society. Published by Elsevier Inc. All 
      rights reserved.
FAU - Li, Xiaofei
AU  - Li X
AD  - Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular 
      Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, 
      Beijing, China.
FAU - Fan, Xiaohan
AU  - Fan X
AD  - Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular 
      Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, 
      Beijing, China.
FAU - Li, Shuang
AU  - Li S
AD  - Department of Cardiac MR, Fuwai Hospital, Chinese Academy of Medical Sciences, 
      Peking Union Medical College, Beijing, China.
FAU - Sun, Wei
AU  - Sun W
AD  - Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular 
      Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, 
      Beijing, China.
FAU - Shivkumar, Kalyanam
AU  - Shivkumar K
AD  - UCLA Cardiac Arrhythmia Center, University of California-Los Angeles, UCLA Health 
      System, David Geffen School of Medicine at UCLA, Los Angeles, California, USA.
FAU - Zhao, Shihua
AU  - Zhao S
AD  - Department of Cardiac MR, Fuwai Hospital, Chinese Academy of Medical Sciences, 
      Peking Union Medical College, Beijing, China.
FAU - Lu, Minjie
AU  - Lu M
AD  - Department of Cardiac MR, Fuwai Hospital, Chinese Academy of Medical Sciences, 
      Peking Union Medical College, Beijing, China.
FAU - Yao, Yan
AU  - Yao Y
AD  - Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular 
      Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, 
      Beijing, China. Electronic address: ianyao@263.net.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20191115
PL  - England
TA  - Can J Cardiol
JT  - The Canadian journal of cardiology
JID - 8510280
SB  - IM
CIN - Can J Cardiol. 2020 Jul;36(7):1006-1008. PMID: 32249064
MH  - Adult
MH  - Cardiomyopathy, Dilated/complications/*mortality/physiopathology
MH  - China/epidemiology
MH  - Death, Sudden, Cardiac/*epidemiology/etiology
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Incidence
MH  - Male
MH  - Middle Aged
MH  - Prognosis
MH  - Retrospective Studies
MH  - Risk Assessment/*methods
MH  - Risk Factors
MH  - Ventricular Function, Left/*physiology
EDAT- 2020/04/07 06:00
MHDA- 2021/05/19 06:00
CRDT- 2020/04/07 06:00
PHST- 2019/07/28 00:00 [received]
PHST- 2019/10/31 00:00 [revised]
PHST- 2019/11/05 00:00 [accepted]
PHST- 2020/04/07 06:00 [pubmed]
PHST- 2021/05/19 06:00 [medline]
PHST- 2020/04/07 06:00 [entrez]
AID - S0828-282X(19)31433-3 [pii]
AID - 10.1016/j.cjca.2019.11.009 [doi]
PST - ppublish
SO  - Can J Cardiol. 2020 Jul;36(7):1121-1129. doi: 10.1016/j.cjca.2019.11.009. Epub 
      2019 Nov 15.