PMID- 32249611
OWN - NLM
STAT- MEDLINE
DCOM- 20200714
LR  - 20211204
IS  - 1522-1466 (Electronic)
IS  - 1522-1466 (Linking)
VI  - 318
IP  - 5
DP  - 2020 May 1
TI  - Effect of caloric restriction on phosphate metabolism and uremic vascular 
      calcification.
PG  - F1188-F1198
LID - 10.1152/ajprenal.00009.2020 [doi]
AB  - Caloric restriction (CR) is known to have multiple beneficial effects on health 
      and longevity. To study the effect of CR on phosphorus metabolism and vascular 
      calcification (VC), rats were fed normal or restricted calories (67% of normal). 
      The phosphorus content of the diets was adjusted to provide equal phosphorus 
      intake independent of the calories ingested. After 50 days of CR, rats had 
      negative phosphorus balance, lower plasma phosphorus, glucose, triglycerides, and 
      leptin, and higher adiponectin than rats fed normal calories. Uremia was induced 
      by 5/6 nephrectomy (Nx). After Nx, rats were treated with calcitriol (80 ng/kg ip 
      every other day) and high-phosphorus diets (1.2% and 1.8%). No differences in 
      aortic calcium content were observed between rats that ate normal or restricted 
      calories before Nx in either rats that received 1.2% phosphorus (11.5 +/- 1.7 vs. 
      10.9 +/- 2.1 mg/g tissue) or in rats that received 1.8% phosphorus (12.5 +/- 2.3 vs. 
      12.0 +/- 2.9 mg/g of tissue). However, mortality was significantly increased in 
      rats subjected to CR before Nx in both the 1.2% phosphorus groups (75% vs. 25%, P 
      = 0.019) and 1.8% phosphorus groups (100% vs. 45%, P < 0.001). After calcitriol 
      administration was stopped and phosphorus intake was normalized, VC regressed 
      rapidly, but no significant differences in aortic calcium were detected between 
      rats that ate normal or restricted calories during the regression phase 
      (5.7 +/- 2.7 and 5.2 +/- 1.5 mg/g tissue). In conclusion, CR did not prevent or 
      ameliorate VC and increased mortality in uremic rats.
FAU - Vidal, Angela
AU  - Vidal A
AD  - Department of Animal Medicine and Surgery, University of Cordoba, Campus 
      Universitario Rabanales, Cordoba, Spain.
AD  - Maimonides Biomedical Research Institute of Cordoba, Reina Sofia University 
      Hospital, University of Cordoba, Cordoba, Spain.
FAU - Rios, Rafael
AU  - Rios R
AD  - Department of Animal Medicine and Surgery, University of Cordoba, Campus 
      Universitario Rabanales, Cordoba, Spain.
AD  - Maimonides Biomedical Research Institute of Cordoba, Reina Sofia University 
      Hospital, University of Cordoba, Cordoba, Spain.
FAU - Pineda, Carmen
AU  - Pineda C
AUID- ORCID: 0000-0002-3664-8699
AD  - Department of Animal Medicine and Surgery, University of Cordoba, Campus 
      Universitario Rabanales, Cordoba, Spain.
AD  - Maimonides Biomedical Research Institute of Cordoba, Reina Sofia University 
      Hospital, University of Cordoba, Cordoba, Spain.
FAU - Lopez, Ignacio
AU  - Lopez I
AD  - Department of Animal Medicine and Surgery, University of Cordoba, Campus 
      Universitario Rabanales, Cordoba, Spain.
AD  - Maimonides Biomedical Research Institute of Cordoba, Reina Sofia University 
      Hospital, University of Cordoba, Cordoba, Spain.
FAU - Rodriguez, Mariano
AU  - Rodriguez M
AD  - Maimonides Biomedical Research Institute of Cordoba, Reina Sofia University 
      Hospital, University of Cordoba, Cordoba, Spain.
FAU - Aguilera-Tejero, Escolastico
AU  - Aguilera-Tejero E
AD  - Department of Animal Medicine and Surgery, University of Cordoba, Campus 
      Universitario Rabanales, Cordoba, Spain.
AD  - Maimonides Biomedical Research Institute of Cordoba, Reina Sofia University 
      Hospital, University of Cordoba, Cordoba, Spain.
FAU - Raya, Ana I
AU  - Raya AI
AD  - Department of Animal Medicine and Surgery, University of Cordoba, Campus 
      Universitario Rabanales, Cordoba, Spain.
AD  - Maimonides Biomedical Research Institute of Cordoba, Reina Sofia University 
      Hospital, University of Cordoba, Cordoba, Spain.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20200406
PL  - United States
TA  - Am J Physiol Renal Physiol
JT  - American journal of physiology. Renal physiology
JID - 100901990
RN  - 0 (Fgf23 protein, rat)
RN  - 0 (Phosphorus, Dietary)
RN  - 62031-54-3 (Fibroblast Growth Factors)
RN  - EC 3.2.1.31 (Glucuronidase)
RN  - EC 3.2.1.31 (Klotho Proteins)
RN  - FXC9231JVH (Calcitriol)
SB  - IM
MH  - Animals
MH  - Aorta/*metabolism/pathology
MH  - Aortic Diseases/etiology/metabolism/pathology/*prevention & control
MH  - Calcitriol
MH  - *Caloric Restriction
MH  - Disease Models, Animal
MH  - Disease Progression
MH  - Energy Metabolism
MH  - Female
MH  - Fibroblast Growth Factors/blood
MH  - Glucuronidase/metabolism
MH  - Kidney/*metabolism/pathology
MH  - Klotho Proteins
MH  - Nephrectomy
MH  - Phosphorus, Dietary/*metabolism
MH  - Rats, Wistar
MH  - Time Factors
MH  - Uremia/*diet therapy/etiology/metabolism
MH  - Vascular Calcification/etiology/metabolism/pathology/*prevention & control
OTO - NOTNLM
OT  - caloric restriction
OT  - rats
OT  - vascular calcification
EDAT- 2020/04/07 06:00
MHDA- 2020/07/15 06:00
CRDT- 2020/04/07 06:00
PHST- 2020/04/07 06:00 [pubmed]
PHST- 2020/07/15 06:00 [medline]
PHST- 2020/04/07 06:00 [entrez]
AID - 10.1152/ajprenal.00009.2020 [doi]
PST - ppublish
SO  - Am J Physiol Renal Physiol. 2020 May 1;318(5):F1188-F1198. doi: 
      10.1152/ajprenal.00009.2020. Epub 2020 Apr 6.