PMID- 32250947
OWN - NLM
STAT- MEDLINE
DCOM- 20210426
LR  - 20210426
IS  - 1878-0180 (Electronic)
IS  - 1878-0180 (Linking)
VI  - 106
DP  - 2020 Jun
TI  - A 3D printed porous titanium alloy rod with biogenic lamellar configuration for 
      treatment of the early-stage femoral head osteonecrosis in sheep.
PG  - 103738
LID - S1751-6161(20)30292-7 [pii]
LID - 10.1016/j.jmbbm.2020.103738 [doi]
AB  - There is no ideal implant for mechanical strut on early-stage osteonecrosis of 
      the femoral head (ONFH) after core decompression. In this study, a biogenic 
      trabecular porous titanium rod with lamellar configuration was designed and 
      fabricated using selective laser melting technique. Early-stage ONFH of sheep 
      induced by cryo-insult were dealt with core decompression combined with rod 
      insertion (Rod group) and core decompression alone (CD group) after X-ray 
      evaluation was used to assess the necrotic region one months after 
      cryo-intervention. Bone integration and ingrowth of the two groups were 
      investigated and compared. Early-stage ONFH intervened with the rod gained better 
      bone ingrowth than CD 3 and 6 months after the intervention, as evidenced by 
      radiographic, micro-CT and histological evaluation. X-ray images showed compact 
      integration between rods and peripheral bone, evidenced by no radiolucent lines 
      encircling the rods at 3 and 6 months. Micro-CT and histological images showed 
      that the new bone had grown into the centre of rods along the metal at 3 months, 
      whereas the new bone grew mainly at the periphery of the decompressive channel. 
      Micro-CT analysis show that the ratios of bone volume to total volume (BV/TV) of 
      volume of interest (VOI) in Rod group was 890.0% and 438.1% higher than CD group 
      at 3 (0.198 +/- 0.0094 VS 0.020 +/- 0.0058, p < 0.05, n = 3) and 6 (0.226 +/- 0.0166 VS 
      0.042 +/- 0.0061, p < 0.05, n = 3) months respectively. Histological analysis 
      showed that the BV/TV of VOI in Rod group was 881.0% and 413.3% higher than CD 
      group at 3 (0.206 +/- 0.0102 VS 0.021 +/- 0.0061, p < 0.05, n = 3) and 6 
      (0.231 +/- 0.0156 VS 0.045 +/- 0.0059, p < 0.05, n = 3) months respectively. The 
      mechanical tests revealed that the maximum load of Rod group was 57.6% larger 
      than CD group at 6 months (4505.25 +/- 443.86 N VS 2858.25 +/- 512.91 N, p < 0.05, 
      n = 3). These favourable short-term results can provide insight on treatment of 
      early-stage ONFH.
CI  - Copyright (c) 2020 Elsevier Ltd. All rights reserved.
FAU - Wang, Cairu
AU  - Wang C
AD  - Department of Orthopaedics, Xijing Hospital, Fourth Military Medical University, 
      Xi'an, Shaanxi, 710032, China; Department of Orthopaedics, The General Hospital 
      of Western Theater Command, Chengdu, Sichuan, 610083, China.
FAU - Xie, Qingyun
AU  - Xie Q
AD  - Department of Orthopaedics, The General Hospital of Western Theater Command, 
      Chengdu, Sichuan, 610083, China.
FAU - Yang, Lanbo
AU  - Yang L
AD  - Department of Orthopaedics, Henan Provincial Orthopaedic Hospital, Luoyang, 
      Henan, 471000, China.
FAU - Liu, Jinbiao
AU  - Liu J
AD  - Department of Orthopaedics, The General Hospital of Western Theater Command, 
      Chengdu, Sichuan, 610083, China.
FAU - Liu, Da
AU  - Liu D
AD  - Department of Orthopaedics, The General Hospital of Western Theater Command, 
      Chengdu, Sichuan, 610083, China.
FAU - Li, Zhiqiang
AU  - Li Z
AD  - Department of Orthopaedics, The General Hospital of Western Theater Command, 
      Chengdu, Sichuan, 610083, China.
FAU - Gong, Kai
AU  - Gong K
AD  - Department of Orthopaedics, The General Hospital of Western Theater Command, 
      Chengdu, Sichuan, 610083, China.
FAU - Yin, Li
AU  - Yin L
AD  - Department of Orthopaedics, The General Hospital of Western Theater Command, 
      Chengdu, Sichuan, 610083, China.
FAU - Wang, Wei
AU  - Wang W
AD  - Department of Orthopaedics, The General Hospital of Western Theater Command, 
      Chengdu, Sichuan, 610083, China.
FAU - Guo, Zheng
AU  - Guo Z
AD  - Department of Orthopaedics, Xijing Hospital, Fourth Military Medical University, 
      Xi'an, Shaanxi, 710032, China. Electronic address: guozheng@fmmu.edu.cn.
FAU - Zheng, Wei
AU  - Zheng W
AD  - Department of Orthopaedics, The General Hospital of Western Theater Command, 
      Chengdu, Sichuan, 610083, China. Electronic address: zw770880@126.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20200326
PL  - Netherlands
TA  - J Mech Behav Biomed Mater
JT  - Journal of the mechanical behavior of biomedical materials
JID - 101322406
RN  - 0 (Alloys)
RN  - D1JT611TNE (Titanium)
SB  - IM
MH  - Alloys
MH  - Animals
MH  - *Femur Head
MH  - *Femur Head Necrosis/diagnostic imaging
MH  - Porosity
MH  - Printing, Three-Dimensional
MH  - Prostheses and Implants
MH  - Sheep
MH  - *Titanium
OTO - NOTNLM
OT  - Biogenic lamellar configuration
OT  - Bone integration and ingrowth
OT  - Osteonecrosis of the femoral head
OT  - Porous titanium alloy
OT  - Sheep
COIS- Declaration of competing interest The authors have declared that no competing 
      interests exist.
EDAT- 2020/04/07 06:00
MHDA- 2021/04/27 06:00
CRDT- 2020/04/07 06:00
PHST- 2019/10/03 00:00 [received]
PHST- 2020/02/11 00:00 [revised]
PHST- 2020/03/02 00:00 [accepted]
PHST- 2020/04/07 06:00 [pubmed]
PHST- 2021/04/27 06:00 [medline]
PHST- 2020/04/07 06:00 [entrez]
AID - S1751-6161(20)30292-7 [pii]
AID - 10.1016/j.jmbbm.2020.103738 [doi]
PST - ppublish
SO  - J Mech Behav Biomed Mater. 2020 Jun;106:103738. doi: 10.1016/j.jmbbm.2020.103738. 
      Epub 2020 Mar 26.