PMID- 32252652
OWN - NLM
STAT- MEDLINE
DCOM- 20200708
LR  - 20200708
IS  - 1471-2334 (Electronic)
IS  - 1471-2334 (Linking)
VI  - 20
IP  - 1
DP  - 2020 Apr 6
TI  - Plasmodium yoelii 17XL infection modified maturation and function of dendritic 
      cells by skewing Tregs and amplificating Th17.
PG  - 266
LID - 10.1186/s12879-020-04990-z [doi]
LID - 266
AB  - BACKGROUND: Emerging data has suggested that Tregs, Th17, Th1 and Th2 are 
      correlated with early immune mechanisms by controlling Plasmodium infection. 
      Plasmodium infection appeared to impair the antigen presentation and maturation 
      of DCs, leading to attenuation of specific cellular immune response ultimately. 
      Hence, in this study, we aim to evaluate the relevance between DCs and Tregs/Th17 
      populations in the process and outcomes of infection with Plasmodium yoelii 17XL 
      (P.y17XL). METHODS: DCs detection/analysis dynamically was performed by Tregs 
      depletion or Th17 neutralization in P.y17XL infected BALB/c mice via flow 
      cytometry. Then the levels of cytokines production were detected using 
      enzyme-linked mmunosorbent assay (ELISA). RESULTS: Our results indicated that 
      Tregs depletion or Th17 neutralization in BALB/c mice infected with P.y17XL 
      significantly up-regulated the percentages of mDC and pDC, increased the 
      expressions of major histocompatibility complex (MHC) class II, CD80, CD86 on DCs 
      and the levels of IL-10/IL-12 secreted by DCs, indicating that abnormal 
      amplification of Tregs or Th17 may damage the maturation and function of DCs 
      during the early stage of malaria infection. Interestingly, we also found that 
      the abnormal amplification of Th17, as well as Tregs, could inhibit the 
      maturation of DCs. CONCLUSIONS: Tregs skewing or Th17 amplification during the 
      early stage of malaria infection may inhibit the maturation and function of DCs 
      by modifying the subsets of DCs, expressions of surface molecules on DCs and 
      secretion mode of cytokines.
FAU - Chen, Guang
AU  - Chen G
AD  - Department of Basic Medical Sciences, Taizhou University Hospital, Taizhou 
      University, No 1139 Shifu Road, Jiaojiang District, Taizhou, 318000, China. 
      misschenguang75@163.com.
FAU - Du, Ji-Wei
AU  - Du JW
AD  - Nursing Department, Xiang'An Hospital, Xiamen University, No 2000, Xian'an East 
      Road, Xiang'an District, Xiamen, 361005, China.
FAU - Nie, Qing
AU  - Nie Q
AD  - Weifang Centers for Disease Control and Prevention, No 4801 Huixian Road, Gaoxin 
      District, Shandong Province, Weifang, 261061, China.
FAU - Du, Yun-Ting
AU  - Du YT
AD  - Department of Laboratory Medicine, Cancer Hospital of China Medical University, 
      Liaoning Cancer Hospital & Institute, No 44, Xiaoheyan Road, Dadong District, 
      Shenyang, 110042, China.
FAU - Liu, Shuang-Chun
AU  - Liu SC
AD  - Municipal Hospital Affiliated to Medical School of Taizhou University, No 381, 
      Zhongshan East Road, Jiaojiang District, Taizhou, 318000, China.
FAU - Liu, De-Hui
AU  - Liu DH
AD  - Weifang Centers for Disease Control and Prevention, No 4801 Huixian Road, Gaoxin 
      District, Shandong Province, Weifang, 261061, China.
FAU - Zhang, Hui-Ming
AU  - Zhang HM
AD  - College of Basic Medical Sciences, Jiamusi University, No 148 Xuefu Street, 
      Jiamusi, 154007, China.
FAU - Wang, Fang-Fang
AU  - Wang FF
AD  - College of Basic Medical Sciences, Jiamusi University, No 148 Xuefu Street, 
      Jiamusi, 154007, China.
LA  - eng
GR  - 81101278/Innovative Research Group Project of the National Natural Science 
      Foundation of China (CN)/
GR  - ZD2017020/Innovative Research Group Project of the National Natural Science 
      Foundation of China (CN)/
GR  - 20180540019/doctor star-up foundation of Liaoning Province/
GR  - 2017KEYLAB-03/Guangdong Provincial Key Laboratory of Prevention and Control for 
      Severe Clinical Animal Diseases (CN)/
PT  - Journal Article
DEP - 20200406
PL  - England
TA  - BMC Infect Dis
JT  - BMC infectious diseases
JID - 100968551
RN  - 0 (Cytokines)
SB  - IM
MH  - Animals
MH  - Cytokines/metabolism
MH  - Dendritic Cells/*immunology/parasitology
MH  - Female
MH  - Host-Parasite Interactions
MH  - Immunity, Cellular
MH  - Malaria/*immunology/parasitology
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Plasmodium yoelii/*pathogenicity
MH  - T-Lymphocytes, Regulatory/immunology/parasitology/*pathology
MH  - Th1 Cells/immunology
MH  - Th17 Cells/*parasitology/pathology
PMC - PMC7132900
OTO - NOTNLM
OT  - Dendritic cells
OT  - Malaria infection
OT  - Plasmodium yoelii 17XL
OT  - Th17
OT  - Tregs
COIS- The authors declare that they have no conflicts of interest in relation to this 
      article.
EDAT- 2020/04/08 06:00
MHDA- 2020/07/09 06:00
PMCR- 2020/04/06
CRDT- 2020/04/08 06:00
PHST- 2019/07/25 00:00 [received]
PHST- 2020/03/25 00:00 [accepted]
PHST- 2020/04/08 06:00 [entrez]
PHST- 2020/04/08 06:00 [pubmed]
PHST- 2020/07/09 06:00 [medline]
PHST- 2020/04/06 00:00 [pmc-release]
AID - 10.1186/s12879-020-04990-z [pii]
AID - 4990 [pii]
AID - 10.1186/s12879-020-04990-z [doi]
PST - epublish
SO  - BMC Infect Dis. 2020 Apr 6;20(1):266. doi: 10.1186/s12879-020-04990-z.