PMID- 32253138
OWN - NLM
STAT- MEDLINE
DCOM- 20210609
LR  - 20210609
IS  - 1877-0568 (Electronic)
IS  - 1877-0568 (Linking)
VI  - 106
IP  - 3
DP  - 2020 May
TI  - Role of intra-wound powdered vancomycin in primary total knee arthroplasty.
PG  - 417-420
LID - S1877-0568(20)30054-2 [pii]
LID - 10.1016/j.otsr.2020.01.007 [doi]
AB  - BACKGROUND: No study has evaluated the effect of topical powdered vancomycin in 
      patients undergoing primary total knee arthroplasty (TKA). The goal of this study 
      is to determine if this method reduces postoperative infection rates following 
      primary TKA. PATIENTS AND METHODS: This retrospective study reviewed 855 
      consecutive patients undergoing TKA. The first 418 patients, who did not receive 
      topical vancomycin, were grouped into the control group and the subsequent 437 
      patients, who received powdered vancomycin applied to the target joint prior to 
      wound closure, were grouped into the treatment group. RESULTS: The control group 
      was found to have 18 infectious complications (4.3%) compared with 6 (1.4%) in 
      the treatment group, which differed significantly (p<0.05). When comparing the 
      rates of infectious complications independently, there was no significant 
      difference in the rate of superficial infection (3.1% vs. 1.4%; p>0.05), while 
      the difference in prevalence of periprosthetic joint infection (PJI) was 
      statistically significant (1.2% vs. 0; p<0.05). No serious adverse events (AEs) 
      occurred. DISCUSSION: Topical application of powdered vancomycin may present a 
      reasonable means of decreasing the risk of infectious complications following 
      TKA. There were no serious AEs associated with topical vancomycin. Further 
      research is needed to focus on its long-term efficacy and safety. LEVEL OF 
      EVIDENCE: III, retrospective, cohort study.
CI  - Copyright (c) 2020 Elsevier Masson SAS. All rights reserved.
FAU - Xu, Xinxian
AU  - Xu X
AD  - The Osteopathy Department, the Second Affiliated Hospital and Yuying Children(')s 
      Hospital of Wenzhou Medical University, Wenzhou, China.
FAU - Zhang, Xue
AU  - Zhang X
AD  - The Department of Operation room, the Second Affiliated Hospital and Yuying 
      Children(')s Hospital of Wenzhou Medical University, Wenzhou, China.
FAU - Zhang, Yu
AU  - Zhang Y
AD  - The Osteopathy Department, the Second Affiliated Hospital and Yuying Children(')s 
      Hospital of Wenzhou Medical University, Wenzhou, China.
FAU - Chen, Chengwang
AU  - Chen C
AD  - The Osteopathy Department, the Second Affiliated Hospital and Yuying Children(')s 
      Hospital of Wenzhou Medical University, Wenzhou, China.
FAU - Yu, Huachen
AU  - Yu H
AD  - The Osteopathy Department, the Second Affiliated Hospital and Yuying Children(')s 
      Hospital of Wenzhou Medical University, Wenzhou, China.
FAU - Xue, Enxing
AU  - Xue E
AD  - The Osteopathy Department, the Second Affiliated Hospital and Yuying Children(')s 
      Hospital of Wenzhou Medical University, Wenzhou, China. Electronic address: 
      xueenxing3@163.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20200403
PL  - France
TA  - Orthop Traumatol Surg Res
JT  - Orthopaedics & traumatology, surgery & research : OTSR
JID - 101494830
RN  - 0 (Powders)
RN  - 6Q205EH1VU (Vancomycin)
SB  - IM
MH  - *Arthroplasty, Replacement, Knee/adverse effects
MH  - Cohort Studies
MH  - Humans
MH  - Powders
MH  - *Prosthesis-Related Infections/epidemiology/prevention & control
MH  - Retrospective Studies
MH  - Vancomycin
OTO - NOTNLM
OT  - Periprosthetic joint infection (PJI)
OT  - Superficial infection
OT  - Topical powdered vancomycin
OT  - Total knee arthroplasty (TKA)
OT  - Wound complications
EDAT- 2020/04/08 06:00
MHDA- 2021/06/10 06:00
CRDT- 2020/04/08 06:00
PHST- 2019/08/31 00:00 [received]
PHST- 2019/12/20 00:00 [revised]
PHST- 2020/01/05 00:00 [accepted]
PHST- 2020/04/08 06:00 [pubmed]
PHST- 2021/06/10 06:00 [medline]
PHST- 2020/04/08 06:00 [entrez]
AID - S1877-0568(20)30054-2 [pii]
AID - 10.1016/j.otsr.2020.01.007 [doi]
PST - ppublish
SO  - Orthop Traumatol Surg Res. 2020 May;106(3):417-420. doi: 
      10.1016/j.otsr.2020.01.007. Epub 2020 Apr 3.