PMID- 32253395
OWN - NLM
STAT- MEDLINE
DCOM- 20210430
LR  - 20210430
IS  - 2050-7518 (Electronic)
IS  - 2050-750X (Linking)
VI  - 8
IP  - 18
DP  - 2020 May 14
TI  - A novel elastic and controlled-release poly(ether-ester-urethane)urea scaffold 
      for cartilage regeneration.
PG  - 4106-4121
LID - 10.1039/c9tb02754h [doi]
AB  - In the tissue engineering of cartilage, scaffolds with appropriate elasticity and 
      controlled-release properties are essential. Herein, we synthesized a 
      poly(ether-ester-urethane)urea scaffold with a pendant amino group (PEEUUN) 
      through a de-protection process from PEEUU-Boc polymers and grafted kartogenin 
      (KGN) onto the PEEUUN scaffolds (PEEUUN-KGN). Characterization, performance 
      tests, scaffold biocompatibility analysis, and chondrogenesis evaluation both in 
      vitro and in vivo were conducted. The results revealed that the PEEUUN-KGN 
      scaffolds were degradable and three-dimensional (3D) with interconnected pores, 
      and possessed good elasticity, as well as excellent cytocompatibility. Meanwhile, 
      KGN on the PEEUUN-KGN scaffolds underwent stable sustained release for a long 
      time and promoted human umbilical cord mesenchymal stem cells (HUCMSCs) to 
      differentiate into chondrocytes in vitro, thus enhancing cartilage regeneration 
      in vivo. In conclusion, the present PEEUUN-KGN scaffolds would have application 
      potential for cartilage tissue engineering.
FAU - Chen, Chang'an
AU  - Chen C
AD  - Department of Sports Medicine, Shanghai Jiao Tong University Affiliated Sixth 
      People's Hospital, Shanghai 200233, People's Republic of China. 
      jzzhao@sjtu.edu.cn xyyan@sjtu.edu.cn zhutonghe@sjtu.edu.cn.
FAU - Huang, Kai
AU  - Huang K
FAU - Zhu, Jingjing
AU  - Zhu J
FAU - Bi, Yikang
AU  - Bi Y
FAU - Wang, Liren
AU  - Wang L
FAU - Jiang, Jia
AU  - Jiang J
FAU - Zhu, Tonghe
AU  - Zhu T
FAU - Yan, Xiaoyu
AU  - Yan X
FAU - Zhao, Jinzhong
AU  - Zhao J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20200407
PL  - England
TA  - J Mater Chem B
JT  - Journal of materials chemistry. B
JID - 101598493
RN  - 0 (Biocompatible Materials)
RN  - 0 (Delayed-Action Preparations)
RN  - 0 (Esters)
RN  - 0 (Ethers)
RN  - 0 (Polymers)
RN  - 3IN71E75Z5 (Urethane)
RN  - 8W8T17847W (Urea)
SB  - IM
MH  - Animals
MH  - Biocompatible Materials/chemical synthesis/*chemistry
MH  - Cells, Cultured
MH  - Delayed-Action Preparations
MH  - Elastic Cartilage/*chemistry
MH  - Esters/chemical synthesis/chemistry
MH  - Ethers/chemical synthesis/chemistry
MH  - Humans
MH  - Molecular Structure
MH  - Particle Size
MH  - Polymers/chemical synthesis/*chemistry
MH  - Porosity
MH  - Rabbits
MH  - Surface Properties
MH  - *Tissue Engineering
MH  - Tissue Scaffolds/*chemistry
MH  - Urea/analogs & derivatives/*chemistry
MH  - Urethane/chemical synthesis/chemistry
EDAT- 2020/04/08 06:00
MHDA- 2021/05/01 06:00
CRDT- 2020/04/08 06:00
PHST- 2020/04/08 06:00 [pubmed]
PHST- 2021/05/01 06:00 [medline]
PHST- 2020/04/08 06:00 [entrez]
AID - 10.1039/c9tb02754h [doi]
PST - ppublish
SO  - J Mater Chem B. 2020 May 14;8(18):4106-4121. doi: 10.1039/c9tb02754h. Epub 2020 
      Apr 7.