PMID- 32255000
OWN - NLM
STAT- MEDLINE
DCOM- 20200817
LR  - 20200817
IS  - 2050-7518 (Electronic)
IS  - 2050-750X (Linking)
VI  - 7
IP  - 16
DP  - 2019 Apr 28
TI  - An injectable nanocomposite hydrogel co-constructed with gold nanorods and 
      paclitaxel-loaded nanoparticles for local chemo-photothermal synergetic cancer 
      therapy.
PG  - 2667-2677
LID - 10.1039/c9tb00120d [doi]
AB  - The precise locoregional co-delivery of multi-agents is an attractive strategy 
      for combination cancer therapy, with the imperative requirement of an ideal 
      injectable hydrogel platform with immense adaptability and multicomponent 
      compatibility to achieve synergetic therapeutic efficiency. Herein, the methoxy 
      poly(ethylene 
      glycol)-b-poly(epsilon-caprolactone-co-1,4,8-trioxa[4.6]spiro-9-undecanone) (mPECT) 
      diblock copolymer was empolyed to prepare mPECT-modified gold nanorods 
      (AuNR-PECT) and paclitaxel-loaded mPECT nanoparticles (PTX/mPECT NPs). Then, an 
      injectable nanocomposite hydrogel ((AuNR/PTX)mPECT(gel)) was fabricated by the 
      host-guest inclusion between AuNR-PECT, PTX/mPECT NPs and alpha-cyclodextrin. A 
      single local injection of (AuNR/PTX)mPECT(gel) could deposit abundant PTX/mPECT 
      NPs (20% w/w) and AuNRs at the target location, which then sustainedly released 
      PTX/mPECT NPs at a constant rate for two weeks and exhibited outstanding 
      photothermal effects by near-infrared radiation. As a result, complete tumor 
      regression after peritumoral injection of (AuNR/PTX)mPECT(gel) and effective 
      inhibition of tumor recurrence after injection of (AuNR/PTX)mPECT(gel) in the 
      postoperative cavity were observed in breast cancer mouse models; this can be 
      attributed to the in situ synergetic chemo-photothermal anticancer efficiencies 
      of AuNR and the PTX/mPECT NPs. Remarkably, this injectable hydrogel platform 
      constructed by supramolecular assembly of multi-nanoagents can be facilely 
      extended to local combination therapies of different therapeutic agents.
FAU - Liu, Meiyan
AU  - Liu M
AD  - Department of Polymer Science and Engineering, Key Laboratory of Systems 
      Bioengineering (Ministry of Education), School of Chemical Engineering and 
      Technology, Tianjin University, Tianjin 300072, China. ajdong@tju.edu.cn.
FAU - Huang, Pingsheng
AU  - Huang P
FAU - Wang, Weiwei
AU  - Wang W
FAU - Feng, Zujian
AU  - Feng Z
FAU - Zhang, Jianhua
AU  - Zhang J
FAU - Deng, Liandong
AU  - Deng L
FAU - Dong, Anjie
AU  - Dong A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20190322
PL  - England
TA  - J Mater Chem B
JT  - Journal of materials chemistry. B
JID - 101598493
RN  - 0 (Antineoplastic Agents, Phytogenic)
RN  - 0 (Hydrogels)
RN  - 0 (Polyesters)
RN  - 3WJQ0SDW1A (Polyethylene Glycols)
RN  - 7440-57-5 (Gold)
RN  - 9004-74-4 (monomethoxypolyethylene glycol)
RN  - P88XT4IS4D (Paclitaxel)
SB  - IM
MH  - Animals
MH  - Antineoplastic Agents, Phytogenic/*administration & dosage/chemistry
MH  - Cell Line, Tumor
MH  - Female
MH  - Gold/administration & dosage/chemistry
MH  - Hydrogels/*administration & dosage/chemistry
MH  - Injections
MH  - Mammary Neoplasms, Experimental/*drug therapy
MH  - Mice, Inbred BALB C
MH  - Nanocomposites/*administration & dosage/chemistry
MH  - Nanoparticles/administration & dosage/chemistry
MH  - Nanotubes/chemistry
MH  - Paclitaxel/*administration & dosage/chemistry
MH  - Photochemotherapy
MH  - Polyesters/administration & dosage/chemistry
MH  - Polyethylene Glycols/administration & dosage/chemistry
EDAT- 2020/04/08 06:00
MHDA- 2020/08/18 06:00
CRDT- 2020/04/08 06:00
PHST- 2020/04/08 06:00 [entrez]
PHST- 2020/04/08 06:00 [pubmed]
PHST- 2020/08/18 06:00 [medline]
AID - 10.1039/c9tb00120d [doi]
PST - ppublish
SO  - J Mater Chem B. 2019 Apr 28;7(16):2667-2677. doi: 10.1039/c9tb00120d. Epub 2019 
      Mar 22.