PMID- 32256672
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220413
IS  - 1743-7075 (Print)
IS  - 1743-7075 (Electronic)
IS  - 1743-7075 (Linking)
VI  - 17
DP  - 2020
TI  - Anorexic and metabolic effect of jojoba: potential treatment against metabolic 
      syndrome and hepatic complications.
PG  - 24
LID - 10.1186/s12986-020-00441-3 [doi]
LID - 24
AB  - BACKGROUND: Evaluation of the action of various traditional plants to treat 
      metabolic syndrome are strongly studied. In our study, we investigated the effect 
      of the Tunisian jojoba seed on a metabolic syndrome induced in rat by the High 
      Fat diet and High Fructose (HFHF) and its renal and hepatic complications. 
      METHODS: The rats were fed with HFHF or Normal Diet (ND) for a period of 8 weeks. 
      After that, a switch from HFHF to ND or Normal Diet Jojoba (NDJ),(jojoba diet 
      approach) or High Fat and High Fructose and Jojoba diet (HFHFJ) (nutraceutical 
      approach) has been done. Metabolic disorder was evaluated by measuring the 
      fasting body weight, glycemia and C-peptide and leptin. Oxidative stress 
      parameters like ThioBarbituric Acid Reactive Substances (TBARS) and Total 
      Antioxidant Capacity (TAOC) were analyzed in the plasma and renal and hepatic 
      function were determined by the measure of creatinine and alanine transferase 
      (ALT) respectively. Histological analysis was performed on the liver, kidney and 
      pancreas. RESULTS: HFHF diet exhibited characteristics of metabolic syndrome 
      presented by insulin resistance, hyperinsulinemia, hyperleptinemia, fat mass with 
      hepatic steatosis and renal disorder. HFHF diet was associated with oxidative 
      stress (OS) presented by an increase in TBARS and a decrease in TAOC. Adding 
      jojoba seeds to HFHF rat group diet induced a decrease in body weight, fat mass 
      (58 and 41%), insulin resistance (59 and 56%), oxidative stress (60 and 41%), 
      liver steatosis (from a score = 3 to a score = 0) and renal complications (25 and 
      42%). This effect was emphasized with diet approach. CONCLUSION: The results 
      demonstrated the beneficial effect of jojoba against metabolic syndrome and 
      oxidative stress, suggesting that jojoba could be used in the prevention and 
      treatment of metabolic syndrome.
CI  - (c) The Author(s) 2020.
FAU - Belhadj, Sahla
AU  - Belhadj S
AD  - 1UMR DIATHEC, EA 7294, Federation of Traditional Medicine of Strasbourg (FMTS), 
      University of Strasbourg, Strasbourg, France. GRID: grid.11843.3f. ISNI: 0000 
      0001 2157 9291
FAU - Dal, Stephanie
AU  - Dal S
AD  - 1UMR DIATHEC, EA 7294, Federation of Traditional Medicine of Strasbourg (FMTS), 
      University of Strasbourg, Strasbourg, France. GRID: grid.11843.3f. ISNI: 0000 
      0001 2157 9291
FAU - Khaskhoussi, Fakhreddine
AU  - Khaskhoussi F
AD  - AGRO-CRC, Al Amine Al Abbassi Street, 1002 Tunis, Tunisia.
FAU - Maillard-Pedracini, Elisa
AU  - Maillard-Pedracini E
AD  - 1UMR DIATHEC, EA 7294, Federation of Traditional Medicine of Strasbourg (FMTS), 
      University of Strasbourg, Strasbourg, France. GRID: grid.11843.3f. ISNI: 0000 
      0001 2157 9291
FAU - Hentati, Olfa
AU  - Hentati O
AD  - 3Institut Superieur de Biotechnologie de Sfax, Universite de Sfax, Route de 
      Soukra, Km 4, BP 1175, 3038 Sfax, Tunisia. GRID: grid.412124.0. ISNI: 0000 0001 
      2323 5644
AD  - 4Laboratoire Genie Environnement et Ecotechnologie, Ecole Nationale d'Ingenieurs 
      de Sfax (LGEET LR16ES19-ENIS), Universite de Sfax, Route de Soukra, Km 4, BP 
      1173, 3038 Sfax, Tunisia. GRID: grid.412124.0. ISNI: 0000 0001 2323 5644
FAU - Sigrist, Severine
AU  - Sigrist S
AD  - 1UMR DIATHEC, EA 7294, Federation of Traditional Medicine of Strasbourg (FMTS), 
      University of Strasbourg, Strasbourg, France. GRID: grid.11843.3f. ISNI: 0000 
      0001 2157 9291
LA  - eng
PT  - Journal Article
DEP - 20200330
PL  - England
TA  - Nutr Metab (Lond)
JT  - Nutrition & metabolism
JID - 101231644
PMC - PMC7106724
OTO - NOTNLM
OT  - Hight fat Hight fat diet
OT  - Jojoba
OT  - Metabolic syndrome
OT  - Oxidative stress
COIS- Competing interestsThe authors declare that they have no competing interests
EDAT- 2020/04/08 06:00
MHDA- 2020/04/08 06:01
PMCR- 2020/03/30
CRDT- 2020/04/08 06:00
PHST- 2019/07/16 00:00 [received]
PHST- 2020/03/12 00:00 [accepted]
PHST- 2020/04/08 06:00 [entrez]
PHST- 2020/04/08 06:00 [pubmed]
PHST- 2020/04/08 06:01 [medline]
PHST- 2020/03/30 00:00 [pmc-release]
AID - 441 [pii]
AID - 10.1186/s12986-020-00441-3 [doi]
PST - epublish
SO  - Nutr Metab (Lond). 2020 Mar 30;17:24. doi: 10.1186/s12986-020-00441-3. 
      eCollection 2020.