PMID- 32256753
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231113
IS  - 1792-0981 (Print)
IS  - 1792-1015 (Electronic)
IS  - 1792-0981 (Linking)
VI  - 19
IP  - 4
DP  - 2020 Apr
TI  - Decreased basal and stimulated salivary parameters by histopathological lesions 
      and secretory dysfunction of parotid and submandibular glands in rats with type 2 
      diabetes.
PG  - 2707-2719
LID - 10.3892/etm.2020.8505 [doi]
AB  - Patients with type 2 diabetes mellitus (T2DM) present with dry mouth, polydipsia 
      and taste impairment due to salivary secretion disorder. However, the underlying 
      functional mechanism of T2DM remains unknown. The present study found that T2DM 
      rats had significantly lower salivary flow rate and salivary alpha amylase 
      activity, and attenuated salivary secretion responses to acid stimulation 
      compared with control rats. Histopathological observation found that T2DM rats 
      had inflammatory cell infiltration with increased expressions of IL-6 and TNF-alpha, 
      oxidative stress, including decreased total superoxide dismutase activity and 
      increased malondialdehyde content, and decreased expressions of beta1 adrenergic 
      receptor, cholinergic receptor, aquaporin-5 and protein kinase A in salivary 
      glands, in particular the parotid gland. These results indicated that parotid 
      gland impairment was more severe compared with submandibular gland impairment. 
      Reduced salivary secretion may be associated with histopathological lesions and 
      decreased regulation in secretory pathways in salivary glands.
CI  - Copyright: (c) Chen et al.
FAU - Chen, Si-Yu
AU  - Chen SY
AD  - Department of Biochemistry and Molecular Biology, School of Life Sciences and 
      Biopharmaceutics, Guangdong Pharmaceutical University, Guangzhou, Guangdong 
      510006, P.R. China.
FAU - Wang, Ying
AU  - Wang Y
AD  - Department of Biochemistry and Molecular Biology, School of Life Sciences and 
      Biopharmaceutics, Guangdong Pharmaceutical University, Guangzhou, Guangdong 
      510006, P.R. China.
FAU - Zhang, Chun-Lei
AU  - Zhang CL
AD  - Department of Stomatology, The First Affiliated Hospital of Jinan University, 
      Guangzhou, Guangdong 510632, P.R. China.
FAU - Yang, Ze-Min
AU  - Yang ZM
AD  - Department of Biochemistry and Molecular Biology, School of Life Sciences and 
      Biopharmaceutics, Guangdong Pharmaceutical University, Guangzhou, Guangdong 
      510006, P.R. China.
LA  - eng
PT  - Journal Article
DEP - 20200210
PL  - Greece
TA  - Exp Ther Med
JT  - Experimental and therapeutic medicine
JID - 101531947
PMC - PMC7086285
OTO - NOTNLM
OT  - histopathological lesion
OT  - parotid glands
OT  - salivary parameters
OT  - secretory dysfunction
OT  - submandibular gland
OT  - type 2 diabetes mellitus
EDAT- 2020/04/08 06:00
MHDA- 2020/04/08 06:01
PMCR- 2020/02/10
CRDT- 2020/04/08 06:00
PHST- 2019/05/24 00:00 [received]
PHST- 2020/01/17 00:00 [accepted]
PHST- 2020/04/08 06:00 [entrez]
PHST- 2020/04/08 06:00 [pubmed]
PHST- 2020/04/08 06:01 [medline]
PHST- 2020/02/10 00:00 [pmc-release]
AID - ETM-0-0-8505 [pii]
AID - 10.3892/etm.2020.8505 [doi]
PST - ppublish
SO  - Exp Ther Med. 2020 Apr;19(4):2707-2719. doi: 10.3892/etm.2020.8505. Epub 2020 Feb 
      10.