PMID- 32256794
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200928
IS  - 1792-0981 (Print)
IS  - 1792-1015 (Electronic)
IS  - 1792-0981 (Linking)
VI  - 19
IP  - 4
DP  - 2020 Apr
TI  - Effectiveness and safety of pulsatile intravenous insulin therapy for the 
      improvement of respiratory quotient in Chinese patients with diabetes mellitus.
PG  - 3069-3075
LID - 10.3892/etm.2020.8563 [doi]
AB  - Pulsatile intravenous insulin therapy (PIVIT) is a means of imitating naturally 
      occurring insulin pulses artificially. It is thought to improve carbohydrate 
      metabolism, which can be assessed using the respiratory quotient (RQ). The aim of 
      this present study was to assess the efficacy and safety of PIVIT for the 
      improvement of RQ in Chinese patients with diabetes mellitus (DM). This 12-week, 
      multi-center, prospective, randomized, open-label, parallel-group study involved 
      110 DM patients (both type 1 and type 2) whose RQ was <0.8. Of these, 53 patients 
      formed the control group, in which standard anti-diabetic therapy was maintained, 
      and 54 patients formed the treatment group, which underwent weekly PIVIT in 
      addition to the administration of standard anti-diabetic therapy. RQ was 
      evaluated monthly in control subjects, and before and after every PIVIT treatment 
      in the treatment group. After weekly PIVIT for 12 weeks, the mean RQ increased 
      from 0.70 to 0.90 in the treatment group, but did not change in the control 
      group. The percentage of subjects reporting adverse events (AEs) was 31.5% 
      (17/54) in the treatment group and 9.43% (5/53) in the control group (P=0.0053). 
      The most frequently reported AE (by 12 subjects) was a gastroenteric reaction 
      when these individuals were receiving 50% glucose during the PIVIT treatment. The 
      majority of AEs were mild and did not interfere with the ongoing treatment. Thus, 
      PIVIT can be viewed as tolerated and effective for the improvement of RQ in 
      Chinese DM patients. This study was retrospectively registered with the Chinese 
      Clinical Trial Registry (http://www.chictr.org.cn) on November 13th 2019 
      (registration no. ChiCTR1900027510).
CI  - Copyright: (c) Gu et al.
FAU - Gu, Nan
AU  - Gu N
AD  - Department of Endocrinology, Peking University First Hospital, Beijing 100034, 
      P.R. China.
FAU - Dong, Aimei
AU  - Dong A
AD  - Department of Endocrinology, Peking University First Hospital, Beijing 100034, 
      P.R. China.
FAU - Gao, Lei
AU  - Gao L
AD  - Institute of Clinical Pharmacology, Peking University First Hospital, Beijing 
      100034, P.R. China.
FAU - Xie, Chenying
AU  - Xie C
AD  - Department of Endocrinology, Peking University First Hospital, Beijing 100034, 
      P.R. China.
FAU - Hou, Peiyi
AU  - Hou P
AD  - Department of Endocrinology, Peking University First Hospital, Beijing 100034, 
      P.R. China.
FAU - Wang, Wenbo
AU  - Wang W
AD  - Department of Endocrinology, Peking University Shougang Hospital, Beijing 100144, 
      P.R. China.
FAU - Zhu, Sainan
AU  - Zhu S
AD  - Department of Biostatistics, Peking University First Hospital, Beijing 100034, 
      P.R. China.
FAU - Yao, Chen
AU  - Yao C
AD  - Department of Biostatistics, Peking University First Hospital, Beijing 100034, 
      P.R. China.
FAU - Zhang, Junqing
AU  - Zhang J
AD  - Department of Endocrinology, Peking University First Hospital, Beijing 100034, 
      P.R. China.
FAU - Guo, Xiaohui
AU  - Guo X
AD  - Department of Endocrinology, Peking University First Hospital, Beijing 100034, 
      P.R. China.
LA  - eng
PT  - Journal Article
DEP - 20200227
PL  - Greece
TA  - Exp Ther Med
JT  - Experimental and therapeutic medicine
JID - 101531947
PMC - PMC7086298
OTO - NOTNLM
OT  - diabetes
OT  - pulsatile intravenous insulin therapy
OT  - respiratory quotient
EDAT- 2020/04/08 06:00
MHDA- 2020/04/08 06:01
PMCR- 2020/02/27
CRDT- 2020/04/08 06:00
PHST- 2019/05/31 00:00 [received]
PHST- 2019/12/20 00:00 [accepted]
PHST- 2020/04/08 06:00 [entrez]
PHST- 2020/04/08 06:00 [pubmed]
PHST- 2020/04/08 06:01 [medline]
PHST- 2020/02/27 00:00 [pmc-release]
AID - ETM-0-0-8563 [pii]
AID - 10.3892/etm.2020.8563 [doi]
PST - ppublish
SO  - Exp Ther Med. 2020 Apr;19(4):3069-3075. doi: 10.3892/etm.2020.8563. Epub 2020 Feb 
      27.