PMID- 32257549
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200928
IS  - 2152-5250 (Print)
IS  - 2152-5250 (Electronic)
IS  - 2152-5250 (Linking)
VI  - 11
IP  - 2
DP  - 2020 Apr
TI  - Alteration in the Function and Expression of SLC and ABC Transporters in the 
      Neurovascular Unit in Alzheimer's Disease and the Clinical Significance.
PG  - 390-404
LID - 10.14336/AD.2019.0519 [doi]
AB  - The neurovascular unit (NVU) plays an important role in maintaining the function 
      of the central nervous system (CNS). Emerging evidence has indicated that the NVU 
      changes function and molecules at the early stage of Alzheimer's disease (AD), 
      which initiates multiple pathways of neurodegeneration. Cell types in the NVU 
      have become attractive targets in the interventional treatment of AD. The NVU 
      transportation system contains a variety of proteins involved in compound 
      transport and neurotransmission. Brain transporters can be classified as members 
      of the solute carrier (SLC) and ATP-binding cassette (ABC) families in the NVU. 
      Moreover, the transporters can regulate both endogenous toxins, including 
      amyloid-beta (Abeta) and xenobiotic homeostasis, in the brains of AD patients. 
      Genome-wide association studies (GWAS) have identified some transporter gene 
      variants as susceptibility loci for late-onset AD. Therefore, the present study 
      summarizes changes in blood-brain barrier (BBB) permeability in AD, identifies 
      the location of SLC and ABC transporters in the brain and focuses on major SLC 
      and ABC transporters that contribute to AD pathology.
CI  - Copyright: (c) 2020 Jia et al.
FAU - Jia, Yongming
AU  - Jia Y
AD  - 1Department of Neuropharmacology, College of Pharmacy, Qiqihar Medical 
      University, Qiqihar, China.
FAU - Wang, Na
AU  - Wang N
AD  - 2Department of Pathophysiology, Basic Medical Science College, Qiqihar Medical 
      University, Qiqihar, China.
FAU - Zhang, Yingbo
AU  - Zhang Y
AD  - 3College of Pathology, Qiqihar Medical University, Qiqihar, China.
FAU - Xue, Di
AU  - Xue D
AD  - 1Department of Neuropharmacology, College of Pharmacy, Qiqihar Medical 
      University, Qiqihar, China.
FAU - Lou, Haoming
AU  - Lou H
AD  - 4Department of Medicinal Chemistry and Chemistry of Chinese Materia Medica, 
      School of Pharmacy, Changchun University of Chinese Medicine, Changchun, China.
FAU - Liu, Xuewei
AU  - Liu X
AD  - 1Department of Neuropharmacology, College of Pharmacy, Qiqihar Medical 
      University, Qiqihar, China.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20200309
PL  - United States
TA  - Aging Dis
JT  - Aging and disease
JID - 101540533
PMC - PMC7069460
OTO - NOTNLM
OT  - ATP-binding cassette transporters
OT  - Alzheimer's disease
OT  - blood-brain barrier
OT  - solute carrier
COIS- Conflicts of Interest The authors declare no conflict of interest.
EDAT- 2020/04/08 06:00
MHDA- 2020/04/08 06:01
PMCR- 2020/04/01
CRDT- 2020/04/08 06:00
PHST- 2019/02/19 00:00 [received]
PHST- 2019/05/19 00:00 [accepted]
PHST- 2020/04/08 06:00 [entrez]
PHST- 2020/04/08 06:00 [pubmed]
PHST- 2020/04/08 06:01 [medline]
PHST- 2020/04/01 00:00 [pmc-release]
AID - ad-11-2-390 [pii]
AID - 10.14336/AD.2019.0519 [doi]
PST - epublish
SO  - Aging Dis. 2020 Mar 9;11(2):390-404. doi: 10.14336/AD.2019.0519. eCollection 2020 
      Apr.