PMID- 32258022
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220413
IS  - 2296-4681 (Print)
IS  - 2296-4657 (Electronic)
IS  - 2296-4657 (Linking)
VI  - 6
IP  - 2
DP  - 2020 Mar
TI  - Mucoepidermoid Carcinoma of the Lacrimal Sac: Clinical-Pathologic Analysis, 
      Including Molecular Genetics.
PG  - 138-144
LID - 10.1159/000502699 [doi]
AB  - PURPOSE: The aim of this study was to assess whether mucoepidermoid carcinoma of 
      the lacrimal sac is a counterpart of CRTC1/3-MAML2 gene fusion-related salivary 
      gland mucoepidermoid carcinoma. METHODS: In this retrospective observational case 
      series, pathology records were searched for all cases of lacrimal sac 
      mucoepidermoid carcinoma diagnosed between 1990 and 2018. Data collected included 
      demographics, clinical findings, management, and follow-up. Pathologic parameters 
      assessed included tumor morphology, immunohistochemistry, and MAML2 and EGFR 
      fluorescence in situ hybridization (FISH) studies. RESULTS: Six patients with 
      mucoepidermoid carcinoma of the lacrimal sac, 5 males and 1 female, with a median 
      age of 63 years (range 24-66) were identified. Five tumors were managed with 
      radical resection and 1 patient underwent orbital exenteration. None of the 
      patients developed recurrence or metastases with an average follow-up of 18 
      months (range 13-23). All tumors had morphologic and immunohistochemical features 
      of mucoepidermoid carcinoma and overexpressed EGFR. MAML2 FISH was negative for 
      MAML2 rearrangement in all tumors. EGFR FISH demonstrated EGFR amplification in 1 
      tumor. CONCLUSIONS: Mucoepidermoid carcinoma of the lacrimal sac is not a 
      lacrimal sac counterpart of CRTC1/3-MAML2 gene fusion-related salivary gland 
      mucoepidermoid carcinoma. EGFR pathway activation and EGFR amplification in a 
      subset of these neoplasms suggest the potential role for anti-EGFR agents.
CI  - Copyright (c) 2019 by S. Karger AG, Basel.
FAU - Gervasio, Kalla A
AU  - Gervasio KA
AD  - Department of Ophthalmology, Wills Eye Hospital, Sidney Kimmel Medical College of 
      Thomas Jefferson University, Philadelphia, Pennsylvania, USA.
FAU - Zhang, Paul J L
AU  - Zhang PJL
AD  - Department of Pathology and Laboratory Medicine, Hospital of The University of 
      Pennsylvania, Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
FAU - Penne, Robert B
AU  - Penne RB
AD  - Department of Ophthalmology, Wills Eye Hospital, Sidney Kimmel Medical College of 
      Thomas Jefferson University, Philadelphia, Pennsylvania, USA.
AD  - Oculoplastic and Orbital Surgery Service, Wills Eye Hospital, Sidney Kimmel 
      Medical College of Thomas Jefferson University, Philadelphia, Pennsylvania, USA.
FAU - Stefanyszyn, Mary A
AU  - Stefanyszyn MA
AD  - Department of Ophthalmology, Wills Eye Hospital, Sidney Kimmel Medical College of 
      Thomas Jefferson University, Philadelphia, Pennsylvania, USA.
AD  - Oculoplastic and Orbital Surgery Service, Wills Eye Hospital, Sidney Kimmel 
      Medical College of Thomas Jefferson University, Philadelphia, Pennsylvania, USA.
FAU - Eagle, Ralph C Jr
AU  - Eagle RC Jr
AD  - Department of Ophthalmology, Wills Eye Hospital, Sidney Kimmel Medical College of 
      Thomas Jefferson University, Philadelphia, Pennsylvania, USA.
AD  - Department of Pathology, Wills Eye Hospital, Sidney Kimmel Medical College of 
      Thomas Jefferson University, Philadelphia, Pennsylvania, USA.
FAU - Puthiyaveettil, Raghunath
AU  - Puthiyaveettil R
AD  - Department of Pathology and Laboratory Medicine, Hospital of The University of 
      Pennsylvania, Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
FAU - Milman, Tatyana
AU  - Milman T
AD  - Department of Ophthalmology, Wills Eye Hospital, Sidney Kimmel Medical College of 
      Thomas Jefferson University, Philadelphia, Pennsylvania, USA.
AD  - Department of Pathology, Wills Eye Hospital, Sidney Kimmel Medical College of 
      Thomas Jefferson University, Philadelphia, Pennsylvania, USA.
LA  - eng
PT  - Journal Article
DEP - 20190920
PL  - Switzerland
TA  - Ocul Oncol Pathol
JT  - Ocular oncology and pathology
JID - 101656139
PMC - PMC7109434
OTO - NOTNLM
OT  - Adenosquamous carcinoma
OT  - CRTC1/3-MAML2
OT  - EGFR
OT  - Lacrimal sac carcinoma
OT  - Lacrimal sac mucoepidermoid carcinoma
OT  - MAML2
OT  - Mucoepidermoid carcinoma
COIS- The authors have no conflicts of interest to declare. None of the authors have 
      relevant financial relationships with commercial interests.
EDAT- 2020/04/08 06:00
MHDA- 2020/04/08 06:01
PMCR- 2021/03/01
CRDT- 2020/04/08 06:00
PHST- 2019/07/03 00:00 [received]
PHST- 2019/08/12 00:00 [accepted]
PHST- 2020/04/08 06:00 [entrez]
PHST- 2020/04/08 06:00 [pubmed]
PHST- 2020/04/08 06:01 [medline]
PHST- 2021/03/01 00:00 [pmc-release]
AID - oop-0006-0138 [pii]
AID - 10.1159/000502699 [doi]
PST - ppublish
SO  - Ocul Oncol Pathol. 2020 Mar;6(2):138-144. doi: 10.1159/000502699. Epub 2019 Sep 
      20.