PMID- 32258113
OWN - NLM
STAT- MEDLINE
DCOM- 20201217
LR  - 20220413
IS  - 2314-6141 (Electronic)
IS  - 2314-6133 (Print)
VI  - 2020
DP  - 2020
TI  - Isoflurane Postconditioning Upregulates Phosphorylated Connexin 43 in the Middle 
      Cerebral Artery Occlusion Model and Is Probably Associated with the 
      TGF-beta1/Smad2/3 Signaling Pathway.
PG  - 3451215
LID - 10.1155/2020/3451215 [doi]
LID - 3451215
AB  - AIM: Connexin 43 (Cx43) has been identified to be important for cerebral 
      ischemia/reperfusion (I/R) injury as well as protection from it. This study was 
      aimed at investigating the relationship between phosphorylated Cx43 (p-Cx43), 
      transforming growth factor-beta1 (TGF-beta1 (TGF. METHODS: The middle cerebral artery 
      occlusion (MCAO) model was induced in 96 male Sprague-Dawley rats, weighing 
      250-300 g. The rats were randomized into 12 groups, namely, sham, middle cerebral 
      artery occlusion (MCAO)/I/R, I/R+1.5% ISPOC, I/R+LY2157299 (blocker of TGF-beta1 
      (TGF-beta1 (TGF-beta1 (TGF-beta1 (TGF. RESULTS: Neurological deficit scores, brain infarct 
      volume, and damaged neurons in the I/R group significantly increased compared to 
      those in the sham group (P < 0.05). However, in the ISPOC group, damage of the 
      brain was significantly ameliorated (P < 0.05). However, in the ISPOC group, 
      damage of the brain was significantly ameliorated (P < 0.05). However, in the 
      ISPOC group, damage of the brain was significantly ameliorated (beta1 (TGF-P < 
      0.05). However, in the ISPOC group, damage of the brain was significantly 
      ameliorated (beta1 (TGF-P < 0.05). However, in the ISPOC group, damage of the brain 
      was significantly ameliorated (beta1 (TGF-beta1 (TGF-P < 0.05). However, in the ISPOC 
      group, damage of the brain was significantly ameliorated (. CONCLUSION: 
      Isoflurane postconditioning (ISPOC) may alleviate cerebral I/R injury through 
      upregulating the expression of p-Cx43, and the TGF-beta1/Smad2/3 signaling pathway 
      may be involved in the process.beta1 (TGF.
CI  - Copyright (c) 2020 Jiangwen Yin et al.
FAU - Yin, Jiangwen
AU  - Yin J
AUID- ORCID: 0000-0002-7260-6277
AD  - Department of Anesthesiology, First Affiliated Hospital, School of Medicine, 
      Shihezi University, Shihezi 832002, China.
FAU - Liu, Xuejiao
AU  - Liu X
AD  - Department of Anesthesiology, The First Affiliated Hospital of Wenzhou Medical 
      University, Wenzhou 325000, China.
FAU - Wang, Ruixue
AU  - Wang R
AD  - Department of Anesthesiology, First Affiliated Hospital, School of Medicine, 
      Shihezi University, Shihezi 832002, China.
FAU - Ge, Mingyue
AU  - Ge M
AD  - Department of Anesthesiology, First Affiliated Hospital, School of Medicine, 
      Shihezi University, Shihezi 832002, China.
FAU - Xie, Liping
AU  - Xie L
AD  - Department of Anesthesiology, First Affiliated Hospital, School of Medicine, 
      Shihezi University, Shihezi 832002, China.
FAU - Zhai, Jingwen
AU  - Zhai J
AD  - Department of Anesthesiology, First Affiliated Hospital, School of Medicine, 
      Shihezi University, Shihezi 832002, China.
FAU - Dai, Zhigang
AU  - Dai Z
AD  - Department of Anesthesiology, First Affiliated Hospital, School of Medicine, 
      Shihezi University, Shihezi 832002, China.
FAU - Li, Yan
AU  - Li Y
AUID- ORCID: 0000-0002-7262-2154
AD  - Department of Anesthesiology, First Affiliated Hospital, School of Medicine, 
      Shihezi University, Shihezi 832002, China.
FAU - Wang, Sheng
AU  - Wang S
AUID- ORCID: 0000-0002-1187-3240
AD  - Department of Anesthesiology, First Affiliated Hospital of USTC, Division of Life 
      Sciences and Medicine, University of Science and Technology of China, Hefei, 
      Anhui 230001, China.
LA  - eng
PT  - Journal Article
DEP - 20200317
PL  - United States
TA  - Biomed Res Int
JT  - BioMed research international
JID - 101600173
RN  - 0 (Connexin 43)
RN  - 0 (Pyrazoles)
RN  - 0 (Quinolines)
RN  - 0 (Smad2 Protein)
RN  - 0 (Smad3 Protein)
RN  - 0 (TGFB1 protein, human)
RN  - 0 (Transforming Growth Factor beta1)
RN  - 700874-72-2 (LY-2157299)
RN  - CYS9AKD70P (Isoflurane)
SB  - IM
MH  - Animals
MH  - Brain/diagnostic imaging/drug effects/pathology
MH  - Brain Ischemia/*drug therapy/genetics/pathology
MH  - Connexin 43/*genetics
MH  - Disease Models, Animal
MH  - Humans
MH  - Infarction, Middle Cerebral Artery/drug therapy/genetics/pathology
MH  - Ischemic Postconditioning/methods
MH  - Isoflurane/*pharmacology
MH  - Neurons/drug effects/pathology
MH  - Phosphorylation/genetics
MH  - Pyrazoles/pharmacology
MH  - Quinolines/pharmacology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Reperfusion Injury/*drug therapy/genetics/pathology
MH  - Signal Transduction/drug effects
MH  - Smad2 Protein/genetics
MH  - Smad3 Protein/genetics
MH  - Transforming Growth Factor beta1/*antagonists & inhibitors/genetics
PMC - PMC7103038
COIS- The authors have declared that no competing interests exist.
EDAT- 2020/04/08 06:00
MHDA- 2020/12/18 06:00
PMCR- 2020/03/17
CRDT- 2020/04/08 06:00
PHST- 2019/12/05 00:00 [received]
PHST- 2020/02/20 00:00 [revised]
PHST- 2020/03/04 00:00 [accepted]
PHST- 2020/04/08 06:00 [entrez]
PHST- 2020/04/08 06:00 [pubmed]
PHST- 2020/12/18 06:00 [medline]
PHST- 2020/03/17 00:00 [pmc-release]
AID - 10.1155/2020/3451215 [doi]
PST - epublish
SO  - Biomed Res Int. 2020 Mar 17;2020:3451215. doi: 10.1155/2020/3451215. eCollection 
      2020.