PMID- 32258151 OWN - NLM STAT- MEDLINE DCOM- 20201216 LR - 20220413 IS - 2314-6141 (Electronic) IS - 2314-6133 (Print) VI - 2020 DP - 2020 TI - Multicenter Study of Tetanus Patients in Fujian Province of China: A Retrospective Review of 95 Cases. PG - 8508547 LID - 10.1155/2020/8508547 [doi] LID - 8508547 AB - BACKGROUND: Tetanus is a life-threatening disease in developing countries and is accompanied by a high mortality rate. Although China is the world's largest developing country, there have been few clinical studies on tetanus in China. The purpose of this study was to investigate the epidemiology, incidence, and management of tetanus in Fujian Province and to understand the current treatment and prognosis of tetanus patients. METHODS: This was a retrospective, multicenter observational study of patients who presented with a clinical diagnosis of tetanus at 5 general hospitals in Fujian from January 2008 to December 2018. Data were analyzed using a computer software system. RESULTS: A total of 95 patients were recruited, including 6 newborns. The average age of the adult tetanus patients was 55.53 +/- 15.39 years old. None of the patients knew their previous history of tetanus immunization. The rate of having received human tetanus immunoglobulin (HTIG) was 9.47%. A total of 73 (76.84%) patients were cured, 17 (17.89%) patients had an unknown prognosis, and 5 (5.26%) patients died. Age, severity of illness, and complications all increased the total duration of hospitalization. Compared with endotracheal intubation, tracheotomy increased the length of stay in the ICU (Intensive Care Unit) but did not affect the total hospital length of stay for mechanical ventilation. CONCLUSIONS: With the promotion of nationwide immunization against tetanus and the development of critical care medicine, morbidity and mortality rates of tetanus in Fujian are low. It is important to increase awareness among local physicians and staff in charge of tetanus immunization programs and with regard to neonatal tetanus and drug-induced tetanus. The prevention and treatment of tetanus in developing countries should arouse widespread concern in society. CI - Copyright (c) 2020 Xiaojing Wang et al. FAU - Wang, Xiaojing AU - Wang X AUID- ORCID: 0000-0002-6952-0253 AD - Department of Critical Care Medicine, Fujian Provincial Hospital, Fujian Provincial Center for Critical Care Medicine, Fujian Medical University, Fuzhou, Fujian 350001, China. FAU - Yu, Rongguo AU - Yu R AUID- ORCID: 0000-0002-1648-6821 AD - Department of Critical Care Medicine, Fujian Provincial Hospital, Fujian Provincial Center for Critical Care Medicine, Fujian Medical University, Fuzhou, Fujian 350001, China. FAU - Shang, Xiuling AU - Shang X AUID- ORCID: 0000-0002-5390-6733 AD - Department of Critical Care Medicine, Fujian Provincial Hospital, Fujian Provincial Center for Critical Care Medicine, Fujian Medical University, Fuzhou, Fujian 350001, China. FAU - Li, Jun AU - Li J AD - Department of Critical Care Medicine, Fujian Provincial Hospital, Fujian Provincial Center for Critical Care Medicine, Fujian Medical University, Fuzhou, Fujian 350001, China. FAU - Gu, Ling AU - Gu L AD - Department of Critical Care Medicine, Mindong Hospital of Ningde City, Ningde, Fujian 355000, China. FAU - Rao, Richun AU - Rao R AD - Department of Infectious Diseases, Chaoyang District of Affiliated Zhangzhou Municipal Hospital of Fujian Medical University, Zhangzhou, Fujian 363000, China. FAU - Han, Xianliang AU - Han X AD - Department of Infectious Diseases, Chaoyang District of Affiliated Zhangzhou Municipal Hospital of Fujian Medical University, Zhangzhou, Fujian 363000, China. FAU - Chen, Mingzhi AU - Chen M AD - Department of Infectious Diseases, Chaoyang District of Affiliated Zhangzhou Municipal Hospital of Fujian Medical University, Zhangzhou, Fujian 363000, China. AD - Department of Critical Care Medicine, Jinjiang Municipal Hospital, Jinjiang, Fujian 362200, China. FAU - Yang, Jian AU - Yang J AD - Department of Critical Care Medicine, Affiliated Nanping First Hospital of Fujian Medical University, Nanping, Fujian 353000, China. FAU - Wu, Jiafang AU - Wu J AD - Department of Critical Care Medicine, Fujian Provincial Hospital, Fujian Provincial Center for Critical Care Medicine, Fujian Medical University, Fuzhou, Fujian 350001, China. FAU - Chen, Huilong AU - Chen H AD - Department of Critical Care Medicine, Fujian Provincial Hospital, Fujian Provincial Center for Critical Care Medicine, Fujian Medical University, Fuzhou, Fujian 350001, China. FAU - Huang, Hongyu AU - Huang H AD - Department of Critical Care Medicine, Fujian Provincial Hospital, Fujian Provincial Center for Critical Care Medicine, Fujian Medical University, Fuzhou, Fujian 350001, China. LA - eng PT - Clinical Trial PT - Comparative Study PT - Journal Article PT - Multicenter Study PT - Observational Study DEP - 20200315 PL - United States TA - Biomed Res Int JT - BioMed research international JID - 101600173 SB - IM MH - Adult MH - Aged MH - China/epidemiology MH - Female MH - *Hospitalization MH - Humans MH - Incidence MH - Infant, Newborn MH - Male MH - Middle Aged MH - Retrospective Studies MH - Tetanus/*mortality/*therapy PMC - PMC7103028 COIS- The authors declare that they have no conflicts of interest. EDAT- 2020/04/08 06:00 MHDA- 2020/12/17 06:00 PMCR- 2020/03/15 CRDT- 2020/04/08 06:00 PHST- 2019/12/15 00:00 [received] PHST- 2020/03/05 00:00 [accepted] PHST- 2020/04/08 06:00 [entrez] PHST- 2020/04/08 06:00 [pubmed] PHST- 2020/12/17 06:00 [medline] PHST- 2020/03/15 00:00 [pmc-release] AID - 10.1155/2020/8508547 [doi] PST - epublish SO - Biomed Res Int. 2020 Mar 15;2020:8508547. doi: 10.1155/2020/8508547. eCollection 2020.