PMID- 32259041
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200928
IS  - 2536-4553 (Electronic)
IS  - 2148-4902 (Print)
IS  - 2536-4553 (Linking)
VI  - 7
IP  - 2
DP  - 2020
TI  - Relationship between local and systemic inflammatory response and prognosis in 
      laryngeal squamous cell carcinoma.
PG  - 180-184
LID - 10.14744/nci.2019.02328 [doi]
AB  - OBJECTIVE: Laryngeal squamous cell carcinoma (LSCC) is the most frequently seen 
      head and neck malignancy. Despite improvements in the treatment modalities within 
      the last 20 years, the desired improvement in survival outcomes has not been 
      achieved yet which led researchers to investigate factors that might affect 
      prognosis in LSCCs. METHODS: A total of 116 previously operated patients were 
      included in this study. To assess systemic inflammation, neutrophil/lymphocyte 
      ratio (NLR) and platelet/lymphocyte ratio (PLR) were calculated. The cut-off 
      values for NLR and PLR were accepted as 2.79 and 112, respectively. To evaluate 
      intratumoral inflammation, hematoxylin-eosin stained tumor sections were 
      evaluated. Tumor-infiltrating lymphocyte (TIL) densities in the tumor area were 
      scored as 1+, 2+ and 3+. RESULTS: The mean overall survival was 29.5+/-17.7 months. 
      In univariate analysis, a statistically significant correlation was seen between 
      age group of 60 years, tumor stage, site and OS (p=0.025, p=0.026, p=0.029). 
      There was no statistically significant relationship between PLR, NLR and TIL 
      density and OS. In the multivariate analysis, the 60-year-old group and tumour 
      stage were still significantly associated with the OS (p=0.033, p=0.046). 
      CONCLUSION: Age and tumor stage were significantly associated with survival in 
      our study, but contrary to the literature, no correlation was found between local 
      and systemic inflammatory response.
CI  - Copyright: (c) 2020 by Istanbul Northern Anatolian Association of Public Hospitals.
FAU - Kucuk, Ulku
AU  - Kucuk U
AD  - Department of Pathology, Tepecik Training and Research Hospital, Izmir, Turkey.
FAU - Ekmekci, Sumeyye
AU  - Ekmekci S
AD  - Department of Pathology, Tepecik Training and Research Hospital, Izmir, Turkey.
FAU - Bozkurt, Pinar
AU  - Bozkurt P
AD  - Department of Pathology, Tepecik Training and Research Hospital, Izmir, Turkey.
FAU - Bulgurcu, Suphi
AU  - Bulgurcu S
AD  - Department of Otorhinolaryngology, Sultan Abdulhamid Han Training and Research 
      Hospital, Istanbul, Turkey.
FAU - Cukurova, Ibrahim
AU  - Cukurova I
AD  - Department of Otorhinolaryngology, Tepecik Training and Research Hospital, 
      Istanbul, Turkey.
LA  - eng
PT  - Journal Article
DEP - 20191203
PL  - Turkey
TA  - North Clin Istanb
JT  - Northern clinics of Istanbul
JID - 101684520
PMC - PMC7117628
OTO - NOTNLM
OT  - Inflammation
OT  - laryngeal carcinoma
OT  - prognosis
COIS- Conflict of Interest: No conflict of interest was declared by the authors.
EDAT- 2020/04/08 06:00
MHDA- 2020/04/08 06:01
PMCR- 2019/12/03
CRDT- 2020/04/08 06:00
PHST- 2019/03/21 00:00 [received]
PHST- 2019/11/09 00:00 [accepted]
PHST- 2020/04/08 06:00 [entrez]
PHST- 2020/04/08 06:00 [pubmed]
PHST- 2020/04/08 06:01 [medline]
PHST- 2019/12/03 00:00 [pmc-release]
AID - NCI-7-180 [pii]
AID - 10.14744/nci.2019.02328 [doi]
PST - epublish
SO  - North Clin Istanb. 2019 Dec 3;7(2):180-184. doi: 10.14744/nci.2019.02328. 
      eCollection 2020.