PMID- 32259433
OWN - NLM
STAT- MEDLINE
DCOM- 20210702
LR  - 20240329
IS  - 1520-5010 (Electronic)
IS  - 0893-228X (Print)
IS  - 0893-228X (Linking)
VI  - 33
IP  - 4
DP  - 2020 Apr 20
TI  - The Ah Receptor: Adaptive Metabolism, Ligand Diversity, and the Xenokine Model.
PG  - 860-879
LID - 10.1021/acs.chemrestox.9b00476 [doi]
AB  - The Ah receptor (AHR) has been studied for almost five decades. Yet, we still 
      have many important questions about its role in normal physiology and 
      development. Moreover, we still do not fully understand how this protein mediates 
      the adverse effects of a variety of environmental pollutants, such as the 
      polycyclic aromatic hydrocarbons (PAHs), the chlorinated dibenzo-p-dioxins 
      ("dioxins"), and many polyhalogenated biphenyls. To provide a platform for future 
      research, we provide the historical underpinnings of our current state of 
      knowledge about AHR signal transduction, identify a few areas of needed research, 
      and then develop concepts such as adaptive metabolism, ligand structural 
      diversity, and the importance of proligands in receptor activation. We finish 
      with a discussion of the cognate physiological role of the AHR, our perspective 
      on why this receptor is so highly conserved, and how we might think about its 
      cognate ligands in the future.
FAU - Avilla, Mele N
AU  - Avilla MN
FAU - Malecki, Kristen M C
AU  - Malecki KMC
FAU - Hahn, Mark E
AU  - Hahn ME
AUID- ORCID: 0000-0003-4358-2082
AD  - Biology Department, Woods Hole Oceanographic Institution, Woods Hole, 
      Massachusetts 02543-1050, United States.
FAU - Wilson, Rachel H
AU  - Wilson RH
FAU - Bradfield, Christopher A
AU  - Bradfield CA
AD  - McArdle Laboratory for Cancer Research, University of Wisconsin School of 
      Medicine and Public Health, Madison, Wisconsin 53705-227, United States.
LA  - eng
GR  - P30 CA014520/CA/NCI NIH HHS/United States
GR  - P42 ES007381/ES/NIEHS NIH HHS/United States
GR  - R35 ES028377/ES/NIEHS NIH HHS/United States
GR  - T32 ES007015/ES/NIEHS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20200407
PL  - United States
TA  - Chem Res Toxicol
JT  - Chemical research in toxicology
JID - 8807448
RN  - 0 (Environmental Pollutants)
RN  - 0 (Ligands)
RN  - 0 (Polychlorinated Dibenzodioxins)
RN  - 0 (Polycyclic Aromatic Hydrocarbons)
RN  - 0 (Receptors, Aryl Hydrocarbon)
SB  - IM
MH  - Animals
MH  - Environmental Pollutants/chemistry/*pharmacology
MH  - Humans
MH  - Ligands
MH  - Molecular Structure
MH  - Polychlorinated Dibenzodioxins/chemistry/*pharmacology
MH  - Polycyclic Aromatic Hydrocarbons/chemistry/*pharmacology
MH  - Receptors, Aryl Hydrocarbon/genetics/*metabolism
MH  - Signal Transduction/drug effects
PMC - PMC7175458
COIS- The authors declare no competing financial interest.
EDAT- 2020/04/08 06:00
MHDA- 2021/07/03 06:00
PMCR- 2020/04/22
CRDT- 2020/04/08 06:00
PHST- 2020/04/08 06:00 [pubmed]
PHST- 2021/07/03 06:00 [medline]
PHST- 2020/04/08 06:00 [entrez]
PHST- 2020/04/22 00:00 [pmc-release]
AID - 10.1021/acs.chemrestox.9b00476 [doi]
PST - ppublish
SO  - Chem Res Toxicol. 2020 Apr 20;33(4):860-879. doi: 10.1021/acs.chemrestox.9b00476. 
      Epub 2020 Apr 7.